Charge-transfer Complexes Formed between the Sweeteners Saccharin Drug and Acido Acceptors: Structural, Thermal and Morphological Features

Abstract

Saccharin (sacH) is a sugar substitute sweetening agent used extensively in dietary products. It is about 300 times sweeter than sucrose. This study highlighted the structural chemistry of Charge Transfer (CT) complexes formed from the interactions of two acido acceptors (CLA and PA) with sacH. The IR and 1 H NMR revealed evidence of significant intermolecular interactions between N-H group in the sacH and O-H group in the acido acceptors based on their characteristic shifts. The TG and DTA experiments were carried out to investigate the thermal properties of the obtained complexes. Their morphological features were also investigated using Optical Light Microscope (OLM). The OLM micrograph patterns indicate the formation of high quality colored crystals. This study provided the essential basics for understanding the complexation chemistry of saccharin.

Study of Charge transfer complexes of chlorothiazide

“…(Salama et al, 2011). The CT-complexes were given from the reactions of chloranlic acid and picric acid with the Sweeteners Saccharin (Naglah et al, 2015). Interaction of 3, 5dimethylpyrazole with 2, 3-dichloro-5, 6-dicyano-p-benzoquinon were studied (Habeeb et al, 2015).…”