Charge-Transfer Reaction of Chloranilic Acid with Crizotinib: Spectrophotometric Study, Computational Modeling and Use in Development of Microwell Assay for Crizotinib

Charge-Transfer Complex of Linifanib with 2,3-dichloro-3,5-dicyano-1,4-benzoquinone: Synthesis, Spectroscopic Characterization, Computational Molecular Modelling and Application in the Development of Novel 96-microwell Spectrophotometric Assay

“…[4][5][6][7][8][9] The formation of CT complexes was also used as the basis for development of simple, rapid, and reliable methods for the qualitative detection and quantitative determination of drugs in bulk and/or pharmaceutical dosage forms. [10][11][12][13][14][15][16][17][18][19] The properties and characteristics of the CT complexes such as their crystallographic properties, thermal stabilities, and effects of solvents, reagent concentration, temperature, and other parameters have also been intensively described and discussed. [20][21][22][23][24][25] Over the past years, we have been involved in studying the formation and applications of CT complexes of several drugs, such as macrolide antibiotics, cephalosporines, crizotinib, olmesartan medoxamil, losartan potassium, cediranib, rosuvastatin calcium, and atorvastatin calcium with different acceptors.…”

“…[20][21][22][23][24][25] Over the past years, we have been involved in studying the formation and applications of CT complexes of several drugs, such as macrolide antibiotics, cephalosporines, crizotinib, olmesartan medoxamil, losartan potassium, cediranib, rosuvastatin calcium, and atorvastatin calcium with different acceptors. [10][11][12][13][14][15][16][17][18][19] The aim of our studies was to understand the chemistry behind the CT complexation of these drugs and to learn more about their electron donation behaviors toward several electron acceptors.…”

Synthesis, spectroscopic and computational characterization of charge transfer complex of remdesivir with chloranilic acid: Application to development of novel 96-microwell spectrophotometric assay

“…CTC creation is also crucial in a multitude of fields, including the production of optical and electrically conductive materials [10] , [11] , [12] , [13] , microemulsions and surface chemistry [14] , photocatalysis [15] , dendrimers [16] , solar energy storage [17] , and organic semiconductors [18] . Additionally, the generation of CTC between drugs and specific σ- and π-acceptors has been effectively employed as the basis for designing high-accuracy assays for both qualitative and quantitative detection of pharmaceuticals in bulk and/or pharmaceutical dose forms [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] .…”

“…We've been evaluating the development and applications of CTC in a variety of pharmaceuticals with diverse acceptors over the past few years. Antibiotics, kinase inhibitors, antihypertensives and antihyperlipidemics were among the pharmaceuticals used [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] . Our research focused on understanding the chemistry of these pharmaceuticals' CT reactions and their electron donating manners toward a variety of electron acceptors.…”

Enhanced spectrofluorimetric determination of the multitargeted tyrosine kinase inhibitor, crizotinib, in human plasma via micelle-mediated approach

“…However, these chromatographic methods suffered from complexity and being expensive. Few spectrophotometric methods have been reported for determination of CRZ in dosage form [11][12][13]. Thus development of simple and sensitive analytical methodology for CRZ determination in plasma is demanded.…”