Charge variable PIB-based block copolymers as selective transmembrane ion transporters

Dey, Asmita Deka; Haldar, Ujjal; Rajasekhar, Tota; Faust, Rudolf; De, Priyadarsi

doi:10.1039/d3py00274h

Cited by 3 publications

(4 citation statements)

References 43 publications

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“…For the halides, the ion transport trend follows the Hofmeister series, that is, I À > Br À > Cl À , while in the case of oxygenated anions NO 2 À is better transported with respect to ClO 4 À , despite its higher hydration energy, suggesting some possible specific interaction with the polymer. 48,49 This suggests that the higher dehydration energy along with the size of the anions plays crucial roles in the transport behavior. Overall independence of the transport rate from the nature of the cation and dependence from the nature of the anion indicates that the copolymers form anion selective pore.…”

Section: Resultsmentioning

confidence: 99%

Anion‐selective macromolecular artificial ionophores with steroid and fatty acid pendants

Sahoo

Dey

Tecilla

et al. 2023

Journal of Polymer Science

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Synthetic anion transporters are potential therapeutics for a plethora of cellular ailments including cystic fibrosis, cancer resistance, epilepsy, etc. In this context, cationic macromolecular amphiphiles are gaining revived interest because of their easy synthesis and ample ion channelization through the membrane barrier. Herein, side chain alanine containing cationic polymer amphiphiles with steroid/fatty acid decoration was established to be an efficient anion‐selective artificial ionophore. The facile amphiphilicity‐assisted assembly makeover of cholic acid containing copolymers channelized the better transmembrane anion transport and efficiency with the maximum selectivity found with NO2− ion.

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Section: Resultsmentioning

confidence: 99%

Anion‐selective macromolecular artificial ionophores with steroid and fatty acid pendants

Sahoo

Dey

Tecilla

et al. 2023

Journal of Polymer Science

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“…In particular, block polymers, which are composed of two or more segments with distinct monomer compositions and complex arrangements, hold significance in the progress of developing new technologies. 76,77 Depending on the monomer selection, length of individual blocks, and number of polymer blocks, multiblock copolymers can exhibit a range of unique characteristics. 78,79 The homopolymers of acrylates provide adhesion and chemical resistance, 80 whereas, poly(vinyl ether)s have flexibility, impact resistance, and low-temperature performance.…”

Section: Combination Of Cationic Polymerization With Other Polymeriza...mentioning

confidence: 99%

“…By this method, the desired properties of different monomers can be combined into a single polymer. In particular, block polymers, which are composed of two or more segments with distinct monomer compositions and complex arrangements, hold significance in the progress of developing new technologies. , Depending on the monomer selection, length of individual blocks, and number of polymer blocks, multiblock copolymers can exhibit a range of unique characteristics. , …”

Section: Introductionmentioning

confidence: 99%

Recent Developments on Cationic Polymerization of Vinyl Ethers

Singha,

Pan,

Tallury

et al. 2024

ACS Polym. Au

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In recent times, the evolution of cationic polymerization has taken a multidirectional approach, with the development of cationic reversible addition−fragmentation chain transfer (RAFT) polymerization. In contrast to the conventional cationic polymerization methods, which were typically carried out under inert atmospheres and low temperatures, various novel polymerization techniques have been developed where the reactions are carried out in open air, operate at room temperature, are cost-effective, and are environmentally friendly. Besides, several external stimuli, such as heat, light, chemicals, electrical potential, etc. have been employed to activate and control the polymerization process. It also enables the combination of cationic polymerization with other polymerization methods in a single reaction vessel, eliminating the necessity for isolation and purification during intermediate steps. In addition, significant advancements have been made through various modifications in catalyst systems, resulting in polymers with an exceptionally high level of stereoregularity. This review article comprehensively analyses the recent developments in cationic polymerization, encompassing their applications and offering insights into future perspectives.

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“…Its deprotection resulted in an amphiphilic copolymer with free –NH 3 + and –COO − functionalities in an alternating fashion that demonstrated pH-responsive self-assembly [ 172 ]. A similar approach was used in the synthesis of PIB block copolymers containing aninonic (acrylic acid monomer), neutral (MeO(CH 2 CH 2 O) 4 -actylate monomer) and cationic ((Boc)-leucine-OCH 2 CH 2 O-acrylate monomer) fragments, designed for ion transport through the liposomal membrane [ 173 ]. RAFT copolymerization was also used for the synthesis of PIB-containing copolymer with glucose-decorated hydrophilic segment that showed high efficiency in the protection of the insulin aggregation [ 174 ].…”

Section: Further Transformations Of Hrpib (Pib-cl) and Applications O...mentioning

confidence: 99%

Polyisobutylenes with Controlled Molecular Weight and Chain-End Structure: Synthesis and Actual Applications

et al. 2023

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The polymerization of isobutylene allows us to obtain a wide spectrum of polyisobutylenes (PIBs) which differ in their molecular weight characteristics and the chemical structure of chain-end groups. The bulk of the PIBs manufactured worldwide are highly reactive polyisobutylenes (HRPIBs) with –C(Me)=CH2 end-groups and low-molecular weights (Mn < 5 kDa). HRPIBs are feedstocks that are in high demand in the manufacturing of additives for fuels and oils, adhesives, detergents, and other fine chemicals. In addition, HRPIBs and CMe2Cl-terminated PIBs are intensively studied with the aim of finding biomedical applications and for the purpose of developing new materials. Both chain control (molecular weight and dispersity) and chemoselectivity (formation of exo-olefinic or –CMe2Cl groups) should be achieved during polymerization. This review highlights the fundamental issues in the mechanisms of isobutylene polymerization and PIB analysis, examines actual catalytic approaches to PIBs, and describes recent studies on the functionalization and applications of HRPIBs and halogen-terminated PIBs.

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Charge variable PIB-based block copolymers as selective transmembrane ion transporters

Abstract: Artificial functional ionophores are essential for selective transmembrane ion transport since ion transport through biological membranes is an essential phenomenon and its disruption causes a variety of illnesses. Herein, we...

Cited by 3 publications

References 43 publications

Anion‐selective macromolecular artificial ionophores with steroid and fatty acid pendants

Anion‐selective macromolecular artificial ionophores with steroid and fatty acid pendants

Recent Developments on Cationic Polymerization of Vinyl Ethers

Polyisobutylenes with Controlled Molecular Weight and Chain-End Structure: Synthesis and Actual Applications

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