Charged Gold Nanoparticles in Non-Polar Solvents: 10-min Synthesis and 2D Self-Assembly

Martin, Matthew N.; Basham, James I.; Chando, Paul; Eah, Sang-Kee

doi:10.1021/la100591h

Cited by 304 publications

(276 citation statements)

References 54 publications

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“…In the case of sodium citrate reduction, the citrate acts as a loosely bound capping agent stabilizing the particles. Tetradecane, octadecane or dodecane thiols are often used as capping agents to stabilize AuNPs produced via sodium borohydride reduction [19,20]. The biological response can be altered using capping agents such as polyethylene glycol (PEG) also referred to as polyethylene oxide (PEO) [20,21], mercaptosuccinic acid, various proteins [21] or other biomolecules [2].…”

Section: Introductionmentioning

confidence: 99%

Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media

et al. 2011

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Thiol-terminated polyethylene glycol (PEG) is commonly used to functionalize the surface of gold nanoparticles (AuNPs) in order to improve their in vivo stability and to avoid uptake by the reticular endothelial system. Although it has been reported that AuNPs functionalized with tethered PEG are stable in biological media, the influence of chain density remains unclear. This study investigates the influence of PEG capping density on the stability of washed and dried AuNPs in: water, phosphate-buffered saline solution (PBS), phosphate-buffered saline solution containing bovine serum albumin (PBS/BSA), and dichloromethane (DCM). PEG coating had a dramatic effect on stability enabling stable suspensions to be produced in all the media studied. A linear relationship was observed between capping density and stability in water and DCM with a somewhat lower stability observed in PBS and PBS/BSA. A maximum PEG loading level of ∼14 wt.% was achieved, equivalent to a PEG surface density of ∼1.13 chains/nm 2 .

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Section: Introductionmentioning

confidence: 99%

Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media

et al. 2011

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“…5 nm Au nanoparticles were prepared following previously described methods. 50 Briefly, 1ml of 50 mM AuCl 4 solution was added to 93.5 ml ultrapure water, and 6.5 ml of NaBH 4 solution (prepared by mixing 18.5 mg NaBH 4 in 9.5 ml water and 0.5 ml 1M NaOH). After 5 minutes mixing at room temperature, the temperature was increased to 100 o C for 5 minutes.…”

Section: Nanoparticle Synthesismentioning

confidence: 99%

Nanoparticle accumulation and transcytosis in brain endothelial cell layers

et al. 2013

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The Blood-Brain Barrier (BBB) is a selective barrier, which controls and limits access to the central nervous system (CNS). The selectivity of the BBB relies on specialized characteristics of the endothelial cells that line the microvasculature, including the expression of intercellular tight junctions, which limit paracellular permeability. Several reports suggest that nanoparticles have a unique capacity to cross the BBB. However, direct evidence of nanoparticle transcytosis is difficult to obtain, and we found that typical transport studies present several limitations when applied to nanoparticles. In order to investigate the capacity of nanoparticles to access and transport across the BBB, several different nanomaterials, including silica, titania and albumin-or transferrinconjugated gold nanoparticles of different sizes, were exposed to a human in vitro BBB model of endothelial hCMEC/D3 cells. Extensive transmission electron microscopy imaging was applied in order to describe nanoparticle endocytosis and typical intracellular localisation, as well as to look for evidence of eventual transcytosis. Our results show that all of the nanoparticles were internalised, to different extents, by the BBB model and accumulated along the endo-lysosomal pathway. Rare events suggestive of nanoparticle transcytosis were also observed for several of the tested materials.

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“…The problem of the conservation of the initial size of nanoparticles during the isolation process is a very urgent task, so the isolation of the particles is performed in the presence of a protective agent preventing their agglomeration. Different types of protective reagents for gold nanoparticles are known, in particular citrate ion [6,7], alkylthiols [22][23][24], alkylthioacetates [25], organic amines [26,27], and phosphines [28].…”

Section: Introductionmentioning

confidence: 99%

Di-(2-ethylhexyl) dithiophosphoric acid surface protected gold nanoparticles: micellar synthesis, stabilization, isolation, and properties

et al. 2011

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Gold nanoparticles (AuNPs) were synthesized in the organic solution by means of the reduction of HAuCl 4 by hydrazine in reverse micelles of oxyethylated surfactant Triton N-42, with decane as the dispersion medium. To isolate the powder of particles, the micelles were destroyed with chloroform in the presence of di-(2-ethylhexyl) dithiophosphoric acid as a surface protecting agent. According to the results of several experiments, the yield is within the limits of 90-98%, calculated for gold. The obtained preparations are dark blue hydrophobic powders containing aggregated but not agglomerated gold nanoparticles, as well as microcrystals (∼0.08-0.2 μm) of NaCl. The powders get re-dispersed in weakly polar organic solvents with the formation of colloidal solutions. The shape of the nanoparticles is spherical. Their nuclei are gold single crystals with a narrow size distribution; their diameter (d Au ) is about two times as large as the diameter of the aqueous nucleus (d c ) of initial micelles: d Au =7.7±

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Charged Gold Nanoparticles in Non-Polar Solvents: 10-min Synthesis and 2D Self-Assembly

Cited by 304 publications

References 54 publications

Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media

Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media

Nanoparticle accumulation and transcytosis in brain endothelial cell layers

Di-(2-ethylhexyl) dithiophosphoric acid surface protected gold nanoparticles: micellar synthesis, stabilization, isolation, and properties

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