In this paper, we discuss the generalized Einstein–Maxwell–Dilaton gravity theory with a nonminimal coupling between the Maxwell field and scalar field. Considering different geometric properties of black hole horizon structure, the charged dilaton Lifshitz black hole solutions are presented in 4-dimensional spacetimes. Later, utilizing the Wald Formalism, we derive the thermodynamic first law of black hole and conserved quantities. According to the relationship between the heat capacity and the local stability of black hole, we study the stability of charged Lifshitz black holes and identify the thermodynamic stable region of black holes that meet the criteria.