2007
DOI: 10.1002/macp.200700216
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Charged Polymers via Controlled Radical Polymerization and their Implications for Gene Delivery

Abstract: Non‐viral gene delivery agents are notorious for their poor nucleic acid transfection efficiency and relatively high cell cytotoxicity. Thus, many investigators are exploring the important parameters involved in charged polymer‐mediated gene delivery, such as chemical composition, molecular weight, structural architecture, surface charge, etc. It is important to develop clear structure‐property relationships in order to design successful nucleic acid delivery agents for gene therapy. To elucidate these relatio… Show more

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Cited by 41 publications
(38 citation statements)
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“…[157,158] Different synthetic methods for preparing star polymers containing disulfide linkers, exploiting ''arm first'' or ''core first'' approaches, by RAFT polymerization have been reported. [159,160] The ''arm first approach'' requires the pre-synthesis of linear polymer chains that are subsequently coupled to a functional core or polymerized in the presence of a crosslinker to yield star polymers.…”
Section: Star /Hyperbranched Polymermentioning
confidence: 99%
“…[157,158] Different synthetic methods for preparing star polymers containing disulfide linkers, exploiting ''arm first'' or ''core first'' approaches, by RAFT polymerization have been reported. [159,160] The ''arm first approach'' requires the pre-synthesis of linear polymer chains that are subsequently coupled to a functional core or polymerized in the presence of a crosslinker to yield star polymers.…”
Section: Star /Hyperbranched Polymermentioning
confidence: 99%
“…New techniques for polymerization and novel methods of characterization and analytical tools have been developed to meet the challenge to make polymers with absolutely uniform length with control on polymer stereochemistry and co-polymers with precisely determined sequences and to provide control of both topology and molecular geometry. Novel anionic and cationic polymerizations [54], ring-opening polymerization [55,56], atom-transfer polymerization (ATRP) (see Scheme 1) [57], reversible addition-fragmentation chain-transfer (RAFT) polymerization [58], nitroxyl-radical-mediated polymerization [59,60], 'click' chemistry [61], etc., could be used to make predictable polymer backbone structures. The introduction of novel polymer topologies made from bio-polymers and synthetic polymers, the potential of macromolecules to form supramolecular assemblies with unique properties, the use of supercritical fluids, high-pressure or catalytic processes with specially designed carriers, etc., have contributed immensely for the bio-inspired synthesis of novel synthetic bio-polymers of sophisticated properties [62,63] Polymers with uniform structures are characterized by a narrow molecular weight distribution (MWD).…”
Section: Application Of Modern Methods Of Molecular Design and Procesmentioning
confidence: 99%
“…[9][10][11] Cationic polymers have attracted a lot of research interest as potential non-viral vectors as they have the potential to complex with negative charged DNA or RNA, generating neutral or positive charged polyplexes, with the ability to cross the negative charged cell membrane. [12] There are two main obstacles to the use of cationic polymers, polyplex unpacking, and cytotoxicity. It is known that increase in the positive charge on a polymer improves cellular uptake and transfection efficiency, but the accompanying detrimental toxicity effect originating from the destabilization and loss of integrity of the cell membrane is also enhanced, leading to a narrow operating window between efficiency and severe toxicity.…”
Section: Introductionmentioning
confidence: 99%