We present next-to-next-to-leading order (NNLO) parton distribution functions (PDFs) from the CTEQ-TEA group. The CT10NNLO PDF fit is based on essentially the same global data sets used in the CT10 and CT10W NLO PDF analyses. After exploring the goodness of the fits to the HERA combined data and the Tevatron jet data, we present various predictions at NNLO accuracy for both existing and forthcoming precision measurements from the CERN Large Hadron Collider. The range of variations in the gluon distribution introduced by correlated systematic effects in inclusive jet production is also examined.