2024
DOI: 10.1097/rlu.0000000000005190
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Charting the Course of Targeted α Therapy With First-in-Human, Postadministration Image-Guided Dosimetry and Response Assessment of 212Pb-VMT-α-NET in Metastatic Neuroendocrine Tumors

Navneet Singh,
Nishant Rana,
Parul Thakral
et al.

Abstract: 212Pb emerges as a compelling in vivo α-particle generator for targeted α therapy due to its favorable half-life (t 1/2 = 10.6 hours) aligning with the biological half-lives of small peptides and its potent α-particle emissions within the decay series. However, one of the challenges with 212Pb is to perform appropriate image-guided dosimetry. To date, all the data have been extrapolated from its imaging analog, 203Pb. We present the first-in-human posttherapy image-guided dosimetric … Show more

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