2017
DOI: 10.1002/wdev.289
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Charting the genotype–phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel

Abstract: Understanding the genetic architecture (causal molecular variants, their effects and frequencies) of quantitative traits is important for precision agriculture and medicine and predicting adaptive evolution, but is challenging in most species. The Drosophila melanogaster Genetic Reference Panel (DGRP) is a collection of 205 inbred strains with whole genome sequences derived from a single wild population in Raleigh, North Carolina, USA. The large amount of quantitative genetic variation, lack of population stru… Show more

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Cited by 132 publications
(162 citation statements)
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“…The original DGRP lines were constructed such that population structure effects should be minimized, but some genetic relatedness leading to cryptic population structure might still exist (Mackay & Huang, ). In order to correct any major influence from the cryptic population structure that we identified above, a linear mixed model using the FastLMM (Lippert et al, ) program (version 0.2.32) was applied.…”
Section: Resultsmentioning
confidence: 99%
“…The original DGRP lines were constructed such that population structure effects should be minimized, but some genetic relatedness leading to cryptic population structure might still exist (Mackay & Huang, ). In order to correct any major influence from the cryptic population structure that we identified above, a linear mixed model using the FastLMM (Lippert et al, ) program (version 0.2.32) was applied.…”
Section: Resultsmentioning
confidence: 99%
“…Understanding how naturally occurring genetic variation affects variation in organismal quantitative traits by modifying underlying molecular networks is a key challenge in modern biology. Most traits are highly polygenic 13 and associated molecular variants have small additive effects on trait variation 4 . Most of these variants are in intergenic regions, up- or down- stream of coding regions, or in introns, and presumably play a regulatory role in modulating gene expression.…”
Section: Introductionmentioning
confidence: 99%
“…We define this type of genotype by environment interaction (GEI) as a genotype by early-life nutrition interaction (GENI) [11]. Drosophila provides exceptionally powerful tools and approaches for exploring the mechanisms underlying GENI at the single gene and genome-wide level [12]. The D. melanogaster Genetic Reference Panel (DGRP) [13] consists of sequenced inbred lines derived from a natural population that has been extensively used to chart the genotype-phenotype architecture of complex traits, including behaviors and brain morphology [12].…”
Section: Introductionmentioning
confidence: 99%
“…Drosophila provides exceptionally powerful tools and approaches for exploring the mechanisms underlying GENI at the single gene and genome-wide level [12]. The D. melanogaster Genetic Reference Panel (DGRP) [13] consists of sequenced inbred lines derived from a natural population that has been extensively used to chart the genotype-phenotype architecture of complex traits, including behaviors and brain morphology [12]. DGRP lines reared under different nutritional conditions show changes in behaviors and metabolic and transcriptional profiles, revealing a key role of GENI [14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%