Chaunopycnis pustulata sp. nov., a new clavicipitalean anamorph producing metabolites that modulate potassium ion channels

Bills, Gerald F.; Polishook, Jon D.; Goetz, Michael; Sullivan, Raymond F.; White, James F.

doi:10.1007/s11557-006-0001-3

Cited by 22 publications

(10 citation statements)

References 38 publications

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“…In this work, we identified three clavicipitalean fungi (Beauveria brongniartii, Chaunopycnis sp., and Chaunopycnis alba) and two ustilaginomycetous fungi (Meira argovae and Acaromyces ingoldii), which are rarely detected as endophytes (Paz et al 2007;Tanaka et al 2008;Thomas et al 2008;Giordano et al 2009;Reay et al 2010). Recent work demonstrates that these entomopathogens appear to have a broad spectrum anti-pathogenic activity (Bills et al 2002;Sztejnberg et al 2004;Zimmermann 2007;Gerson et al 2008). These findings prompt the suggestion that the endophytic stage of these fungi, in a tri-trophic context, may play an important role in plant interactions with pests (Elliot et al 2000).…”

Section: The Biodiversityefunctional Relationship In Saprophytic and mentioning

confidence: 83%

From pattern to process: species and functional diversity in fungal endophytes of Abies beshanzuensis

et al. 2011

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Section: The Biodiversityefunctional Relationship In Saprophytic and mentioning

confidence: 83%

From pattern to process: species and functional diversity in fungal endophytes of Abies beshanzuensis

et al. 2011

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“…The other species of Tolypocladium have no known sexual morphs and have mainly been isolated from soil ( Gams 1971 , Bissett 1983 ) or observed parasitizing rotifers or insects ( Barron 1980 , 1981 , 1983 , Samson & Soares 1984 , Weiser et al 1991 ). The asexually typified genus Chaunopycnis is also related to this clade ( Bills et al 2002 ) and has been isolated mainly from soil samples ( Gams 1980 , Bills et al 2002 ), although one species was isolated from epilithic Antarctic lichens ( Möller & Gams 1993 ). The similarity of conidiogenesis between Chaunopycnis and Tolypocladium was noted in the original description of Chaunopycnis ( Gams 1980 ), and its phialides often taper in a manner similar to those of Tolypocladium .…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic-based nomenclatural proposals for Ophiocordycipitaceae (Hypocreales) with new combinations in Tolypocladium

et al. 2014

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Ophiocordycipitaceae is a diverse family comprising ecologically, economically, medicinally, and culturally important fungi. The family was recognized due to the polyphyly of the genus Cordyceps and the broad diversity of the mostly arthropod-pathogenic lineages of Hypocreales. The other two cordyceps-like families, Cordycipitaceae and Clavicipitaceae, will be revised taxonomically elsewhere. Historically, many species were placed in Cordyceps, but other genera have been described in this family as well, including several based on anamorphic features. Currently there are 24 generic names in use across both asexual and sexual life stages for species of Ophiocordycipitaceae. To reflect changes in Art. 59 in the International Code of Nomenclature for algae, fungi, and plants (ICN), we propose to protect and to suppress names within Ophiocordycipitaceae, and to present taxonomic revisions in the genus Tolypocladium, based on rigorous and extensively sampled molecular phylogenetic analyses. When approaching this task, we considered the principles of priority, monophyly, minimizing taxonomic revisions, and the practical utility of these fungi within the wider biological research community.

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“…While the mechanism of action for the most toxic lehualides has heretofore not been elucidated, their common pyrone structure is reminiscent of the pyridine core of piericidin A1 and the quinone of ubiquinone (Figure B). Related γ-pyrone moieties are found in several other cytotoxic natural products (Figure C) − that have a wide variety of activities as insecticidal, anticancer, antifungal, antibacterial and immunosuppressive agents. − Some of these compounds have been shown to block the voltage-gated potassium channel Kv1.3 and to potently inhibit the mitochondrial electron transport chain protein NADH-ubiquinone reductase (complex I), with IC 50 ’s as low as 0.3 nM (verticipyrone analogues) . Finally, germane to our studies, a subset of potent complex I inhibitors have received attention as selective antitumor agents, yet the mechanism responsible for this activity has not been resolved. , …”

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confidence: 59%

Synthesis and SAR of Lehualide B: A Marine-Derived Natural Product with Potent Anti-Multiple Myeloma Activity

et al. 2013

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We report a concise and convergent laboratory synthesis of the rare marine natural product lehualide B that has led to the discovery that: (1) this compound has low nanomolar activity against human multiple myeloma cells, and (2) the anti-cancer effects of lehualide B and its analogs are selective (i.e., they are ~ two to three orders of magnitude less toxic to human breast cancer cells). Synthetic lehualide B is shown to be an effective inhibitor of complex I of the mitochondrial electron transport chain, with potency similar to that observed for the terrestrial natural products piericidin A1 and rotenone – an observation that led to the discovery that piericidin A1 is also selectively cytotoxic toward human multiple myeloma cells. Interestingly, synthetic derivatives of lehualide B that resemble verticipyrone (an established complex I inhibitor composed of a γ-pyrone and a simple mono-unsaturated hydrophobic chain) lack the potent anti-myeloma activity of the natural product. Finally, the synthesis and evaluation of a collection of lehualide-inspired analogs led to the elucidation of structure-activity relationships for this rare natural product that established important roles for the substituted γ-pyrone head group and the skipped polyene side chain.

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Chaunopycnis pustulata sp. nov., a new clavicipitalean anamorph producing metabolites that modulate potassium ion channels

Cited by 22 publications

References 38 publications

From pattern to process: species and functional diversity in fungal endophytes of Abies beshanzuensis

From pattern to process: species and functional diversity in fungal endophytes of Abies beshanzuensis

Phylogenetic-based nomenclatural proposals for Ophiocordycipitaceae (Hypocreales) with new combinations in Tolypocladium

Synthesis and SAR of Lehualide B: A Marine-Derived Natural Product with Potent Anti-Multiple Myeloma Activity

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