Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation

Shanmuganathan, Sivasankar; Angayarkanni, Narayanasamy

doi:10.1016/j.mvr.2018.09.001

Cited by 14 publications

(5 citation statements)

References 24 publications

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“…in addition, FGFr2 has recently been identified as a therapeutic target for carcinoma owing to its association with tumorigenesis (43)(44)(45). Studies have reported that FGFr2 promotes the proliferation of stem cells (46,47) and that a novel circular rna of FGFr2 may serve a role in enhancing skeletal muscle proliferation and differentiation by targeting mir-133a-5p and mir-29b-1-5p (6). a recent study has revealed that mir-142-3p suppresses the induction of the FGFr2-driven oncogenic process by directly binding transient receptor potential ankyrin-1 (TrPa1) (20).…”

Section: Discussionmentioning

confidence: 99%

miR‑217‑5p regulates myogenesis in skeletal muscle stem cells by targeting FGFR2

et al. 2020

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has been implicated in cell proliferation; however, its role in skeletal muscle stem cells (SkMScs) remains unknown. The present study aimed to explore the roles of mir-217-5p in the biological characteristics of SkMSCs. SkMSCs were identified by cell surface markers using flow cytometry. The present study observed that mir-217-5p mimics accelerated the proliferation and suppressed the differentiation in SkMScs. in addition, the results of the present study revealed that fibroblast growth factor receptor 2 (FGFr2) was a target of mir-217-5p, as mir-217-5p bound directly to the 3'-untranslated region of FGFr2 mrna, resulting in increased FGFr2 mrna and protein levels. in addition, the present study suppressed the expression of FGFr2 in SkMScs using a selective FGFr inhibitor AZD4547 and detected the efficiency of inhibition by reverse transcription-quantitative Pcr and western blotting. mir-217-5p levels were positively associated with FGFr2 expression, which was upregulated and accelerated the proliferation of SkMScs compared with that of the mir-nc group. collectively, these results demonstrated that mir-217-5p may act as a myogenesis promoter in SkMScs by directly targeting FGFr2 and may regulate the myogenesis of these cells.

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Section: Discussionmentioning

confidence: 99%

miR‑217‑5p regulates myogenesis in skeletal muscle stem cells by targeting FGFR2

et al. 2020

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“…Compounds 20 , 30 , and 33 which have HHDP moiety decreased the ratio of MMPs/TIMPs to develop skin ageing [190]. Compound 48 was confirmed to inhibit TGF-beta 1-induced antifibrotic activity in choroid-retinal endothelial cells (RF/6A) [191] and inhibit TNF alpha induced proangiogenic and proinflammatory activities in retinal capillary endothelial cells [192].…”

Section: Biological Activitymentioning

confidence: 99%

A Comprehensive Review of the Structure Elucidation of Tannins from Terminalia Linn.

Zhang

Liang

Zhou

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Objectives Tannins with complex structures are important plant resources, which are abundant in the genus Terminalia. Various Terminalia species have been playing an important role in traditional medicine system. A systematic scoping review of Terminalia Linn. research literature for tannins was conducted to summarize the structures of tannins and analysis fragmentation pathway characteristics, which could provide references for the structural analysis of tannins from Terminalia Linn. Methods After an update of the literature search up to September 2018, the terms of Terminalia in all publications were analyzed. Electronic searches were conducted in scifinder and PubMed, and the information from 197 articles in all with regard to the tannin structure study was extracted. Results The compounds of 82 tannins from the genus Terminalia were reviewed. According to the structural differences, they can be divided into three categories, hydrolysable tannins, condensed tannins, and complex tannins, respectively. The fragmentation pathways of 46 identified tannins were analyzed, and the fragmentation rules of tannins were speculated according to different types. Conclusion This review has attracted attention to the active substances in this species such as the tannins summarized in further study. How to improve the extraction and purification technology of tannins from genus Terminalia is an urgent problem to be solved.

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“…In high glucose-induced HRCECs, the use of blueberry anthocyanin extract (BAE) and malvidin-3-glucoside (Mv-3-glc) controlled angiogenesis by reducing the content of VEGF and protein kinase B-1 (Akt) [ 16 ]. Chebulagic acid (CA), chebulinic acid (CI), and gallic acid (GA) are the active compounds in the alcoholic extract of Triphala, which suppresses the transmission of epithelial cells to the mesenchymal cells in retinal pigment cells [ 29 ]. In RF/6A cells under TNF- α , induced conditions intake of these three phytochemicals reduced matrix metalloprotease-9 (MMP-9) expression and angiogenic activity.…”

Section: Antiangiogenic Phytochemicals Against Drmentioning

confidence: 99%

Nature against Diabetic Retinopathy: A Review on Antiangiogenic, Antioxidant, and Anti-Inflammatory Phytochemicals

Tabari

Mirjalili

Khoshhal

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background and Purpose. Diabetes mellitus (DM), hyperglycemia, and hypertension can result in diabetic retinopathy (DR), which is a major cause of blindness on a global scale. Development of DR is associated with decreased endothelial cells, increased basal membrane thickness, permeation of the retinal blood barrier, and neovascularization in patients. The purpose of the present review is to provide an overview of the findings regarding applications of phytochemicals for DR treatment and could be a beneficial resource for further clinical studies and also a basis for pharmaceutical purposes for drug design. Materials and Methods. A narrative literature review was performed from electronic databases including Web of Science, PubMed, and Scopus to analyze the effects of different phytochemicals to prevent or treat oxidation, angiogenesis, and inflammation in diabetic retinopathy. The inclusion criteria were original studies, which included the effects of different phytochemicals on diabetic retinopathy. The exclusion criteria included studies other than original articles, studies which assessed the effects of phytochemicals on nondiabetic retinopathy, and studies which used phytochemical-rich extracts. Results and Conclusions. Studies have shown that increased levels of inflammatory cytokines, angiogenic, and oxidative stress factors are involved in the progression and pathogenesis of DR. Therefore, phytochemicals with their anti-inflammatory, antiangiogenic, and antioxidant properties can prevent DR progression and retinal damage through various cellular mechanisms. It is also shown that some phytochemicals can simultaneously affect the inflammation, oxidation, and angiogenesis in DR.

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Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation

Cited by 14 publications

References 24 publications

miR‑217‑5p regulates myogenesis in skeletal muscle stem cells by targeting FGFR2

miR‑217‑5p regulates myogenesis in skeletal muscle stem cells by targeting FGFR2

A Comprehensive Review of the Structure Elucidation of Tannins from Terminalia Linn.

Nature against Diabetic Retinopathy: A Review on Antiangiogenic, Antioxidant, and Anti-Inflammatory Phytochemicals

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