Chelating ability and biological activity of hesperetin Schiff base

Łodyga-Chruścińska, Elżbieta; Symonowicz, Marzena; Sykuła, Anna; Bujacz, A.; Garribba, Eugenio; Rowińska‐Żyrek, Magdalena; Ołdziej, Stanisław; Klewicka, Elżbieta; Janicka, Magdalena; Królewska, Karolina; Cieślak, Marcin; Brodowska, Katarzyna; Chruściński, Longin

doi:10.1016/j.jinorgbio.2014.11.005

Cited by 25 publications

(23 citation statements)

References 57 publications

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“…1. An analogous coupling with 14 N was recently observed for a Cu(II) complex of a hesperetin hydrazone ligand [5]. The value of 16.8 9 10…”

Section: Characterization Of Ntsc and Its Copper(ii) Complexsupporting

confidence: 67%

“…These values are slightly larger than those of well-known DNA intercalators, such as K b = 4. (dpt = 3-(pyrazin-yl)-as-triazino [5,6f]phenanthrene) [8]. The K b values show that the complexes bind to DNA more strongly than the free ligand.…”

Section: Interactions With Ct-dnamentioning

confidence: 99%

“…In addition, they can act as artificial nucleases. It is commonly known that Cu(II) complexes demonstrate an efficient DNA cleavage activity [5,6]. Thus, their cytotoxicity may be caused by their ability to bind and cleave DNA, leading to cell cycle arrest and apoptosis or generation of reactive oxygen species (ROS) which in turn it leads to cell death.…”

Section: Introductionmentioning

confidence: 99%

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Naringenin Schiff base: antioxidant activity, acid–base profile, and interactions with DNA

Brodowska

Sykuła

Garribba

et al. 2015

Transition Met Chem

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A Schiff base derived from naringenin (NTSC) and its complex with Cu(II) ([Cu(H 3 L)(OAc)]ÁH 2 O, Cu(II)-NTSC) have been synthesized and characterized by physicochemical and spectroscopic methods. EPR studies confirmed that nitrogen, oxygen, and sulfur are the donor atoms bound to Cu(II) in the complex. The geometry of the complex has been modelled using DFT methods. Furthermore, naringenin and NTSC were used for the formation of Cu(II) complexes in solution, for comparison of biological activities. Antioxidant studies confirmed better radical scavenging activity of both NTSC and its Cu(II) complex compared to naringenin. The interaction of these compounds with calf thymus DNA was monitored by UV-Vis spectroscopy.

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“…1. An analogous coupling with 14 N was recently observed for a Cu(II) complex of a hesperetin hydrazone ligand [5]. The value of 16.8 9 10…”

Section: Characterization Of Ntsc and Its Copper(ii) Complexsupporting

confidence: 67%

Section: Interactions With Ct-dnamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Naringenin Schiff base: antioxidant activity, acid–base profile, and interactions with DNA

Brodowska

Sykuła

Garribba

et al. 2015

Transition Met Chem

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“…In addition to the expected biological properties of the Schiff base compounds, [30][31][32][33][34][35] binding the cobalt, copper and zinc atoms to this unit make these complexes a good prospect for biologically active compounds [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] (31)(32)(33)(34)(35) for zinc, 36-40 for cobalt, 41-45 for copper). For the study of the biological activities of new ligand (H 3 L Br ) and its complexes 1-3, docking calculations were run to investigate the possibility of interaction between these compounds with nine protein targets, including: BRAF kinase, cathepsin B (CatB), DNA gyrase, histone deacetylase (HDAC7), recombinant human albumin (rHA), ribonucleotide reductases (RNR), thioredoxin reductase (TrxR), thymidylate synthase (TS), topoisomerase II (Top II).…”

Section: Introductionmentioning

confidence: 99%

Theoretical and experimental investigation of anticancer activities of an acyclic and symmetrical compartmental Schiff base ligand and its Co(ii), Cu(ii) and Zn(ii) complexes

et al. 2018

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“…Also, Schiff base metal complexes have been widely studied because they have industrial and herbicidal applications 5 antitubercular activities 6 and chelating abilities which give it attracted remarkable attention 7 . Benzocaine was prepared by direct esterification of p-aminobenzoic acid with absolute ethanol, in the presence of sulfuric acid as dehydrating agent 8 .…”

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confidence: 99%

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2021

IJPSR

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benzoate Schiff base (C 16 H 15 NO 3 ), were synthesized and the structure was studied against the bases of X-ray, UV, visible, elemental analysis, 1 HNMR, IR and Mass spectroscopy. The crystal structure of the nickel complex has been determined by single crystal X-ray conformed the molecule, which indicate the compound is crystalline in the monoclinic C2 / c with a = 16.0916 (5) Å, b = 6.0315 (2) Å, c =29.0072 (10) Å, α = 90.00°, β= 101.856 (2)°, γ = 90.00°, V= 2755.3 (2) Å3 and Z = 8. Because of intra-molecular hydrogen bond involving the O atom of hydroxy group and N atom of azomethine group; the two benzene rings and azomethine group are practically coplanar. The Cobalt complex was prepared; the structure was characterized in the bases of IR spectra, elemental analysis, UV -visible, and conductance measurements. Also, the biological activity of both Schiff base and its Cobalt complex show that they are biologically active. INTRODUCTION:Schiff bases, which have an azomethine (imine) group (-C=N-) are usually prepared by condensation of a primary amine with an active carbonyl compound usually aldehyde or ketone 1 . Schiff bases as chelating agents (ligands) in the field of coordination chemistry and their metal complexes are of great interest for many years; because O, N, and S atoms play a vital role at the active sites of numerous metallobiomolecules in the coordination chemistry of d-block elements 2 in addition of their biological applications as anticancer, antimicrobial 3 , antifungal, antibacterial, and antiviral agents 4 .

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Chelating ability and biological activity of hesperetin Schiff base

Cited by 25 publications

References 57 publications

Naringenin Schiff base: antioxidant activity, acid–base profile, and interactions with DNA

Naringenin Schiff base: antioxidant activity, acid–base profile, and interactions with DNA

Theoretical and experimental investigation of anticancer activities of an acyclic and symmetrical compartmental Schiff base ligand and its Co(ii), Cu(ii) and Zn(ii) complexes

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