Chelation-assisted iridium-catalyzed hydroalkenylation and hydroarylation/cyclization with conjugated trienes

Abstract

While Ir-catalyzed hydroalkenylation of 1,3,5-trienes by alkenyl C–H activation of acrylamides delivers 1,4,6-trienes, benzamides and 1,3,5-trienes undergo tandem hydroarylation and intramolecular 1,2-addition to give tetrahydroisoquinolinones.

Enantioselective and Regiodivergent Synthesis of Dihydro-1,2-oxazines from Triene-Carbamates via Chiral Phosphoric Acid-Catalysis

“…Conjugated trienes are unique platforms for constructing complex molecules – given the presence of three double bonds that can potentially be individually functionalized . For instance, linear conjugated trienes have successfully been employed in intramolecular Diels–Alder (DA) reactions for synthesizing natural products .…”