Chelation Therapy Associated with Antioxidant Supplementation Can Decrease Oxidative Stress and Inflammation in Multiple Sclerosis: Preliminary Results

Vezzoli, Alessandra; Mrakic‐Sposta, Simona; Dellanoce, Cinzia; Montorsi, Michela; Vietti, Daniele; Ferrero, Maria Elena

doi:10.3390/antiox12071338

Cited by 5 publications

(2 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the antioxidant mechanism is not the only one responsible against toxicity, since binding may also be beneficial. The efficacy of treatment with antioxidants is strongly associated with chelation therapy for the treatment of several diseases [42]. Furthermore, antioxidants are not clinically adopted against heavy metal-induced cell damage, even though some recent outcomes suggested their protective effect [28].…”

Section: Phytochemicals Used To Ameliorate Heavy Metal-induced Toxicitymentioning

confidence: 99%

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Ceramella,

De Maio,

Basile

et al. 2024

Foods

View full text Add to dashboard Cite

Heavy metals (HMs) are natural elements present in the Earth’s crust, characterised by a high atomic mass and a density more than five times higher than water. Despite their origin from natural sources, extensive usage and processing of raw materials and their presence as silent poisons in our daily products and diets have drastically altered their biochemical balance, making them a threat to the environment and human health. Particularly, the food chain polluted with toxic metals represents a crucial route of human exposure. Therefore, the impact of HMs on human health has become a matter of concern because of the severe chronic effects induced by their excessive levels in the human body. Chelation therapy is an approved valid treatment for HM poisoning; however, despite the efficacy demonstrated by chelating agents, various dramatic side effects may occur. Numerous data demonstrate that dietary components and phytoantioxidants play a significant role in preventing or reducing the damage induced by HMs. This review summarises the role of various phytochemicals, plant and herbal extracts or probiotics in promoting human health by mitigating the toxic effects of different HMs.

show abstract

Section: Phytochemicals Used To Ameliorate Heavy Metal-induced Toxicitymentioning

confidence: 99%

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Ceramella,

De Maio,

Basile

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…Similarly, new advances in drug development include the introduction of improved drug posology [67][68][69], different routes of administration [70,71], new improved formulations, nanomedicines and other drug carriers, and drug combinations [71][72][73][74]. In the meantime, it should be noted that millions of patients choose to be treated in alternative medicine clinics using non-conventional treatments including a wide range of folk medicines, nutraceuticals and alternative medicinal drugs and combinations [75][76][77][78][79].…”

Section: Introductionmentioning

confidence: 99%

Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs

Kontoghiorghes

2023

IJMS

View full text Add to dashboard Cite

The design of clinical protocols and the selection of drugs with appropriate posology are critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be designed in all diseases including for millions of patients affected by excess iron deposition (EID) toxicity based on personalised medicine parameters, as well as many variations and limitations. EID is an adverse prognostic factor for all diseases and especially for millions of chronically red-blood-cell-transfused patients. Differences in iron chelation therapy posology cause disappointing results in neurodegenerative diseases at low doses, but lifesaving outcomes in thalassemia major (TM) when using higher doses. In particular, the transformation of TM from a fatal to a chronic disease has been achieved using effective doses of oral deferiprone (L1), which improved compliance and cleared excess toxic iron from the heart associated with increased mortality in TM. Furthermore, effective L1 and L1/deferoxamine combination posology resulted in the complete elimination of EID and the maintenance of normal iron store levels in TM. The selection of effective chelation protocols has been monitored by MRI T2* diagnosis for EID levels in different organs. Millions of other iron-loaded patients with sickle cell anemia, myelodysplasia and haemopoietic stem cell transplantation, or non-iron-loaded categories with EID in different organs could also benefit from such chelation therapy advances. Drawbacks of chelation therapy include drug toxicity in some patients and also the wide use of suboptimal chelation protocols, resulting in ineffective therapies. Drug metabolic effects, and interactions with other metals, drugs and dietary molecules also affected iron chelation therapy. Drug selection and the identification of effective or optimal dose protocols are essential for positive therapeutic outcomes in the use of chelating drugs in TM and other iron-loaded and non-iron-loaded conditions, as well as general iron toxicity.

show abstract

Environmental study and stress-related biomarkers modifications in a crew during analog astronaut mission EMMPOL 6

Giacon,

Mrakic-Sposta,

Bosco

et al. 2024

Eur J Appl Physiol

View full text Add to dashboard Cite

Purpose Human presence in space is increasingly frequent, but we must not forget that it is a hostile environment. We aimed to study the characteristics of experimental scenarios, to obtain data on human response to isolation, disruption of circadian rhythm and high levels of psychophysical stress. Methods In these experiments, we evaluated stress response in five young healthy subjects inside an earth-based moon-settlement-like habitat during a 1-week long analog astronaut mission. Wearable devices were used to monitor daily step count of the subjects, physical activity, heart rate during physical exercise and at rest, and sleep parameters. From saliva and urine samples collected every day at awakening, we studied oxy-inflammation biomarkers and hormones (stress and appetite) were studied too. Results At the end of the week, all subjects revealed an increase in oxidative stress and cortisol levels but no inflammation biomarkers variations, in conjunction with increasing time/daily exercise. Furthermore, a significant decrease in hours of sleep/day, sleep quality, and REM phase of sleep was recorded and correlated with the increase of reactive oxygen species. Conclusion Oxidative stress increased in a short period of time and may be attributed to the influence of psychological stress during confinement, as well as increased exercise and decreased amount of sleep. On a long-term basis, this could impact performance.

show abstract

Chelation Therapy Associated with Antioxidant Supplementation Can Decrease Oxidative Stress and Inflammation in Multiple Sclerosis: Preliminary Results

Cited by 5 publications

References 81 publications

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs

Environmental study and stress-related biomarkers modifications in a crew during analog astronaut mission EMMPOL 6

Contact Info

Product

Resources

About