Chelation therapy for atherosclerotic cardiovascular disease

Chelation therapy to prevent diabetes-associated cardiovascular events

“…By the 1970s, chelation therapy had firmly moved into the realm of complementary and alternative medicine (CAM). Clinical trials were eventually performed, but were too small individually or in aggregate to exclude a small-to-moderate beneficial effect [9–13]. Yet over the decades, patients continued to seek and receive chelation from practitioners.…”

“…A literature review in 2000 concluded that there was insufficient evidence for or against the practice [12]. This was followed by a more formal 2002 Cochrane Review again concluding that there was insufficient evidence to decide on the effectiveness of edetate sodium to treat atherosclerotic disease [13]. This conclusion sparked the interest of the NIH to release a RAF for a randomized double-blind, placebo-controlled trial to test the efficacy and safety of chelation therapy in patients with coronary artery disease.…”

Limb Preservation Using Edetate Disodium-based Chelation in Patients with Diabetes and Critical Limb Ischemia: An Open-label Pilot Study

“…Softer endpoints, such as ankle-brachial pressure index, walking distance, or pain-free walking were not improved. A Cochrane analysis in 2002 found there was not enough evidence to decide the effectiveness or ineffectiveness of chelation therapy [21]. Our review of this literature is that edetate disodium therapy of PAD is in equipoise, with similar quantities of flawed data falling on either side of the question.…”

Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure

“…In 2002, the Cochrane Collaborative 94 reported that there was insufficient evidence for or against chelation therapy to make a recommendation. Yet patients continued to seek, and practitioners to use, EDTA to prevent or treat atherosclerotic disease of the coronaries, carotids, and peripheral arteries.…”