Chelation Therapy in Older Patients With Thalassemia Major

Abstract

Departme nt s of Pe di atri c s , W a lte r Ree d Ar my Medi ca l Cente r , W a s h i ngton, D. C. and Uni formed Servi c e s Uni versity, Bethe sda , MD. In c re ased r e sp iratory compl icat i ons hav e been report ed in patient s treated s i mul t aneo us l y with amphot ericin-B (AB) a nd gr anul o cy t e (P HN) tran sfusi o ns. Aggre gat i on and s eque s trat i on of PMN' s 1n the micro va s cu l ature of the l ung has bee n pos tu la ted as a mechani s m. Thi s s t udy was de signed to see i f AB could agg regate PMN' s in vi t ro when t he cells wer e not eKpos ed to nylon wool fi be rs (NWF). Bl ood wa s obta i ned f ro m 30 a du l ts and PMN 's were con centra ted (10-7/ml) wi th Fi coll-Hypaque ce ntrifuga tion and