2023
DOI: 10.1021/acs.iecr.2c04378
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Chelator-Free Radiolabeling with Theoretical Insights and Preclinical Evaluation of Citrate-Functionalized Hydroxyapatite Nanospheres for Potential Use as Radionanomedicine

Abstract: Biomimetic hydroxyapatite nanoparticles (HAnps) are among the few nanostructured materials used clinically as potential carriers of drugs and biomolecules. Moreover, they have strong affinity toward lanthanide cations (such as Sm+3, Lu+3, Ho+3, etc.), which provides the scope for robust chelator-free radiolabeling with suitable lanthanide radioisotopes. Therefore, this nanoplatform can be used as a carrier of a cytotoxic payload of therapeutic radioisotopes. In the present study, HAnps were synthesized by the … Show more

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Cited by 4 publications
(1 citation statement)
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“…Radiolabeling of NPs in absence of a chelator is an emerging concept in the field of nuclear medicine. In this strategy, a radionuclide is directly incorporated into the core, or on the surface, of the NPs without any external chelating agent. Thus, this method is straightforward and time efficient in comparison to chelator-based radiolabeling methods.…”
Section: Radiolabeling Methodsmentioning
confidence: 99%
“…Radiolabeling of NPs in absence of a chelator is an emerging concept in the field of nuclear medicine. In this strategy, a radionuclide is directly incorporated into the core, or on the surface, of the NPs without any external chelating agent. Thus, this method is straightforward and time efficient in comparison to chelator-based radiolabeling methods.…”
Section: Radiolabeling Methodsmentioning
confidence: 99%