Chelerythrine Ameliorates Pulmonary Fibrosis via Activating the Nrf2/ARE Signaling Pathway

Peng, Ling; Wen, Li; Shi, Qingfeng; Gao, Feng; Huang, Bin; Wang, Changming

doi:10.1007/s12013-021-00967-0

Cited by 10 publications

(6 citation statements)

References 40 publications

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“…In conclusion, this study reported that chelerythrine can significantly alleviate bleomycin-induced pulmonary fibrosis via activating the Nrf2/ARE signaling pathway. Results showed that chelerythrine can effectively reduce the expression levels of alpha-smooth muscle actin (α-SMA), fibronectin, and transforming growth factor-beta (TGF-β), increase the expression of Nrf2, hemeoxygenase-1 (HO-1), and quinone oxidoreductase (NQO1), upregulate the levels of superoxide dismutase (SOD) and glutathione (GSH), and also decrease the levels of hydroxyproline (HP) and 4-hydroxynonenal (4-HNE) [ 47 ].…”

Section: Chelerythrine Can Modulate Critical Process Involved In Sars-cov-2 Infectionmentioning

confidence: 99%

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Therapeutic potential of chelerythrine as a multi-purpose adjuvant for the treatment of COVID-19

et al. 2021

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Multifunctional nature of phytochemicals and their chemical diversity has attracted attention to develop leads originated from nature to fight COVID-19. Pharmacological activities of chelerythrine and its congeners have been studied and reported in the literature. This compound simultaneously has two key therapeutic effects for the treatment of COVID-19, antiviral and anti-inflammatory activities. Chelerythrine can prevent hyper-inflammatory immune response through regulating critical signaling pathways involved in SARS-CoV-2 infection, such as alteration in Nrf2, NF-κB, and p38 MAPK activities. In addition, chelerythrine has a strong protein kinase C-α/-β inhibitory activity suitable for cerebral vasospasm prevention and eryptosis reduction, as well as beneficial effects in suppressing pulmonary inflammation and fibrosis. In terms of antiviral activity, chelerythrine can fight with SARS-CoV-2 through various mechanisms, such as direct-acting mechanism, viral RNA-intercalation, and regulation of host-based antiviral targets. Although chelerythrine is toxic in vitro, the in vivo toxicity is significantly reduced due to its structural conversion to alkanolamine. Its multifunctional action makes chelerythrine a prominent compound for the treatment of COVID-19. Considering precautions related to the toxicity at higher doses, it is expected that this compound is useful in combination with proper antivirals to reduce the severity of COVID-19 symptoms.

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Section: Chelerythrine Can Modulate Critical Process Involved In Sars-cov-2 Infectionmentioning

confidence: 99%

“…Chelerythrine has beneficial effects in suppressing pulmonary inflammation and fibrosis, which may be useful in treating COVID-19 patients. These effects of chelerythrine have been considered and evaluated in a study by Ling Peng described above ( section 4.3 ) [ 47 ].…”

Section: Some Special Therapeutic Effects Of Chelerythrine For Covid-19 Patientsmentioning

confidence: 99%

Therapeutic potential of chelerythrine as a multi-purpose adjuvant for the treatment of COVID-19

et al. 2021

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“…The Keap1/Nrf2/ ARE signalling pathway is identified as one of the crucial signalling pathways involved in conferring protection against oxidative damage, inflammation, fibrosis, etc. [52][53][54] Based on the results of the present study, it can be concluded that the protective effect of MEAS against RILI might be attributed to the synergistic effect of the bioactive polyphenols in MEAS with antioxidant, anti-inflammatory, and anti-fibrotic potential via enhancing Nrf2 antioxidant response.…”

Section: Papermentioning

confidence: 63%

Amomum subulatum mitigates experimental thoracic radiation-induced lung injury by regulating antioxidant status and inflammatory responses

et al. 2023

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“…It was remarkable that the activity of SOD and GSH-Px, and content of MDA content were the important markers of animal antioxidant capacity (3). MCE have been shown antioxidant effects because of their richness in sanguinarine and chelerythrine (25,26). Wang et al reported that 50 mg/kg MCE containing more than 3.75% sanguinarine could significantly increase serum SOD activity and decrease MDA content in piglets (11).…”

Section: Figurementioning

confidence: 99%

The combination of macleaya extract and glucose oxidase improves the growth performance, antioxidant capacity, immune function and cecal microbiota of piglets

Chen,

Zhang,

et al. 2023

Front. Vet. Sci.

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This study aims to investigate the effects of macleaya extract and glucose oxidase combination (MGO) on growth performance, antioxidant capacity, immune function, and cecal microbiota in piglets. A total of 120 healthy 28-day-old weaned piglets were randomly divided into two treatments of six replicates. Piglets were either received a basal diet or a basal diet supplemented with 250 mg/kg MGO (2 g/kg sanguinarine, 1 g/kg chelerythrine, and 1 × 106 U/kg glucose oxidase). The results showed that MGO supplementation increased average daily gain (ADG) and decreased feed:gain ratio (F/G) (p < 0.05). MGO increased serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, and immunoglobulin G (IgG) content (p < 0.05), but decreased malondialdehyde (MDA) and interleukin 1β (IL-1β) content (p < 0.05). The jejunal mRNA expression of nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione peroxidase 1 (GPX1), and heme oxygenase 1 (HO-1) were increased in MGO group (p < 0.05), while that of kelch like ECH associated protein 1 (Keap1) was decreased (p < 0.05). The Firmicutes was significantly increased at phylum levels in MGO group (p < 0.05). In conclusion, 250 mg/kg MGO improved piglet growth, and regulated intestinal flora of piglets, which provided a theoretical basis for MGO as an alternative additive for antibiotics.

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Chelerythrine Ameliorates Pulmonary Fibrosis via Activating the Nrf2/ARE Signaling Pathway

Cited by 10 publications

References 40 publications

Therapeutic potential of chelerythrine as a multi-purpose adjuvant for the treatment of COVID-19

Therapeutic potential of chelerythrine as a multi-purpose adjuvant for the treatment of COVID-19

Amomum subulatum mitigates experimental thoracic radiation-induced lung injury by regulating antioxidant status and inflammatory responses

The combination of macleaya extract and glucose oxidase improves the growth performance, antioxidant capacity, immune function and cecal microbiota of piglets

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