Chelidonium majus: a rare reason for severe hepatotoxic reaction

Greving, I.; Meister, V.; Monnerjahn, C.; Müller, Katharina; B, May

doi:10.1002/(sici)1099-1557(199808)7:1+<s66::aid-pds349>3.3.co;2-7

Cited by 27 publications

(13 citation statements)

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“…The patients were not re-challenged. 42 A single case report of contact dermatitis in 38 Peptic ulcer (10) and Amalaki (9 g ⁄ day) or gel 4 Both treatments 1 non-ulcer dyspepsia (28) antacids (30 mL every 3 h) produced a significant reduction in symptom scores à Percentage of patients symptom-free.…”

Section: Clinical Trials Of Monopreparationsmentioning

confidence: 99%

Herbal medicinal products for non‐ulcer dyspepsia

Coon

Ernst

2002

Aliment Pharmacol Ther

121

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SUMMARYBackground: Non-ulcer dyspepsia is predominantly a self-managed condition, although it accounts for a significant number of general practitioner consultations and hospital referrals. Herbal medicinal products are often used for the relief of dyspeptic symptoms. Aims: To critically assess the evidence for and against herbal medicinal products for the treatment of nonulcer dyspepsia. Methods: Systematic searches were performed in six electronic databases and the reference lists located were checked for further relevant publications. No language restrictions were imposed. Experts in the field and manufacturers of identified herbal extracts were also contacted. All randomized clinical trials of herbal

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Section: Clinical Trials Of Monopreparationsmentioning

confidence: 99%

Herbal medicinal products for non‐ulcer dyspepsia

Coon

Ernst

2002

Aliment Pharmacol Ther

121

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“…In spite of all the pharmacological activities hypothesized and the belief that use of herbal drugs is safe, several hepatotoxic reactions have been described in the literature (Greving et al, 1998;Stickel et al, 2003;Hardeman et al, 2008). Usually, the patients showed the increase of liver function parameters, and liver biopsy revealed moderate to severe drug-induced hepatitis (Benninger et al, 1999;Menniti Ippolito et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment

Mazzanti

Sotto

Franchitto

et al. 2009

Journal of Ethnopharmacology

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“…Nevertheless the possibility of a celandine-drug interaction must be considered. When consumption of Greater celandine was interrupted, symptoms always regressed and liver parameters normalised until complete recover within 2 or 3 months (rarely after more than 5 months) without any specific therapy (Greving et al, 1998;Benninger et al, 1999;Crijns et al, 2002;Stickel et al, 2003;Rifai et al, 2006).…”

Section: Past Casesmentioning

confidence: 99%

“…Although the oral use of Greater celandine as antispasmodic is approved by the German Commission E (ESCOP, 2003), several cases of acute cholestatic hepatitis apparently related to its use have been reported (Greving et al, 1998;Benninger et al, 1999;Crijns et al, 2002;Stickel et al, 2003;Rifai et al, 2006).…”

Section: Introductionmentioning

confidence: 99%