2024
DOI: 10.1101/2024.02.13.580100
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ChemGLaM: Chemical-Genomics Language Models for Compound-Protein Interaction Prediction

Takuto Koyama,
Hayato Tsumura,
Shigeyuki Matsumoto
et al.

Abstract: Accurate prediction of compound-protein interaction (CPI) is of great importance for drug discovery. For creating generalizable CPI prediction deep learning (DL) models, the expansion of CPI data through experimental validation is crucial. However, the cost associated with these experimental validations is a bottleneck. Recently developed large language models (LLMs) such as chemical language models (CLMs) and protein language models (PLMs) have emerged as foundation models, demonstrating high generalization p… Show more

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