Chemical analysis and anti-proliferative activity of Campania Thymus Vulgaris essential oil

Catauro, Michelina; Bollino, Flavia; Tranquillo, Elisabetta; Sapio, Luigi; Illiano, Michela; Caiafa, Ilaria; Naviglio, Silvio

doi:10.1080/10412905.2017.1351405

Cited by 22 publications

(9 citation statements)

References 48 publications

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“…according to various studies on the chemical composition of EOs. Thymol and carvacrol are the main components of thyme EO [37]. Furthermore, the strong band identified in the spectra of S. aromaticum EO at 1512 cm −1 was found to belong to either eugenol or eugenol acetate, according to research conducted by Rodriguez et al in 2018 [41].…”

Section: Discussionmentioning

confidence: 88%

“…Many functional groups were identified for all EOs such as carboxylic acids (O-H), alcohols, ether, ester (C-O), anhydrides, alkanes (C-H), alkenes (C=C), and amide (C=O) [36]. The analysis of T. vulgaris EO spectra showed characteristic absorption bands at 3405 cm −1 corresponding to broad O-H stretching in hydration water or phenol and alcohol [37]. For instance, the strong bands at 2954, 2929, and 2878 cm −1 were attributed to asymmetrical and symmetrical C-H stretching vibrations in the functional groups of CH 2 and CH 3 (aliphatic group) and in aromatic rings (C-H aromatic) as well as the O-CH 3 bands in lignins, lipids, saccharides, and esters [38].…”

Section: Antifungal Activity Of Essential Oils On Mycelial Growth Und...mentioning

confidence: 99%

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In Vitro and In Vivo Antifungal Activities of Nine Commercial Essential Oils against Brown Rot in Apples

et al. 2021

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After harvest, numerous plant pathogenic fungi can infect fresh fruits during transit and storage. Although synthetic fungicides are often used to manage postharvest fruit diseases, their application may lead to problems such as the development of fungicide resistance and residues on fruits. In the present study, the antifungal potential of nine commercial essential oils (EOs) extracted from Eucalyptus radiata ssp. radiata, Mentha pulegium, Rosmarinus officinalis, Origanum compactum, Lavandula angustifolia, Syzygium aromaticum, Thymus vulgaris, Citrus aurantium, and Citrus sinensis were tested against the apple brown rot fungi Monilinia laxa and Monilinia fructigena at different concentrations in vitro (against mycelial growth and spore germination) and in vivo (on detached apple fruit and in semi-commercial postharvest conditions). In addition, fruit quality parameters were evaluated and the composition of the EOs was characterized by Fourier transform infrared (FT-IR) spectroscopy. In vitro results showed significant antifungal activity of all tested EOs on both fungal species. EOs from S. aromaticum were the most effective, whereby inhibition percentages ranged from 64.0 to 94.7% against M. laxa and from 63.9 to 94.4% against M. fructigena for the concentrations 12.5 and 100 µL/mL, respectively, with an EC50 of 6.74 µL/mL for M. laxa and 10.1 µL/mL for M. fructigena. The higher concentrations tested of S. aromaticum, T. vulgaris, C. aurantium, and C. sinensis EOs significantly reduced spore germination, brown rot incidence, and lesion diameter. Evaluation of the treatments during storage for 20 days at 4 °C on apple fruit quality parameters demonstrated the preservation of the fruit quality characteristics studied (weight loss, total soluble solids, titratable acidity, firmness, and maturity index). FT-IR spectra obtained from all tested EO samples presented characteristic peaks and a high diversity of functional groups such as O–H groups, C–H bonds, and C–C stretching. The EOs examined here may have the potential for controlling postharvest fungal diseases of fruit such as brown rot.

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Section: Discussionmentioning

confidence: 88%

Section: Antifungal Activity Of Essential Oils On Mycelial Growth Und...mentioning

confidence: 99%

In Vitro and In Vivo Antifungal Activities of Nine Commercial Essential Oils against Brown Rot in Apples

et al. 2021

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“…The PANC-1, MDA-MB-231 and U2OS cell lines are well-established and widely used model systems of human pancreatic, triple negative breast cancer, and osteosarcoma cancer cells, respectively [ 40 , 41 , 42 , 43 , 44 , 45 ]. In order to evaluate the possible antitumor properties of CGA-containing SiO 2 /PEG hybrids, we firstly looked at their impact on the proliferation of PANC-1, MDA-MB-231 and U2OS cells.…”

Section: Resultsmentioning

confidence: 99%

Silica/Polyethylene Glycol Hybrid Materials Prepared by a Sol-Gel Method and Containing Chlorogenic Acid

et al. 2018

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Chlorogenic acid (CGA) is a very common dietary polyphenolic compound. CGA is becoming very attractive due to its potential use as preventive and therapeutic agent in many diseases, including cancer. Inorganic/organic hybrid materials are gaining considerable attention in the biomedical field. The sol-gel process provides a useful way to obtain functional organic/inorganic hybrids. The aim of this study was to synthesize silica/polyethylene glycol (PEG) hybrids with different percentages of CGA by sol-gel technique and to investigate their impact on the cancer cell proliferation. Synthesized materials have been chemically characterized through the FTIR spectroscopy and their bioactivity evaluated looking by SEM at their ability to produce a hydroxyapatite layer on their surface upon incubation with simulated body fluid (SBF). Finally, their effects on cell proliferation were studied in cell lines by direct cell number counting, MTT, flow cytometry-based cell-cycle and cell death assays, and immunoblotting experiments. Notably, we found that SiO2/PEG/CGA hybrids exhibit clear antiproliferative effects in different tumor, including breast cancer and osteosarcoma, cell lines in a CGA dependent manner, but not in normal cells. Overall, our results increase the evidence of CGA as a possible anticancer agent and illustrate the potential for clinical applications of sol-gel synthesized SiO2/PEG/CGA materials.

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“…Essential oils are refined solutions of volatile components with complex FTIR spectra arising due to the overlapping of individual component spectra and the mixing of multiple vibrational modes [26]. The vibrational frequencies, in wavenumbers, of the sample spectrum produced from the FTIR spectrometer were compared with those of an IR correlation chart [27]. A mid-range FTIR spectrum was plotted with wavenumbers ranging from 4,000 to 650 cm -1 as shown in Fig.…”

Section: Ftir Analysismentioning

confidence: 99%

Evaluation of Physiochemical Properties, Thermal Behavior and Phytopharmaceutical Potential of Citrus aurantium’s Essential Oil

Jha¹,

Shaikh²,

Tendulkar³

et al. 2022

EJMP

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The study investigates the therapeutic potential of the Citrus aurantium var. amara essential oil extracted from the blossoms of the bitter orange plant by examining its chemical composition, thermal stability, and potency against infectious disease-causing pathogens. Initially, the volatile components of the essential oil were evaluated by obtaining a chromatographic fingerprint using HPTLC and FTIR spectrum identification. Furthermore, a thermal profile of the essential oil was obtained using the thermogravimetric-differential thermal analysis and differential scanning calorimetric analysis. A predetermined set of antibiotic-resistant microorganisms were used to examine the antibacterial activity of the essential oil. Lastly, its anti-inflammatory activity was assessed using the albumin denaturation assay. The research concluded that the Citrus aurantium var. Amara essential oil exhibits potential therapeutic characteristics which can be further explored through in vivo studies.

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Chemical analysis and anti-proliferative activity of Campania Thymus Vulgaris essential oil

Cited by 22 publications

References 48 publications

In Vitro and In Vivo Antifungal Activities of Nine Commercial Essential Oils against Brown Rot in Apples

In Vitro and In Vivo Antifungal Activities of Nine Commercial Essential Oils against Brown Rot in Apples

Silica/Polyethylene Glycol Hybrid Materials Prepared by a Sol-Gel Method and Containing Chlorogenic Acid

Evaluation of Physiochemical Properties, Thermal Behavior and Phytopharmaceutical Potential of Citrus aurantium’s Essential Oil

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