2021
DOI: 10.1016/j.heliyon.2021.e06292
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Chemical analysis and anticancer activity of sesterterpenoid from an endophytic fungus Hypomontagnella monticulosa Zg15SU and its host Zingiber griffithii Baker

Abstract: Zingiber griffithii Baker is one of the native Zingiberaceous species in a tropical forest of North Sumatra, Indonesia. Zingiberaceous species have been intensively studied and reported as herbal ingredients in ethnomedicine and currently their endophytic fungal associates were studied for pharmacological importance. Fifteen endophytic fungi were isolated from Zingiber griffithii following morphological and molecular characterization. All isolates exhibited antibacterial prope… Show more

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Cited by 29 publications
(21 citation statements)
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“…The association of endophytic fungi with aromatic and medicinal plants is considered to be the prominent source for producing volatile organic or terpenoid compounds [24,25] and they show potential bioactivity and are hence used in pharmaceutical industries [26,27]. The biosynthetic potential of endophytes in producing terpenoid compounds similar to the host plant has gained a lot of commercial importance.…”
Section: Introductionmentioning
confidence: 99%
“…The association of endophytic fungi with aromatic and medicinal plants is considered to be the prominent source for producing volatile organic or terpenoid compounds [24,25] and they show potential bioactivity and are hence used in pharmaceutical industries [26,27]. The biosynthetic potential of endophytes in producing terpenoid compounds similar to the host plant has gained a lot of commercial importance.…”
Section: Introductionmentioning
confidence: 99%
“…The lactone 7 is a valuable intermediate to access highly functionalized scalaranes on flexible manipulation of its functional groups. In our hands, the hydrogenation of the double bond delivered the 17-oxo-20-norscalaran-12α,19-O-lactone (8).…”
Section: Resultsmentioning
confidence: 83%
“…Marine organisms such as sponges or mollusks represent the main source for the scalaranic sesterterpenoids' isolation [3][4][5][6]. Some recent works report their isolation also from terrestrial plants [7] and fungi [8], thus keeping the focus and the scientific interest towards such compounds. The last 5 years witnessed more than 30 high impact publications connected to scalaranes [9].…”
Section: Introductionmentioning
confidence: 99%
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“…Aktivitas antibakteri terhadap S. aureus dan E. coli juga pernah dilakukan oleh Lutfia et al (2021) dengan menguji aktivitas antibakteri H. monticulosa yang diisolasi dari tanaman Z. griffithii. Hasil penelitian tersebut menunjukkan bahwa H. monticulosa memiliki aktivitas antibakteri yang sangat kuat terhadap bakteri S. aureus dan E. coli yang ditunjukkan dengan nilai diameter zona hambat secara berturut-turut yaitu 24 ± 3,96 mm dan 26,83 ± 1,56 mm.…”
Section: Efektivitas Antibakteri Yang Dihasilkan Oleh Jamur Endofit Dari Tanaman Marga Curcuma Dan Zingiberunclassified