Chemical Analysis of &amp;lt;i&amp;gt;Carica papaya&amp;lt;/i&amp;gt; L. Crude Latex

Macalood, Jeana S.; Vicente, Helen; Boniao, Renato; Gorospe, Jessie G.; Roa, Elnor C.

doi:10.4236/ajps.2013.410240

Cited by 37 publications

(25 citation statements)

References 30 publications

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“…PIs were isolated from Scopolia japonica cultured cells and these were found to have potential inhibitory activity against trypsin, chymotrypsin, kallikrein, plasmin, and pepsin but could not inhibit pain using synthetic or natural substrates (Sakato et al, 1975). Proteases like papain from Carica papaya L. has been used in different industrial processes including pharmaceutical process (Macalood et al, 2013). BBI like inhibitors were also isolated from sunflower (sunflower trypsin inhibitor-1; Luckett et al, 1999; Korsinczky et al, 2001; Marx et al, 2003; Lęgowska et al, 2010) and peanut ( Arachis hypogaea L.; Tur Sinal et al, 1972; Norioka and Ikenaka, 1983; Suzuki et al, 1987).…”

Section: Roles Of Plant Protease Inhibitors In Health and Disease Conmentioning

confidence: 99%

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy

2016

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Plants are known to have many secondary metabolites and phytochemical compounds which are highly explored at biochemical and molecular genetics level and exploited enormously in the human health care sector. However, there are other less explored small molecular weight proteins, which inhibit proteases/proteinases. Plants are good sources of protease inhibitors (PIs) which protect them against diseases, insects, pests, and herbivores. In the past, proteinaceous PIs were considered primarily as protein-degrading enzymes. Nevertheless, this view has significantly changed and PIs are now treated as very important signaling molecules in many biological activities such as inflammation, apoptosis, blood clotting and hormone processing. In recent years, PIs have been examined extensively as therapeutic agents, primarily to deal with various human cancers. Interestingly, many plant-based PIs are also found to be effective against cardiovascular diseases, osteoporosis, inflammatory diseases and neurological disorders. Several plant PIs are under further evaluation in in vitro clinical trials. Among all types of PIs, Bowman-Birk inhibitors (BBI) have been studied extensively in the treatment of many diseases, especially in the field of cancer prevention. So far, crops such as beans, potatoes, barley, squash, millet, wheat, buckwheat, groundnut, chickpea, pigeonpea, corn, and pineapple have been identified as good sources of PIs. The PI content of such foods has a significant influence on human health disorders, particularly in the regions where people mostly depend on these kind of foods. These natural PIs vary in concentration, protease specificity, heat stability, and sometimes several PIs may be present in the same species or tissue. However, it is important to carry out individual studies to identify the potential effects of each PI on human health. PIs in plants make them incredible sources to determine novel PIs with specific pharmacological and therapeutic effects due to their peculiarity and superabundance.

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Section: Roles Of Plant Protease Inhibitors In Health and Disease Conmentioning

confidence: 99%

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy

2016

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“…Both the heat required for removing the moisture as well as the electricity necessary for driving the fans are generated in the most cases by solar energy only [29]. In addition to the pre-treatment of the product, the weather conditions have the biggest influence on the capacity of product that can be dried within a certain time period.…”

Section: Early Work On Solar Drying In Indiamentioning

confidence: 99%

A Review on Solar Drying of Agricultural Produce

Tiwari¹

2016

J Food Process Technol

118

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“…The calcium and alkaloids (protein precipitates) contained in this plant extract are known to be involved in the precipitation of coagulation factors (Taofeeq et al, 2008) which promotes clotting in rats. Carica papaya preparations can be efficiently used in tissue burn (Macalood et al, 2013) and microbial helmintic infection. Dried latex contained higher amount of crude protein, crude fat and crude fibre (Macalood et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Carica papaya preparations can be efficiently used in tissue burn (Macalood et al, 2013) and microbial helmintic infection. Dried latex contained higher amount of crude protein, crude fat and crude fibre (Macalood et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Effect of Pawpaw (Carica papaya) Latex on the Haemostatic Mechanism and Biochemical Profile of Male Albino Wistar Rats

Oguwike¹,

Nwafia²,

Nwozor³

et al. 2017

GJMS

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Extracts of roots, stem, bark, leaves and sap of some medicinal plants have been known to have effect against the most dreaded pathogenic organism like the bacteria, Fungi, viruses (Russel et al, 1997). Soldiers need training, men and women do engage in exercises, children play in the field, most times people are not allowed to partake in their trainings, exercises or play due to bleeding from minor injuries which could be arrested using simple remedies from plants that could be found around the bush. Hence the effect of pawpaw (Carica papaya) latex on the haemostatic mechanism and biochemical profile of male albino wistar rats was studied to show the ability of Carica papaya latex to enhance haemostatic mechanism and stop bleeding.Forty (40) male albino rats weighing 200-250g were selected for the study. Group 1 (10 rats) is the control group. Group 2 (10 rats) received topical application of the latex after wound laceration, Group 3 (10 rats) was fed orally (Enteral) with the latex for 5 days, while Group 4 (10 rats) was injected (Parenteral) with the latex (0.5ml) for 5 days. Thereafter, blood samples were collected from Groups 1, 3 and 4 for analysis such as Full blood count, Platelet count, Prothrombin time test, Partial thromboplastin time test, bleeding time, clotting time, biochemical test such as serum total bilirubin, conjugated bilirubin, alkaline phosphatise, aspartate transaminase and alanin transaminase.Calcium and alkaloids (protein precipitates) was discovered present in the latex of Carica papaya. They are known to be involved in the precipitation of coagulation factors (Tafeeq, et al 2008) which promotes clotting in rats. The latex of Carica papaya reduced haemoglobin concentration, packed cell volume and white blood cell count significantly (p<0.05) but the platelet count was very high (p<0.05). It also increased the total bilirubin, conjugated bilirubin and the liver enzymes but shortened bleeding and clotting times in vitro. It could be deduced that the presence of calcium and papain helped to reduce the bleeding and clotting times.

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Chemical Analysis of <i>Carica papaya</i> L. Crude Latex

Cited by 37 publications

References 30 publications

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy

A Review on Solar Drying of Agricultural Produce

Effect of Pawpaw (Carica papaya) Latex on the Haemostatic Mechanism and Biochemical Profile of Male Albino Wistar Rats

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