Chemical analysis of Astragalus mongholicus polysaccharides and antioxidant activity of the polysaccharides

Yan, Hui; Xie, Yupeng; Sun, Shi-Guang; Sun, Xiaodi; Ren, Fengxia; Shi, Qiyun; Wang, Suhui; Zhang, Weidong; Li, Xiumin; Zhang, Jing

doi:10.1016/j.carbpol.2010.05.026

Cited by 65 publications

(32 citation statements)

References 12 publications

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“…Since NF-B activity is identified to be regulated by alterations in the intracellular redox state, PCV2 replication is associated with alteration in NF-B activity induced by ROS [20]. It is possible that APS blocked the activation of NF-B induced by the replication of PCV2.…”

Section: Aps Blocked the Activation Of Nf-äb Pathwaymentioning

confidence: 96%

“…PCV2 infection induce oxidative stress in RAW264.7 cells, the negative effects of which could be reduced by sophora subprosrate polysaccharide [18]. APS can reduce oxidative stress occurs [20], which imply that APS is likely to resist the replication of PCV2 by its antioxidant activity. Interaction between PCV2 infection and intracellular redox status, which is associated with the alteration in NF-B pathway induced by oxidative stress [21].…”

Section: Introductionmentioning

confidence: 99%

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Astragalus polysaccharides inhibits PCV2 replication by inhibiting oxidative stress and blocking NF-κB pathway

Xue

Gan

Zhang

et al. 2015

International Journal of Biological Macromolecules

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Section: Aps Blocked the Activation Of Nf-äb Pathwaymentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Astragalus polysaccharides inhibits PCV2 replication by inhibiting oxidative stress and blocking NF-κB pathway

Xue

Gan

Zhang

et al. 2015

International Journal of Biological Macromolecules

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“…It has been reported that polysaccharide extracted from AM exhibited high biological activities, such as modulating immune functions, inhibiting tumor growth and improving insulin sensitivity and antioxidant activities (Yan et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Extraction, isolation, characterization and antioxidant activity of polysaccharides from Astragalus membranaceus

Chen

Tan

Jin

et al. 2015

Industrial Crops and Products

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“…Astragalus polysaccharide (APS) is one of the active ingredients of Radix Astragali. It has been shown to exert various pharmacological activities, including antiinflammatory (Luo et al, 2015;Wei et al, 2016), antioxidant (Li et al, 2010;Yan et al, 2010), anti-diabetic (Liu et al, 2013), and anti-tumor activity (Yang et al, 2013). Furthermore, APS treatment ameliorated adjuvant-induced arthritis in rats in a dose-dependent manner (Jiang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of Astragalus polysaccharides on ovariectomy-induced osteoporosis in mice

Huo¹,

Sun²

2016

Genet. Mol. Res.

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ABSTRACT. Postmenopausal osteoporosis, a common type of osteoporosis in women, has become a serious public health issue. Astragalus polysaccharides (APS), possessing various pharmacological activities, are the active ingredients of Radix Astragali. It can be advantageous in the treatment of postmenopausal osteoporosis. In the present study, we evaluated the potential therapeutic effects of APS on postmenopausal osteoporosis by using a mice model induced by ovariectomy (OVX). Forty-eight female 6-week-old outbred ICR mice were randomly divided into six groups (N = 8): Sham group, OVX group, 17 b-estradiol (E2, 0.1 mg/kg)-treated OVX group, and APS (at three doses: 100, 200, and 400 mg/kg)-treated OVX groups. The effect of APS on the bone mineral density (BMD) was determined using dualenergy X-ray absorptiometry. The serum levels of receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), osteocalcin, and tumor necrosis factor (TNF)-a were measured using ELISA kits. The results revealed that APS exerted significant antiosteoporotic activity by increasing the BMD considerably in a dosedependent manner. APS treatment reduced the serum RANKL levels considerably and increased the serum OPG levels, thereby lowering the ratio of RANKL/OPG. Furthermore, APS also markedly reduced osteocalcin and TNF-a concentration in OVX-induced postmenopausal osteoporosis mice model. These results showed that APS exerts a protective effect on bone loss in OVX mice. The molecular mechanism underlying this effect be the reduction of bone resorption and inhibition of osteoclastogenesis. Our findings suggest that APS may be a potential strategy for the prevention and treatment of postmenopausal osteoporosis.

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Chemical analysis of Astragalus mongholicus polysaccharides and antioxidant activity of the polysaccharides

Cited by 65 publications

References 12 publications

Astragalus polysaccharides inhibits PCV2 replication by inhibiting oxidative stress and blocking NF-κB pathway

Astragalus polysaccharides inhibits PCV2 replication by inhibiting oxidative stress and blocking NF-κB pathway

Extraction, isolation, characterization and antioxidant activity of polysaccharides from Astragalus membranaceus

Effect of Astragalus polysaccharides on ovariectomy-induced osteoporosis in mice

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