Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method

Xu, Jiahao; Khor, K.A.

doi:10.1016/j.jinorgbio.2006.09.030

Cited by 109 publications

(70 citation statements)

References 27 publications

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“…Several studies have reported the positive effect of bioactive bioceramics on bone cells growth [3,4]. The ideal biomaterials for orthopedics should support the mechanical properties and biocompatibility during the period of implantation [8]. The problems that limit the application of hydroxyapatite include high decomposition rate in biological systems and in vivo solubility which led to less use of hydroxyapatite in long-term applications [9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Seyedmajidi¹,

Seyedmajidi²,

Alaghehmand³

et al. 2018

Eurasian J Anal Chem

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The aim of this study was to synthesize and characterization of hydroxyapatite/bioactive glass (HA/BG) nanocomposite foam and fluorapatite/bioactive glass (FA/BG) nanocomposite foam by gel casting method as cell scaffold for bone tissue engineering and evaluating their bioactivity using in vitro methods. Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Archimedes method and universal testing machine were used in order to evaluate specific surface area, phase composition, shape, size and interconnectivity of pores, size and shape of the constructed foam particles, porosity measurement and compressive strength of prepared nanocomposite foams, respectively. Mean particle size of HA/BG and FA/BG nanocomposite foams were 78 and 42 nm respectively with average pore size ranges was from 100 to 400 µm for two compositions. The maximum values of compressive strength and elastic modulus of nanocomposite foams were 0.22 and 17.8 Mpa for HA/BG and 0.13 and 22 MPa for FA/BG, respectively. The mean values of the apparent and true porosity were calculated 31 and 78% for HA/BG and 42 and 77% for FA/BG, respectively. The results of in vitro immersion of foams in simulated body fluid (SBF) demonstrate the formation of apatite on the surface of foams that indicating their bioactivity. The prepared nanocomposite foams in this research are appropriate substitutes for the bone defects in tissue engineering due to their characteristics. Moreover, using gel casting method to introduce these bioceramics provides the possibility to construct foams by molding or 3D printing in a desired shapes in accordance to patient's needs with high dimensional accuracy.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Seyedmajidi¹,

Seyedmajidi²,

Alaghehmand³

et al. 2018

Eurasian J Anal Chem

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“…8,9,13,31 Others investigated the influence of silicon on cell proliferation and osteogenic signaling in human mesenchymal stem cells (MSC) and could show transient osteogenic signals in MSC. 10,11 A silica gel-embedded, non-sintered nanocrystalline HA bone substitute (NanoBone ® ; Artoss GmbH, Rostock, Germany) with interconnecting pores from nanometer to millimeter range was recently developed and approved. 12 It was evaluated in several experimental studies as demonstrating faster bone formation, remodeling, and resorption rates after implantation, compared with other commercially available HA, tricalcium phosphate, or gelatin sponge materials.…”

Section: Introductionmentioning

confidence: 99%

Autologous serum improves bone formation in a primary stable silica-embedded nanohydroxyapatite bone substitute in combination with mesenchymal stem cells and rhBMP-2 in the sheep model

Boos

Weigand

Deschler

et al. 2014

IJN

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New therapeutic strategies are required for critical size bone defects, because the gold standard of transplanting autologous bone from an unharmed area of the body often leads to several severe side effects and disadvantages for the patient. For years, tissue engineering approaches have been seeking a stable, axially vascularized transplantable bone replacement suitable for transplantation into the recipient bed with pre-existing insufficient conditions. For this reason, the arteriovenous loop model was developed and various bone substitutes have been vascularized. However, it has not been possible thus far to engineer a primary stable and axially vascularized transplantable bone substitute. For that purpose, a primary stable silica-embedded nanohydroxyapatite (HA) bone substitute in combination with blood, bone marrow, expanded, or directly retransplanted mesenchymal stem cells, recombinant human bone morphogenetic protein 2 (rhBMP-2), and different carrier materials (fibrin, cell culture medium, autologous serum) was tested subcutaneously for 4 or 12 weeks in the sheep model. Autologous serum lead to an early matrix change during degradation of the bone substitute and formation of new bone tissue. The best results were achieved in the group combining mesenchymal stem cells expanded with 60 μg/mL rhBMP-2 in autologous serum. Better ingrowth of fibrovascular tissue could be detected in the autologous serum group compared with the control (fibrin). Osteoclastic activity indicating an active bone remodeling process was observed after 4 weeks, particularly in the group with autologous serum and after 12 weeks in every experimental group. This study clearly demonstrates the positive effects of autologous serum in combination with mesenchymal stem cells and rhBMP-2 on bone formation in a primary stable silica-embedded nano-HA bone grafting material in the sheep model. In further experiments, the results will be transferred to the sheep arteriovenous loop model in order to engineer an axially vascularized primary stable bone replacement in clinically relevant size for free transplantation.

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“…[24,25] and the powders with a particle size less than 20 lm, which are compose of nanoparticles in a needle-shape with a length of about 80-120 nm and a width of 20-30 nm, were used as HA matrix for the HA/TiO 2 nanocomposites. TiO 2 nanocrystal powders were prepared by using a sol-gel technique.…”

mentioning

confidence: 99%

“…Similarly, the spray dried HA particles, which have nanostructures in a needle-shape with a length of about 80-120 nm and a width of 20-30 nm as shown in Ref. [24] are employed as HA matrix at present study. Figure 2 shows the XRD patterns of the HA/TiO 2 composite SPS compacts with the addition of different molar content nanocrystalline TiO 2 powders and sintered at 1100°C.…”

mentioning

confidence: 99%

Effects of Titania Content and Sintering Temperature on Structural, Mechanical and Bioactive Behaviors of Titania Reinforced Hydroxyapatite Nanocomposites

Que

Khor

et al. 2008

Adv Eng Mater

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Hydroxyapatite (HA) is an attractive bioactive ceramic, which is a good candidate as implant material in clinical applications including bone spacers and fillers due to its biological and chemical similarity to the mineral composition of natural bone. [1][2][3][4][5][6] However, mechanical properties of low strength and high brittleness, which can lead to instability and unsatisfactory duration of the implant in the presence of body fluids and local loading, limit its application severely. Leading to the development of the biomaterial from monoliths to composites by controlling the volume fraction and distribution of the second phase in the composites, thus the properties of the composites can be tailored to meet the necessary mechanical and physiological requirements as an implant. One attractive way is to use bioactive HA as ceramic/ metal composites so as to achieve the necessary mechanical strength and bioactive properties at the same time, [7,8] which includes the addition of biocompatible glass into HA matrix. [9][10][11] Recently, researchers have proved that adhesive and cohesive strengths of the implants can be increased significantly by combining HA and TiO 2 as reinforcing additives, [12][13][14] and the addition of TiO 2 into HA has a major effect on the HA structure and a positive effect on the improvement of HA mechanical properties. Therefore, much attention has been given to the processing-microstructure-property relation of HA/TiO 2 composite biomaterials, but it is obvious that the addition of the different TiO 2 contents, different processing conditions and different preparing technique for the HA/TiO 2 composites can correspond to remarkably different microstructure, and hence, different properties and reinforcing mechanism.There are a variety of processing routes for preparing the HA/TiO 2 composite, such as sol-gel process, [15,16] electrochemical method, [17,18] thermal spray techniques, [19,20] etc. However, it is difficult to achieve a nanocomposite by abovementioned these methods. Considering that the use of nanoparticulate materials can attain more superior mechanical properties, [21] and nano-crystallized HA can promote osteoblast adhesion and proliferation as compared with conventionally crystallized HA, [22] as well as nano-sized HA can improve the sintering kinetics due to higher surface area. [23] The aim of the present study is to evaluate the effect of TiO 2 nanocrystal molar content and sintering temperature on the phase composition, microstructure, mechanical properties, and bioactive behaviors of the HA/TiO 2 nanocomposites obtained by a homogeneous mixing of nano-sized HA powders and nano-crystallized TiO 2 powders based on high-energy ball milling and spark plasma sintering (SPS) processes.Experimental HA powders were prepared by a wet chemical precipitation approach as reported in Refs. [24,25] and the powders with a particle size less than 20 lm, which are compose of nanoparticles in a needle-shape with a length of about 80-120 nm and a width of 20-30 nm, were used as HA m...

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Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method

Cited by 109 publications

References 27 publications

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Autologous serum improves bone formation in a primary stable silica-embedded nanohydroxyapatite bone substitute in combination with mesenchymal stem cells and rhBMP-2 in the sheep model

Effects of Titania Content and Sintering Temperature on Structural, Mechanical and Bioactive Behaviors of Titania Reinforced Hydroxyapatite Nanocomposites

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