Chemical Analysis of the Herbal Medicine Salviae miltiorrhizae Radix et Rhizoma (Danshen)

Abstract

Radix Salviae miltiorrhizae et Rhizoma, known as Danshen in China, is one of the most popular traditional Chinese medicines. Recently, there has been increasing scientific attention on Danshen for its remarkable bioactivities, such as promoting blood circulation, removing blood stasis, and clearing away heat. This review summarized the advances in chemical analysis of Danshen and its preparations since 2009. Representative established methods were reviewed, including spectroscopy, thin layer chromatography, gas chromatography, liquid chromatography (LC), liquid chromatography-mass spectrometry (LC-MS), capillary electrophoresis, electrochemistry, and bioanalysis. Especially the analysis of polysaccharides in Danshen was discussed for the first time. Some proposals were also put forward to benefit quality control of Danshen.

Comparative Analysis of the Major Chemical Constituents in Salvia miltiorrhiza Roots, Stems, Leaves and Flowers during Different Growth Periods by UPLC-TQ-MS/MS and HPLC-ELSD Methods

“…On account of the important medicinal value, S. miltiorrhiza , and its relevant preparations, are now drawing worldwide attention with a series of products, such as Danshen injection, Fufang Danshen tablets, tanshinone capsules [ 13 , 14 ], and the Fufang Danshen Dripping Pill, whose phase III clinical study were completed in 2016 [ 15 ]. It is estimated that the annual demand of S. miltiorrhiza was about 5000–7000 tons in recent decades, and that the yield of S. miltiorrhiza based on natural resources was insufficient and gradually replaced by artificial cultivation, hence, giving rise to the expansion of planting areas and an increase of production.…”

Evaluation of antigenotoxic potential of salvianolic acid B with hydrogen peroxide on human peripheral blood leukocytes in vitro

“…Koren kineske žalfije (Salviae miltiorrhizae radix) koristi se u Kini, Koreji, Japanu u tretmanu kardiovaskularnih, cerebrovaskularnih i hepatičkih bolesti, pneumonije, hroničnog nefritisa i vaskularnih komplikacija dijabetesa melitusa (9,10). Godine 1934. prvo je detektovan sastojak tanšinon IIa (11), a od tada je identifikovano i izolovano više od 100 sastojaka (12).…”

Shenlian Extract Against Myocardial Injury Induced by Ischemia Through the Regulation of NF-κB/IκB Signaling Axis

“…Furthermore, modern pharmacological studies have shown that S. miltiorrhiza Bunge also affects myocardial remodelling to improve myocardial infarction disease (Wang et al, 2018). The other ingredient, A. paniculata, has an anti-inflammation and detoxification effect (Pang et al, 2016;Zou et al, 2016), improving the hemodynamic and ventricular function against ischemic reperfusion injury (Ojha et al, 2012) and protecting endothelial cells (You et al, 2011).…”