Chemical Analysis Program for the Time of Flight Mass Spectrometry System

Kepceoğlu, Abdullah; Kılıç, Hamdi Şükür

doi:10.18100/ijamec.263976

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…We have applied PCA statistics to data obtained using the program developed by our group in MATLAB. Since the program has the ability to take data from oscilloscope and analyses in real time during the experiment simultaneously, the data acquisition process can be performed in microseconds, while the data analysis process using PCA statistic can be performed in a couple of minutes .…”

Section: Methodsmentioning

confidence: 99%

Discrimination of cancerous and healthy colon tissues: A new laser‐based method

Gündoğdu¹,

Alptekın

Karabağlı

et al. 2018

Lasers Surg Med

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Background Femtosecond (fs) Laser Ionisation Mass Spectrometry (fs‐LIMS) on colon tissues are described and investigated using ionization/fragmentation processes in details to present a new application in this study. Linear Time of Flight (L‐TOF) mass analyzer was utilized to investigate paraffin‐embedded human tissue in this study. The effect of fs laser intensity on the spectral characteristics was investigated and interpreted due to mass spectra obtained using 800 nm wavelength with 90 fs pulses at 1 kHz repetition rate. Objectives Mass spectra of tissues were recorded from L‐TOF system and then analyzed by performing a statistical approach called Principal Component Analysis (PCA). The fs‐LIMS method applied is proposed as a new and pioneering technology to analyze tissues using L‐TOF system, as a human free fast and reliable intra‐operative cancer diagnosis method for guiding surgeon to clean the edges of cancerous tissues to be applied during the surgical operation, for pathological examinations. Fs‐LIMS provides some unique diagnosis opportunities to investigate biochemical characteristics of cancerous tissues leading to obtain sensitive, fast, and reliable results. The analysis of tissue is based on distribution of molecular ion (m/z) peaks in low mass region (

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Section: Methodsmentioning

confidence: 99%

Discrimination of cancerous and healthy colon tissues: A new laser‐based method

Gündoğdu¹,

Alptekın

Karabağlı

et al. 2018

Lasers Surg Med

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“…Mass spectral resolution of the system measured to be ~200 at the m/z=100 amu. Data recording and analyses of the mass spectra were performed by using custom built MATLAB program [13]. Details of fs-L-TOF-MS system were described in elsewhere [14].…”

Section: Methodsmentioning

confidence: 99%

Analysis of the xylenol isomers by femtosecond laser time of flight mass spectrometry

et al. 2018

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Xylenol is a phenolic chemical substance having two methyl groups and one hydroxyl group attached to a benzene ring and has six isomers. 2,4-xylenol is the only isomer of the xylenol molecule that is in the liquid phase while the remaining isomers are all in crystal form at room temperature. In the scope of this study, we have experimentally investigated ionization and dissociation properties of xylenol isomers. All experiments were carried out by using a time of flight mass spectrometry (TOF-MS) system coupled with a femtosecond laser system. The laser pulse power-dependent multiphoton ionization of xylenol isomers was investigated by using IR (800 nm) femtosecond laser pulses having a pulse width of ∼90 fs in duration and laser intensities changing from 2.6 × 1013 to 2.6 × 1014 W/cm2. Theoretically, molecular orbitals (LUMO+1, LUMO, HOMO, HOMO–1), vertical and adiabatic ionization energies were calculated using density functional theory (DFT) with B3LYP functional and 6–311++G(d,p) basis set by following geometry optimization and performing conformational analysis.

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