The study examined land use effect on quality of plateau soils, using Ososo in Northern Edo State, Nigeria as a case study. The objectives were to examine the status of soils under the different land uses and evaluate variation in the physicochemical properties of soils among the investigated sites. A total of thirty-six soil samples were collected from secondary forest, cocoa plantation and quarry site at 0 - 15 and 15 - 30 cm depths. Soil quality indicators were analyzed in the laboratory, while data were examined by descriptive and inferential statistics. Due to the effect of mining activities, quarry site had lower mean values of soil organic matter, total organic carbon, total nitrogen, available phosphorous, effective cation exchange capacity, potassium, copper and manganese while iron, zinc and calcium were lower in secondary forest. However, Na and ECEC were higher in cocoa plantation. The study further revealed that though the examined land uses had varied effects on the soil properties; quarry site impacted the soil quality parameters more negatively compared to the secondary forest and cocoa plantation land use types. Significant variation (p < 0.05) in sand, clay and available phosphorous was detected in the topsoil of the different land uses. The research concluded that the status of the soil nutrients was low. To improve the quality of the plateau soils, liming and the use of animal droppings, town refuse ash and plant remains is recommended.