Chemical and biological evaluation of moxifloxacin-benzimidazole mixed ligands complexes: Anti-cancer and anti-oxidant activities

Refaat, Heba M.; El-Din, Doaa A. Noor

doi:10.1016/j.molstruc.2018.02.116

Cited by 28 publications

(7 citation statements)

References 39 publications

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“…5 Quinolone-metal chelates have the potential ability to interact with various metal ions and record biological activity towards different microorganisms. 6,7 Quinolones can be act as uni-dentate, bi-dentate and bridging chelates. In general, quinolones are coordinated in bi-dentate fashion, and this takes place through one oxygen atom upon deprotonation of the -COOH group and carbonyl oxygen atom ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, thermal, antimicrobial and electrochemical characterization of some novel Ru(iii), Pt(iv) and Ir(iii) complexes of pipemidic acid

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, thermal, antimicrobial and electrochemical characterization of some novel Ru(iii), Pt(iv) and Ir(iii) complexes of pipemidic acid

et al. 2018

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“…A set of new cobalt, nickel, zinc, and silver complexes with moxifloxacin and benzimidazole ligands was manufactured in the form of [M(MOX)(Ben)Cl(H 2 O)m].nH 2 O, as well as [Ag-(MOX)(Ben)] 3 .5H 2 O, n = 1, 1.5, 2, and m = 0 or 2. [114] According to the FT-IR spectra, Co(II), Ni(II), and Zn(II) ions coordinated with the moxifloxacin via the oxygen atoms of quinolone and carboxylate groups. However, Ag(I) ion was linked to the moxifloxacin by the nitrogen atom of the hydro-pyrrolopyridine moiety.…”

Section: Miscellaneous Anti-cancer Activitiesmentioning

confidence: 99%

Recent Advances in the Anticancer Applications of Benzimidazole Derivatives

Mavvaji,

Akkoc

2023

ChemistrySelect

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Cancer, one of the most deadly diseases worldwide, is still a crucial challenge to human well‐being. Hence, the design and development of modern protocols to cure diverse kinds of cancer seem highly necessary. On the other hand, benzimidazole, as an essential pharmacophore, exhibits various biological and therapeutic potency. This compound is well‐known for its pharmaceutical features, including antifungal, antiviral, antibacterial, and anticancer activities. Therefore, benzimidazole derivatives have played an essential role due to their outstanding anticancer capability, apoptotic effect, and inhibitory potential. In recent decades, numerous anticancer drug types of research have been concentrated on finding new and practical strategies for employing benzimidazole‐based compounds. This review focuses on the latest advancements and methodologies for exploiting various benzimidazole‐bearing compounds for the treatment of varied sorts of cancer, considering the mechanism of their function against cancer cell lines.

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“…Refaat et al [148] synthesized metal (II) ion complexes of 1 H ‐benzimidazole‐MOX (moxifloxacin) mixed ligands and tested them for their anti‐cancer action against MCF‐7, HCT, and HepG2 human cancer cell lines through viability assay method. The results showed that complexes of Ni (II) and ZN(II) displayed insignificant activity against MCF‐7 cell lines, whereas MCF‐7 cells exhibited growth inhibition on treatment with MOX and Ag(I), Co (II) complexes in a dose dependent manner (IC 50 = 35.4, 6.1, and 13.2 μg/ml, respectively).…”

Section: Benzimidazole As Target Oriented Anticancer Agentsmentioning

confidence: 99%

Benzimidazole based derivatives as anticancer agents: Structure activity relationship analysis for various targets

Satija

Sharma

Madan

et al. 2021

Journal of Heterocyclic Chem

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Benzimidazole, the benzo derivative of imidazole, is a class of bicyclic aromatic organic compound consisting of six‐membered benzene ring fused to five‐membered imidazole at 4‐ and 5‐positions of the imidazole ring. It is a vital pharmacophore of many biologically active heterocyclic compounds with a variety of pharmacological activities. Over the time, benzimidazole and its derivatives have evolved as vibrant heterocyclic systems due to their potency in a wide range of bioactive compounds like analgesics, antifungals, anti‐inflammatory, antihypertensives, proton pump inhibitors, anti‐HIV, antiviral, and so on. Multi‐drug resistance in cancer that led to the failure of many chemotherapeutic drugs is a major concern. Various approaches are being developed to overcome this problem. One of them is target based drug discovery, which is an effective method to develop a novel anticancer drug. To develop newer drugs, previously reported work needs to be studied. Keeping this in mind, last 5 years literature on benzimidazole used as anticancer agents has been reviewed and summarized in the paper herein. This review article along with the target of cancer also deal with structure activity relationship of various compounds having benzimidazole ring.

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Chemical and biological evaluation of moxifloxacin-benzimidazole mixed ligands complexes: Anti-cancer and anti-oxidant activities

Cited by 28 publications

References 39 publications

Synthesis, spectroscopic, thermal, antimicrobial and electrochemical characterization of some novel Ru(iii), Pt(iv) and Ir(iii) complexes of pipemidic acid

Synthesis, spectroscopic, thermal, antimicrobial and electrochemical characterization of some novel Ru(iii), Pt(iv) and Ir(iii) complexes of pipemidic acid

Recent Advances in the Anticancer Applications of Benzimidazole Derivatives

Benzimidazole based derivatives as anticancer agents: Structure activity relationship analysis for various targets

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