Chemical and Biological Investigation of Araucaria heterophylla Salisb. Resin

Abdel‐Sattar, Essam; Monem, Azza R. Abdel; Ezzat, Shahira M.; El-Halawany, Ali M.; Mouneir, Samar M.

doi:10.1515/znc-2009-11-1211

Cited by 27 publications

(23 citation statements)

References 27 publications

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“…The fractions obtained from the Grace Revelris system were analysed by HPLC–ELSD, and four of the fractions were found to be quite pure. The 1 H and 13 C NMR data for the pure fractions were compared with those in the literature, and the data were found to closely match the NMR data reported previously for the labdane diterpenes 13‐epitorulosal ( 1 ), acetyl‐13‐epi‐cupressic acid ( 2 ), 13‐epi‐cupressic acid ( 3 ) (Abdel‐Sattar et al ., ; Wen‐Chiung et al ., ) and the lignin (+) sesamin ( 4 ) (Figure ) (Christov et al ., ). In addition, the following analytical information was obtained: (i) eluted mainly in fraction 9 from the MPLC system, which had a weight of 14 mg, and it had an optical rotation of +14° (lit +35°); (ii) eluted mainly in fraction 10 from the MPLC system, which had a weight of 7 mg, and it had an optical rotation of +92°; (iii) eluted mainly in fraction 15 from the MPLC system, which had a weight of 102 mg, and it had an optical rotation of +55.5° (lit +57°); and (iv) eluted in fraction 7 when fractionation of open column fraction 3 was separated using the MPLC system, and it had a weight of 7 mg.…”

Section: Resultsmentioning

confidence: 99%

“…Some of these diterpenes, including compounds 1 and 3 , were isolated from Cretan propolis (Popova et al ., ) and tested against a range of bacteria against which they were found to have moderate activity. Compounds 2 and 3 were isolated from Araucaria heterophylla resin (Abdel‐Sattar et al ., ) and were tested against cancer cell lines. Compounds 2 and 3 were found to be quite cytotoxic having IC 50 values of 2.7 and 9.8 µg/mL against MCF7 breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

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The Isolation of Antiprotozoal Compounds from Libyan Propolis

Siheri

Igoli

Gray

et al. 2014

Phytotherapy Research

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Propolis is increasingly being explored as a source of biologically active compounds. Until now, there has been no study of Libyan propolis. Two samples were collected in North East Libya and tested for their activity against Trypanosoma brucei. Extracts from both samples had quite high activity. One of the samples was fractionated and yielded a number of active fractions. Three of the active fractions contained single compounds, which were found to be 13-epitorulosal, acetyl-13-epi-cupressic acid and 13-epi-cupressic acid, which have been described before in Mediterranean propolis. Two of the compounds had a minimum inhibitory concentration value of 1.56 µg/mL against T. brucei. The active fractions were also tested against macrophages infected with Leishmania donovani, and again moderate to strong activity was observed with the compounds having IC50 values in the range 5.1-21.9 µg/mL.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Isolation of Antiprotozoal Compounds from Libyan Propolis

Siheri

Igoli

Gray

et al. 2014

Phytotherapy Research

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“…Araucaria heterophylla Labda-8(17), 14-diene ; 13-epicupressic acid (37) ; 13-O-acetyl-13-epicupressic acid [24] Araucaria montana Abietanes(36) [21] Araucaria resinous 3-O-methylrhamnose(38) [25] …”

Section: Resultsmentioning

confidence: 99%

Phytochemical and Ethno-Pharmacological Review of the Genus Araucaria – Review

Aslam¹,

Choudhary²,

Uzair³

et al. 2013

Trop. J. Pharm Res

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Distribution, traditional uses, isolated chemical constituents and pharmacological activities of some common species of the genus Araucaria are reviewed in this paper. Almost 19 species belong to the genus, Araucaria. It is indigenous to North America. Biflavanoid, diterpene, phenyl propanoid and lignans are abundant in the genus. The most common pharmacological activity of Araucaria in modern medicines is anti-inflammatory. It also possesses other pharmacological activities such as antiulcer, antiviral, neuro-protective, anti-depressant and anti-coagulant. The aim of the present paper is to present an extensive review of the plants in this genus including their traditional uses, chemical constituents and pharmacology.

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“…They are reported to have antioxidant, anticytotoxic, antibacterial and antiulcerogenic effects. 8,25 The genus Prosopis belongs to the family Fabaceae with 45 species, consist of spines and grow into either trees or shrubs. This gum has been reported to have various bioactivities including anticancer, antioxidant etc.…”

Section: Introductionmentioning

confidence: 99%

Extraction, Purification, and Characterization of Polysaccharides of Araucaria heterophylla L and Prosopis chilensis L and Utilization of Polysaccharides in Nanocarrier Synthesis

Samrot¹,

Kudaiyappan²,

Bisyarah³

et al. 2020

IJN

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Background: Plant gums consist of polysaccharides which can be used in the preparation of nanocarriers and provide a wide application in pharmaceutical applications including as drug delivery agents and the matrices for drug release. The objectives of the study were to collect plant gums from Araucaria heterophylla L and Prosopis chilensis L and to extract and characterize their polysaccharides. Then to utilize these plant gum-derived polysaccharides for the formulation of nanocarriers to use for drug loading and to examine their purpose in drug delivery in vitro. Methods: Plant gum was collected, polysaccharide was extracted, purified, characterized using UV-Vis, FTIR, TGA and GCMS and subjected to various bioactive studies. The purified polysaccharide was used for making curcumin-loaded nanocarriers using STMP (sodium trimetaphosphate). Bioactivities were performed on the crude, purified and drugloaded nanocarriers. These polysaccharide-based nanocarriers were characterized using UV-Vis spectrophotometer, FTIR, SEM, and AFM. Drug release kinetics were performed for the drug-loaded nanocarriers. Results: The presence of glucose, xylose and sucrose was studied from the UV-Vis and GCMS analysis. Purified polysaccharides of both the plants showed antioxidant activity and also antibacterial activity against Bacillus sp. Purified polysaccharides were used for nanocarrier synthesis, where the size and shape of the nanocarriers were studied using SEM analysis and AFM analysis. The size of the drug-loaded nanocarriers was found to be around 200 nm. The curcumin-loaded nanocarriers were releasing curcumin slow and steady. Conclusion: The extracted pure polysaccharide of A. heterophylla and P. chilensis acted as good antioxidants and showed antibacterial activity against Bacillus sp. These polysaccharides were fabricated into curcumin-loaded nanocarriers whose size was below 200 nm. Both the drug-loaded nanocarriers synthesized using A. heterophylla and P. chilensis showed antibacterial activity with a steady drug release profile. Hence, these natural exudates can serve as biodegradable nanocarriers in drug delivery.

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Chemical and Biological Investigation of Araucaria heterophylla Salisb. Resin

Cited by 27 publications

References 27 publications

The Isolation of Antiprotozoal Compounds from Libyan Propolis

The Isolation of Antiprotozoal Compounds from Libyan Propolis

Phytochemical and Ethno-Pharmacological Review of the Genus <i>Araucaria</i> – Review

<p>Extraction, Purification, and Characterization of Polysaccharides of <em>Araucaria heterophylla</em> L and <em>Prosopis chilensis</em> L and Utilization of Polysaccharides in Nanocarrier Synthesis</p>

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