Chemical and molecular characterization of fifteen species from the Lantana (Verbenaceae) genus

Filho, José Guedes de Sena; Rabbani, Allívia Rouse Carregosa; Silva, Tânia Regina dos Santos; Silva, Ana Veruska Cruz da; Souza, Igor Azevedo; Santos, Maria José Bryanne Araujo; Jesus, Jemmyson Romário de; Nogueira, Paulo César de Lima; Duringer, Jennifer M.

doi:10.1016/j.bse.2012.07.024

Cited by 16 publications

(9 citation statements)

References 31 publications

(31 reference statements)

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“…(Morales and Paredes, 2014). Phytochemical studies with taxonomical interest are few and have been based mainly on the essential oil composition (Sena Filho et al, 2012;Satyal et al, 2016). Despite the important studies already done, there are many other species of Verbenaceae to analyze for their phenol composition and antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Foliar phenolic compounds of ten wild species of Verbenacea as antioxidants and specific chemomarkers

et al. 2017

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The family Verbenaceae hosts important species used in traditional medicine of many countries. The taxonomic controversies concerning the specific delimitation of several of its species make it difficult to guarantee the botanical origin of herbal preparations based on species of this family. To contribute to the development of both specific chemomarkers and a quality control tool to authenticate the botanical origin of herbal preparations of Verbenacea species, we determined the foliar HPLC-DAD phenolic profiles and the antioxidant properties of 10 wild species of this family occurring in Mexico. The contents of phenols and flavonoids varied significantly among species. Priva mexicana showed the highest levels of total phenolics (53.4 mg g -1 dry tissue) and Verbena carolina had the highest levels of flavonoids (17.89 mg g -1 dry tissue). Relevant antioxidant properties revealed by antiradical and reducing power were found for the analyzed species. These properties varied significantly in a species-dependent manner. The phenolic compounds accumulated were flavones and phenolic acids. Flavones were the only type of flavonoids found. The results of a cluster analysis showed that the compounds were accumulated in species-specific profiles. The phenolic profiles are proposed as valuable chemomarkers that can become a useful tool for the quality control concerning the botanical origin of herbal medicinal preparations based on the species analyzed. In addition, phenolic profiles could contribute importantly to solve the taxonomic controversies concerning species delimitation in the family Verbenaceae.Keywords: Verbenacea, antioxidant activity, chemomarkers, flavones, phenolic profiles. Compostos fenólicos das folhas de dez especies selvagem de Verbenaceae como antioxidantes e quimiomarcadores específicos ResumoA família Verbenaceae compreende importantes espécies utilizadas na medicina popular de muitos países. As dificuldades taxonômicas relativas à delimitação específica de muitas das suas espécies face difícil a verificar a origem botânico das preparações herbales baseadas nas espécies desta família. Para fazer uma contribuição ao desenvolvimento de indicadores taxonômicos e dum método de controle de qualidade para verificar a origem botânico de preparações herbales das espécies de Verbenaceae, os perfis fenólicos, obtidos pares HPLC-DAD, e as atividades antioxidantes das folhas de 10 espécies selvagens Mexicanas desta família foram determinados. Os conteúdos dos compostos fenólicos totais e dos flavonoides foram significativamente diferentes entre as espécies. Priva mexicana apresentou a maior quantidade de compostos fenólicos totais (53.4 mg g -1 amostra seca) e Verbena carolina apresentou a maior quantidade de flavonoides (17.89 mg g -1 amostra seca). Verifica-se importantes propriedades antioxidantes, como os resultados dos ensaios da capacidade antiradical e do poder redutor indicaram. As propriedades antioxidantes foram significativamente diferentes entre as espécies. Verificou-se que os compostos fe...

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Section: Introductionmentioning

confidence: 99%

Foliar phenolic compounds of ten wild species of Verbenacea as antioxidants and specific chemomarkers

et al. 2017

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“…Chemotaxonomy, or chemical variation in a group of compounds, is one of the tools used to define intra- and inter-specific variability in plants ( Sena Filho et al, 2007 , 2012 ; Duran-Peña et al, 2015 ). Our objective was to use the chemical profile in the four Vitex species we studied, plus 13 others from the literature, to develop a system for classification of plant specimens derived from this genus.…”

Section: Discussionmentioning

confidence: 99%

Volatile Metabolomic Composition of Vitex Species: Chemodiversity Insights and Acaricidal Activity

et al. 2017

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The Vitex genus (Lamiaceae) produces a plethora of metabolites that include ecdysteroids and terpenoids, some of which have demonstrated insect repellent properties. The volatile composition of several members of this genus has not been chemically defined, as many taxa are endemic to remote ecosystems. In this study, leaves were collected from the northeast of Brazil from Vitex capitata, V. megapotamica, V. gardneriana, and V. rufescens plants and examined for their chemical profile via GC-MS/FID of essential oil extracts. The analyses showed a diversity of terpenoids. Of particular note were seven-member ring sesquiterpenes which were present in great abundance; a dendrogram showed clades separating by the production of bicyclogermacrene, aromadendrane and 5,10-cycloaromadendrane sesquiterpenoids for the four species. Comparison of volatile metabolite profiles to 13 other Vitex species showed strong similarities in the production of some monoterpenes, but varied by their production of larger terpenes, especially those with gem-dimethylcyclopropyl subunits on seven-member ring compounds. From this work, we suggest that the sesquiterpene skeleton with seven member rings is a good chemosystematic biomarker candidate for the Vitex genus. Separation using this biomarker was then validated using Inter-Simple Sequence Repeat profiling. Lastly, experiments examining the toxicity of these four oils against the coconut mite Aceria guerreronis showed that only the oil of V. gardneriana had strong acaricidal activity, with an LC50 of 0.85 mg/mL, thus demonstrating its potential for use as a natural pesticide.

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“…The Lantana species presented β-caryophyllene in high concentration, with cubebene, elixene, and phellandrene as minor compounds [ 59 ]. The β-caryophyllene is a chemical marker for species belonging to the Lantana genus [ 60 ]. Lantana camara is the most widespread species of this genus.…”

Section: Essential Oils From the Verbenaceae Familymentioning

confidence: 99%

Antimicrobial Activity and Chemical Composition of Essential Oils from Verbenaceae Species Growing in South America

2018

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The Verbenaceae family includes 2600 species grouped into 100 genera with a pantropical distribution. Many of them are important elements of the floras of warm-temperature and tropical regions of America. This family is known in folk medicine, and its species are used as digestive, carminative, antipyretic, antitussive, antiseptic, and healing agents. This review aims to collect information about the essential oils from the most reported species of the Verbenaceae family growing in South America, focusing on their chemical composition, antimicrobial activity, and synergism with commercial antimicrobials. The information gathered comprises the last twenty years of research within the South American region and is summarized taking into consideration the most representative species in terms of their essential oils. These species belong to Aloysia, Lantana, Lippia, Phyla, and Stachytarpheta genera, and the main essential oils they contain are monoterpenes and sesquiterpenes, such as β-caryophyllene, thymol, citral, 1,8-cineole, carvone, and limonene. These compounds have been found to possess antimicrobial activities. The synergism of these essential oils with antibiotics is being studied by several research groups. It constitutes a resource of interest for the potential use of combinations of essential oils and antibiotics in infection treatments.

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Chemical and molecular characterization of fifteen species from the Lantana (Verbenaceae) genus

Cited by 16 publications

References 31 publications

Foliar phenolic compounds of ten wild species of Verbenacea as antioxidants and specific chemomarkers

Foliar phenolic compounds of ten wild species of Verbenacea as antioxidants and specific chemomarkers

Volatile Metabolomic Composition of Vitex Species: Chemodiversity Insights and Acaricidal Activity

Antimicrobial Activity and Chemical Composition of Essential Oils from Verbenaceae Species Growing in South America

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