Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa

Block, Luciana Catia; Santos, Adair Roberto Soares; Souza, Márcia María de; Scheidt, Cristiano; Yunes, Rosendo A.; Santos, M. A. C. Dos; Monachè, Franco Delle; Filho, Valdir Cechinel

doi:10.1016/s0378-8741(98)00019-1

Cited by 64 publications

(36 citation statements)

References 16 publications

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“…identifi ed steroids such as sitosterol ester and stigmasterol, the triterpene lupeol and the diterpene kaurenoic acid (Abreu et al, 2001). The antiinfl ammatory and antinociceptive effects of stigmasterol (Santos et al, 1995;Garcia et al 1999), beta-sitosterol and beta-sitosteryl-beta-D-glucoside (Villaseñor et al, 2002), kaurenoic acid (Block et al, 1998;Paiva et al, 2003) and lupeol, (Fernández et al, 2001a,b;Nikiéma et al, 2001) isolated from different vegetal species have been demonstrated in pharmacological models and may contribute to the effect of MECP.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)

Rocha¹,

Neto-Neves²,

Costa³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: "Avaliação dos efeitos antinociceptivo e antiinfl amatório de Croton pullei var. glabrior Lanj. (Euphorbiaceae)". Croton pullei var. glabrior Lanj. (Euphorbiaceae) é uma liana, amplamente distribuída na Floresta Amazônica. Na medicina popular, diversas plantas do gênero Croton têm sido utilizadas com fi ns terapêuticos em patologias que envolvem dor e infl amação, o que justifi ca este trabalho. O objetivo deste estudo foi investigar as atividades antinociceptiva e antiinfl amatória do extrato metanólico das folhas de C. pullei (MECP). O MECP reduziu, de forma dose-dependente, o número de contorções abdominais (1,2 %) em camundongos, sugerindo uma atividade antinociceptiva da planta. Por outro lado, o MECP não alterou signifi cativamente a reatividade ao estímulo térmico no teste da placa quente e a reatividade à estimulação química na primeira fase do teste da formalina, indicando um mecanismo não-opioidérgico. O MECP reduziu a nocicepção na segunda fase do teste da formalina, inibiu o edema de orelha induzido pelo óleo de croton e reduziu a migração leucocitária no teste da peritonite induzida por carragenina, indicando uma atividade antiinfl amatória. Apesar dos mecanismos responsáveis pelos efeitos da planta ainda não estarem completamente esclarecidos, estes resultados parecem justifi car o uso medicinal potencial de Croton pullei var. glabrior Lanj. em patologias que envolvam dor e infl amação.Unitermos: Antiinfl amatório, antinociceptivo, Croton pullei var. glabrior, fi tomedicina. ABSTRACT:Croton pullei var. glabrior Lanj. (Euphorbiaceae) is a liana, vastly distributed in the Amazonian Forest. In the folk medicine, several plants of the Croton genus have been used with therapeutic purposes in pathologies that involve painful and infl ammatory diseases which justify this work. The aim of this study was to investigate the antinociceptive and antiinfl ammatory activities of the C. pullei leaves methanol extract (MECP). MECP reduced in a dose-dependent manner the number of acetic acid-induced abdominal writhing (1.2%) in mice, suggesting an antinociceptive activity of the plant. On the other hand, MECP did not signifi cantly modify the reactivity to the thermal stimulation in the hot-plate test and the reactivity to the chemical stimulation in the formalin test fi rst phase, indicating a non-opioid mechanism. MECP reduced the formalin-induced nociception in the second phase, inhibited the croton oil-induced ear edema and reduced the leukocytes migration in the test of the carrageenan-induced peritonitis, indicating an antiinfl ammatory activity. Although the mechanisms that underlie these plant effects are not completely elucidated, these results appear to support the potential medicinal use of Croton pullei var. glabrior Lanj. against painful and infl ammatory diseases.

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Section: Discussionmentioning

confidence: 99%

Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)

Rocha¹,

Neto-Neves²,

Costa³

et al. 2008

Rev. bras. farmacogn.

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“…Pharmacological analysis revealed that luteolin caused gradual and significant inhibition of abdominal writhings. When compared to acetylsalicylic acid, acetaminophen, dipyrone and indomethacin, by using the same pharmacological procedure, luteolin was about 8-16-fold more active than these standard drugs (Block et al, 1998). Luteolin was also detected, among other flavonoids, in extract of Vitex rotundifolia fruits (Emi et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported the antinociceptive effects of flavonoids (Thirugnanasambantham et al, 1990;Pathak et al, 1991;Ramesh et al, 1998;Toker et al, 2004), and, of particular interest is that one reporting the antinociceptive activity of luteolin (Block et al, 1998), which was isolated from VD extract. The antinociceptive activity of this flavonoid has been evaluated by Block et al (1998) in the acetic acid-induced abdominal constriction model in mice. Pharmacological analysis revealed that luteolin caused gradual and significant inhibition of abdominal writhings.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts

Leitão¹,

Santos²,

Monachè³

et al. 2011

Rev. bras. farmacogn.

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Abstract:Vitex cymosa Bertero ex Spreng., Lamiaceae, is found in Central and Amazon regions of Brazil, where it is popularly used as antirheumatic. Extracts from the leaves of V. cymosa were tested in analgesia models such as abdominal contortions induced by acetic acid and formalin to test peripheral analgesia; as well as the tail flick and hot plate models, to test spinal and supraspinal analgesia. A significant reduction was observed in the number of contortions with all extracts and in all doses. In the formalin model, a reduction in the second phase (inflammatory) was observed with all extracts, whereas only the n-butanol extract was able to act in the first, neurogenic, phase. In the tail flick model, all extracts increased latency time. Naloxone treatment reverted analgesic effect of all extracts with the exception of the dichloromethane one. All extracts developed peripheral and central analgesic activity. In the hot plate model no antinociceptive effect was observed for all tested extracts. All these results taken together suggest that V. cymosa leaf extracts were able to promote peripheral and central antinociceptive activity mediated by the opioid system.Twenty three substances were isolated and identified in the extracts and include flavonoids (C-glucosyl flavones, flavones and flavonols), triterpene acids from ursane and oleanane types, iridoids (free and glucosides), as well as simple phenols.

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“…In a previous phytochemical study, four flavonoids (jaceidin, jaceidin-7-methyl-ether, luteolin and kaempferol-6-methyl-ether 3-rhamnoglucoside) were isolated from Artemisia copa (Quarenghi et al, 1991). Luteolin and its derivatives have been described to exert several interesting pharmacological activities, namely antitumoral, antioxidant, anti-inflammatory, analgesic (Block et al, 1998;Kotanidou et al, 2002) and anxiolytic (Coleta et al, 2008). Pharmacological studies of the plant revealed that the aqueous extract of aerial parts of A. copa possess analgesic and anti-inflammatory activity (Acevedo et al, 2005).…”

Section: Introductionmentioning

confidence: 99%