Chemical and Physical Properties of Polyimides: Biomedical and Engineering Applications

Georgiev, Anton; Dimov, D; Spassova, E.; Assa, J.; Dineff, P. D.; Danev, G.

doi:10.5772/53918

Cited by 27 publications

(31 citation statements)

References 38 publications

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“…In the past years, another class of polymers emerged as bio-and hemocompatible materials, namely polyimides (PIs) [10]. They have imide rings along the backbone, which confer high thermo-oxidative resistance, enhanced mechanical strength and superior chemical resistance [11]. Despite their promising properties for biomedicine, little has been published regarding PI compatibility with cells/tissues and blood.…”

Section: Introductionmentioning

confidence: 99%

Semi-alicyclic polyimides as potential membrane oxygenators: Rheological implications on film processing, morphology and blood compatibility

Albu¹,

Hulubei²,

Stoica³

et al. 2019

Express Polym. Lett.

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Two polyimide structures were prepared from an alicyclic dianhydride and aromatic diamines, containing or lacking fluorine, and were tested as potential membrane oxygenators. First, the solution rheological properties were investigated to evaluate their effect on film processing by tape casting. Velocity and shear rates profiles were simulated to determine the shearing conditions during tape casting and transfer them in the flow curves. Proper films were obtained at a viscosity corresponding to a concentration in entangled regime, where pseudoplastic behavior is still noticed at shear rates beneath the blade. Theoretical predictions of gas permeability indicated a good oxygen (O 2 ) exchange and carbon dioxide (CO 2 ) removal through the studied polymers. Atomic force microscopy (AFM) scans revealed a morphology characterized by an intrinsic porosity. The pore size, uniformity and size distribution was affected by the structure of the diamine moiety. The interactions of blood with polyimide films indicated no prevalent adhesion of cells or plasma proteins. The results showed that the examined samples have adequate properties for potential membrane oxygenator applications.

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Section: Introductionmentioning

confidence: 99%

Semi-alicyclic polyimides as potential membrane oxygenators: Rheological implications on film processing, morphology and blood compatibility

Albu¹,

Hulubei²,

Stoica³

et al. 2019

Express Polym. Lett.

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“…For this reason, we chose a polyimide insulation material, which has already demonstrated good passivation properties in clean-room fabricated MEA arrays. 86 As we are aiming for a fully printed device, it is crucial to choose a suitable ink and to understand possible factors that could induce passivation failure. One common problem in printing continuous passivation films is dewetting, which is especially important for covering areas that are larger than two printed drops.…”

Section: Resultsmentioning

confidence: 99%

Printed microelectrode arrays on soft materials: from PDMS to hydrogels

et al. 2018

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Microelectrode arrays (MEAs) provide promising opportunities to study electrical signals in neuronal and cardiac cell networks, restore sensory function, or treat disorders of the nervous system. Nevertheless, most of the currently investigated devices rely on silicon or polymer materials, which neither physically mimic nor mechanically match the structure of living tissue, causing inflammatory response or loss of functionality. Here, we present a new method for developing soft MEAs as bioelectronic interfaces. The functional structures are directly deposited on PDMS-, agarose-, and gelatin-based substrates using ink-jet printing as a patterning tool. We demonstrate the versatility of this approach by printing high-resolution carbon MEAs on PDMS and hydrogels. The soft MEAs are used for in vitro extracellular recording of action potentials from cardiomyocyte-like HL-1 cells. Our results represent an important step toward the design of next-generation bioelectronic interfaces in a rapid prototyping approach.npj Flexible Electronics (2018) 2:15 ;

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“…2 b). PI is a biocompatible polymer [22], [23] with good chemical resistance and high glass transition temperature [24], which allows for most standard photolithographic cleanroom processes. The position of the metallization between two layers of PI (Fig.…”

Section: Objectives and Backgroundmentioning

confidence: 99%