Chemical and Structural Biology to Direct the Repurposing of Sulindac

Simard, Jeffrey R.; Rauh, Daniel

doi:10.1002/cmdc.200900384

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Sulindac appears to bind specifically to the PDZ domain of Dvl, a key molecule that relays Wnt signals from initial receptors to various downstream components . The specificity of binding is largely determined by the side chain on arginine residue 322 . Lee et al .…”

Section: Inhibitors Targeting Dvl Proteinmentioning

confidence: 99%

Modulating the wnt signaling pathway with small molecules

Tran¹,

Zheng

2017

Protein Science

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Wnt signaling is a critical component during embryonic development and also plays an important role in regulating adult tissue homeostasis. Abnormal activation of Wnt signaling has been implicated in many cancers, while reduced activity of Wnt signaling leads to poor wound healing and structural formations. Thus, extensive efforts have been focused on developing small molecules that have potential to either inhibit or activate the pathway, hoping these molecules can offer leads for novel approaches in treating different human diseases. Many small-molecule inhibitors specifically target various elements, such as Frizzled, Disheveled, Porcupine, or Tankyrase, within the Wnt signaling pathways. These small molecules not only have the potential to be further developed as therapeutic reagents, but they may also be used as chemical probes to dissect the underlying mechanism of the Wnt signaling pathways. Therefore, their respective mechanisms and effective dosages are highly pertinent. Aiming to provide an overview of those molecules in a concise, easy-to-use manner, we summarize and organize the current research on them so that it may be helpful for utilization in different studies.

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Section: Inhibitors Targeting Dvl Proteinmentioning

confidence: 99%

Modulating the wnt signaling pathway with small molecules

Tran¹,

Zheng

2017

Protein Science

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An Old NSAID Revisited: Crystal Structure of Aldose Reductase in Complex with Sulindac at 1.0 Å Supports a Novel Mechanism for its Anticancer and Antiproliferative Effects

Steuber¹

2011

ChemMedChem

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Old friends in new guise: repositioning of known drugs with structural bioinformatics

Haupt¹,

Schroeder²

2011

Briefings in Bioinformatics

137

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Developing a drug de novo is a laborious and costly endeavor. Thus, the repositioning of already approved drugs for the treatment of new diseases is promising and valuable. One computational approach to repositioning exploits the structural similarity of binding sites of known and new targets. Here, we review computational methods to represent and align binding sites. We review available tools, present success stories and discuss limits of the approach.

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Chemical and Structural Biology to Direct the Repurposing of Sulindac

Cited by 3 publications

References 9 publications

Modulating the wnt signaling pathway with small molecules

Modulating the wnt signaling pathway with small molecules

An Old NSAID Revisited: Crystal Structure of Aldose Reductase in Complex with Sulindac at 1.0 Å Supports a Novel Mechanism for its Anticancer and Antiproliferative Effects

Old friends in new guise: repositioning of known drugs with structural bioinformatics

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