Chemical characterisation and hepatoprotective potential of <i>Cosmos sulphureus</i> Cav. and <i>Cosmos bipinnatus</i> Cav.

Saleem, Mohammad; Ali, Hafiz Akbar; Akhtar, Muhammad Furqan; Saleem, Uzma; Saleem, Ammara; Irshad, Iram

doi:10.1080/14786419.2017.1413557

Cited by 28 publications

(30 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Quantitative analysis of both extracts was carried out by HPLC. The sample for HPLC analysis was prepared according to the previous method for the detection of phenolic and flavonoid compounds (Saleem et al, 2019). In short, reverse phase HPLC with an LC‐10‐AT pump was used for the detection.…”

Section: Methodsmentioning

confidence: 99%

Chemical characterization, antioxidant evaluation, and antidiabetic potential of Pinus gerardiana (Pine nuts) extracts

et al. 2020

Self Cite

View full text Add to dashboard Cite

Methanolic and ethyl acetate extracts of pine nuts were evaluated for in vitro antioxidant and inhibition of alpha‐amylase activities. Pine nut extracts were orally administered to alloxan monohydrate‐induced diabetes in mice at 250, 500, and 750 mg/kg. Both extracts showed a significant antioxidant and inhibition of alpha‐amylase activities. Animal studies showed a decline in fasting blood glucose, hyperlipidemia, and weight loss in diabetic mice. The administration of plant extracts decreased the blood glucose level during the oral glucose tolerance test. Histopathological examination showed a decrease in alloxan‐induced lesions in the pancreas, liver, and kidney of animals treated with pine nut extracts. Furthermore, pine nut extract ameliorated oxidative stress‐induced hepatotoxicity in diabetic mice. The presence of quercetin, gallic acid, vanillic acid, benzoic acid, syringic acid, m‐coumaric acid, and other phenolic compounds might be related to hypoglycemic, alpha‐amylase inhibitory, antioxidant, and antihyperlipidemic potential of pine nut extracts. Practical applications Dry fruits are rich in dietary nutrients, minerals, and phytochemicals that can be used to treat and prevent lifestyle disease. Pine nuts are edible and have economic importance in addition to several traditional uses such as diuretic, antiseptic, expectorant, antibacterial, antiviral, antifungal, antihypertensive, and antineuralgic properties. This study was conducted to investigate the pine nut extracts for their antioxidant and antidiabetic potentials using in vitro methods and animal disease model. The findings of the present study suggest that the extracts of Pine nuts may be helpful in treating hyperglycemia during diabetes and prevent its complications such as hepatic damage, nephrotoxicity, weight loss, and hyperlipidemia.

show abstract

Section: Methodsmentioning

confidence: 99%

Chemical characterization, antioxidant evaluation, and antidiabetic potential of Pinus gerardiana (Pine nuts) extracts

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Helium gas was used for collision. The flow rate of the sample was 0.3 mL/min [8,9]. Mobile phases comprised of 2% acetic acid (A) and acetonitrile (B) with a gradient program: 5% (10 min), 10% (1 min), 40% (9 min), 20% (10 min), 40% (10 min) and 100% acetonitrile until the completion of the run.…”

Section: Methodsmentioning

confidence: 99%

“…Mobile phases comprised of 2% acetic acid (A) and acetonitrile (B) with a gradient program: 5% (10 min), 10% (1 min), 40% (9 min), 20% (10 min), 40% (10 min) and 100% acetonitrile until the completion of the run. Collision induced spectra was obtained in the range of 1.2–1.7 V fragmentation amplitude [8]. Phytochemicals were identified from the NIST library while comparing their mass spectra and retention times.…”

Section: Methodsmentioning

confidence: 99%

Antidiabetic Potential of Mangifera indica L. cv. Anwar Ratol Leaves: Medicinal Application of Food Wastes

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background and objectives: Anwar Ratol is one of the most famous cultivar of mango in South Asia, especially Pakistan. Mango leaves are left as food waste. This study evaluated the potential of mango (Anwar Ratol) leaves for their use against diabetes mellitus. Material and Methods: In this study, hydro-alcoholic extract of the plant leaves was prepared and evaluated by electrospray ionization mass spectroscopy (ESI-MS) and high-performance liquid chromatography (HPLC) for the presence of phytochemicals. The plant extract was administered to Alloxan induced diabetic mice followed by evaluation through oral glucose tolerance test; determination of postprandial glucose, body weight, lipid profile and histopathological evaluation of pancreas. Results: Chemical evaluation revealed the presence of mangiferin, rhamnetin, catechin, epicatechin, iriflophenone 3-C-β-D-glucoside, gallic acid and other phenolic and flavonoid compounds. The plant extract exhibited a decrease in postprandial blood glucose following seven days therapy in diabetic mice. The extract also prevented the rise in blood glucose level as determined by glucose tolerance test in diabetic mice. Furthermore, therapy of diabetic mice with the extract prevented a decrease in body weight and decline in beta-cell mass associated with alloxan and improved lipid profile. Conclusion: The findings of the study clearly suggested that the leaf extract of the plant might possess anti-diabetic activity possibly due to the presence of mangiferin and other phytochemicals such as phenolic and flavonoid compounds. This study will serve as a basis for the use of mango leaf extract against diabetes. Furthermore, this study will also provide basis for the bioassay-based fractionation and isolation of active principles responsible for the antidiabetic potential of mango leaves.

show abstract

“…Lantana camara L. is used in medicine against influenza, measles, stomachache, chicken pox, fever, rheumatisms, asthma, and hypertension (Kumar et al, 2015). In addition, the major functional molecules of three plants extract include alkaloids, carbohydrates, proteins, flavonoids, terpenoids, steroids, saponins, and tannins (Ghisalberti, 2000;Wang et al, 2007;Saleem et al, 2019) as capping and stabilizing agents play a significant role for the synthesis of nanoparticles (Duan et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Phytofabrication of Silver Nanoparticles Using Three Flower Extracts and Their Antibacterial Activities Against Pathogen Ralstonia solanacearum Strain YY06 of Bacterial Wilt

2020

View full text Add to dashboard Cite

Bacterial wilt caused by the phytopathogen Ralstonia solanacearum (R. solanacearum) is a devastating plant disease worldwide. The use of bactericides and antibiotics for controlling bacterial wilt has shown low efficiency and posed environmental risks. This study was to phytofabricate silver nanoparticles (AgNPs) mediated by canna lily flower (Canna indica L.), Cosmos flower (Cosmos bipinnata Cav.), and Lantana flower (Lantana camara L.). The biosynthesized AgNPs were confirmed and characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscope (TEM), and scanning electron microscopy (SEM). UV-visible spectra showed absorption peak bands at 448, 440, and 428 nm of AgNPs synthesized by C. indica L., C. bipinnata Cav., and L. camara L. flowers, respectively. FTIR spectra confirmed that biofunctional groups of flower extract were involved in the synthesis of AgNPs as capping and stabilizing agents. The spherical AgNPs synthesized by C. indica L., C. bipinnata Cav., and L. camara L. flowers had average diameters of 43.1, 36.1, and 24.5 nm, respectively. The AgNPs (10.0 μg/ml) synthesized by L. camara L. flower had a maximum suppression zone of 18 mm against R. solanacearum strain YY06 compared with AgNPs synthesized by C. indica L. and C. bipinnata Cav. flowers. Bacterial growth, biofilm formation, swimming motility, efflux of nucleic acid, cell death, cell membrane damage, and reactive oxygen species (ROS) generation of R. solanacearum were also negatively affected by AgNPs with high concentration and small size. In summary, the biosynthesized AgNPs can be used as an efficient and environmentally friendly antibacterial agent to reasonably inhibit R. solanacearum.

show abstract

Chemical characterisation and hepatoprotective potential of Cosmos sulphureus Cav. and Cosmos bipinnatus Cav.

Cited by 28 publications

References 10 publications

Chemical characterization, antioxidant evaluation, and antidiabetic potential of Pinus gerardiana (Pine nuts) extracts

Chemical characterization, antioxidant evaluation, and antidiabetic potential of Pinus gerardiana (Pine nuts) extracts

Antidiabetic Potential of Mangifera indica L. cv. Anwar Ratol Leaves: Medicinal Application of Food Wastes

Phytofabrication of Silver Nanoparticles Using Three Flower Extracts and Their Antibacterial Activities Against Pathogen Ralstonia solanacearum Strain YY06 of Bacterial Wilt

Contact Info

Product

Resources

About