Chemical characterization and biological activity of essential oils from Daucus carota L. subsp. carota growing wild on the Mediterranean coast and on the Atlantic coast

Maxia, Andrea; Piras, Alessandra; Porcedda, Silvia; Tuveri, Enrica; Gonçalves, María José; Cavaleiro, Carlos; Salgueiro, Lı́gia

doi:10.1016/j.fitote.2008.09.008

Cited by 92 publications

(54 citation statements)

References 9 publications

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“…The major sesquiterpene in F2 (61.4%) was identified as 2-himachalen-6-ol by GCMS (NIST Library 2011, 96% match). According to the available literature (Gonny et al, 2004;Maxia et al, 2009;Mockute & Nivinskiene, 2004;Rossi et al, 2007;Staniszewska et al, 2005), and to the best of our knowledge, this is the first time of reporting the presence of 2-himachalen-6-ol in wild carrot species. This sesquiterpene was first isolated from the heartwood of Juniperus chinensis Linn.…”

Section: Discussionmentioning

confidence: 75%

“…Additionally, the sesquiterpenes b-caryophyllene (17%; F1) and a-humelene (28%; F1) present in the native Lebanese Daucus carota were either detected in trace amounts or not found in DC species worldwide. On the contrary, a-longipinene and b-himachalene appear to be limited to the Lebanese and Italian wild carrot (Gonny et al, 2004;Maxia et al, 2009;Mockute & Nivinskiene, 2004;Rossi et al, 2007;Staniszewska et al, 2005). These findings stress the importance of the geographical location on the chemical composition of the plant.…”

Section: Discussionmentioning

confidence: 79%

“…In Lebanon, people eat its young taproot cooked and use the plant in folk medicine for the treatment of cancer, gastric ulcer, diabetes, muscle pain, and to protect against hepatic diseases. Available literature on the therapeutic effects of wild carrot showed that the plant possesses antilithic, diuretic (Thomas et al, 2001;Wyk & Wink, 2004) antibacterial, and antifungal activities (Maxia et al, 2009;Rossi et al, 2007;Staniszewska et al, 2005). The oil extract of wild carrot has been shown to consist mainly of phenols, flavonoids, monoterpenes, sesquiterpenes, and phenylpropanoids (Gonny et al, 2004;Maxia et al, 2009;Mockute & Nivinskiene, 2004;Shebaby et al, 2013;Staniszewska et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carotassp.carota)

Shebaby

Daher

El‐Sibai

et al. 2015

Pharmaceutical Biology

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Context: Wild carrot, Daucus carota L. ssp. carota (Apiacae), is widely distributed throughout the world and has various uses in traditional medicine in Lebanon.Objective: The present study aimed to fractionate and analyze the chemical composition of the Daucus carota oil extract (DCOE) fractions and to evaluate their antioxidant and hepatoprotective properties in vitro and in vivo. Materials and methods: DCOE was chromatographed on silica gel column to produce four fractions: pentane (F1), 50:50 pentane:diethyl ether (F2), diethyl ether (F3), and 93:7 chloroform: methanol (F4). Qualitative and quantitative analyses of oil fractions were performed by GC-MS and HPLC techniques. The in vitro antioxidant properties were assessed using DPPH, FIC, and ferric-reducing antioxidant power (FRAP) assays. The hepatoprotective property was determined by examining the levels of serum markers (alanine transaminase (ALT) and aspartate transaminase (AST)) and hepatic antioxidant (superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST)) enzymes in CCl 4 -intoxicated mice pretreated with intraperitoenal 50, 100, or 200 mg/kg b.w. of the oil fractions for 5 d. Results: GCMS analysis of F2 revealed the presence of 2-himachalen-6-ol (61.4%) which is reported for the first time in Daucus carota species. F3 and F4 were rich in phenolics and flavonoids and demonstrated significant DPPH activity (IC 50 ¼ 0.29 and 0.38 mg/ml, respectively) and high FRAP values (225.11 and 437.59 mmol FeSO 4 /g, respectively). The sesquiterpene-rich fraction F1 had the highest FIC ability (IC 50 ¼ 0.28 mg/ml). Pretreatment with F1 and F4 reversed the CCl 4 -induced decrease in SOD, CAT, and GST levels and reduced significantly hepatic damage. Discussion and conclusion: The current results suggested that wild carrot oil fractions exhibited a unique chemical composition and possessed significant antioxidant activities as well as hepatoprotective effects against CCl 4 -induced hepatotoxicity.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carotassp.carota)

Shebaby

Daher

El‐Sibai

et al. 2015

Pharmaceutical Biology

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“…[7,12,13] The parts of the plant, its stage of development, and geographical origin can significantly influence the composition of the oils obtained from the species. [14,15] The control of plant disease is a considerable problem in agriculture practice. Plant pathogens include fungi and bacteria and can cause diseases or damages in plants, also being responsible for significant losses of crop production.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antibacterial and antifungal activities of seed essential oil of Ferulago angulata

Moghaddam

Mehdizadeh

Najafgholi

et al. 2018

International Journal of Food Properties

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The aim of this study was to determine the chemical composition and the in vitro antimicrobial effects of seed essential oil of Ferulago angulata. The oil analyses by GC and GC/MS resulted in the identification of 39 compounds representing 91.07% of the oil. The major constituents were (Z)-β-ocimene (19.93%), α-pinene (15.50%), p-cymene (7.67%), sabinene (7.49%), β-phellandrene (5.5%), and α-phellandrene (4.95%). The oil was also screened for its antimicrobial properties against six bacteria (Erwinia amylovora, Xanthomonas oryzae, Pseudomonas syringae, Pectobacterium carotovorum, Ralstonia solanacearum, Bacillus thuringiensis) and six fungi (Alternaria alternata, Culvularia fallax, Macrophomina phaseolina, Fusarium oxysporum, Cytospora sacchari, Colletotrichum tricbellum). According to the results of antibacterial activity, B. thuringiensis (with 8 µL mL −1 minimal inhibitory concentration (MIC) and 15 µL mL −1 minimum bactericidal concentration (MBC)) was the most sensitive bacterium; P. carotovorum and R. solanacearum (with 20 µL mL −1 MIC and 30< MBC) were the most resistant bacteria. Additionally, a broad differentiation against all of the tested fungi showed that the most susceptible and resistant fungi after 6 days at the highest concentration (800 µL L −1 ) were F. oxysporum (100.0 ± 0.00%) and C. tricbellum (52.50 ± 1.67%) of growth inhibition, respectively. ARTICLE HISTORY

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“…The plant volatile oil was also used in the European folk medicine as an effective urinary antiseptic and anti-inflammatory drug for cystitis and prostatitis [9]. Also, it has been reported to possess antilithic, diuretic [10,11], antibacterial and antifungal activities [12,13,14]. Recent studies conducted in our laboratories showed that D. carota (DC) oil extract exhibited anti-inflammatory, antiulcer [15], antioxidant [16] and anticancer activities [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

<b><i>Daucus carota</i></b> Pentane/Diethyl Ether Fraction Inhibits Motility and Reduces Invasion of Cancer Cells

Zgheib

Daher²,

Mroueh³

et al. 2014

Chemotherapy

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Daucus carota (DC) is a herb used in folklore medicine in Lebanon to treat numerous diseases including cancer. Recent studies in our laboratory on DC oil and its fractions revealed potent anticancer activities in vitro and in vivo. The present study aims to investigate the effect of the most potent DC fraction, pentane/diethyl ether (50:50), on lung, skin, breast and glioblastoma cancer cell motility and invasion. Upon treatment, a pronounced decrease in cancer cell motility was observed in the 4 cell lines. The treatment also led to a decrease in cancer cell invasion and an increased cell adhesion. Additionally, the DC fraction caused a decrease in the activation of the ρ-GTPases Rac and CDC42, a finding that may partially explain the treatment-induced decrease in cell motility. The current study demonstrates a crucial effect of the DC pentane/diethyl ether fraction on cancer cell motility and metastasis, making it a potential candidate for cancer therapy specifically targeting cancer motility and metastasis.

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Chemical characterization and biological activity of essential oils from Daucus carota L. subsp. carota growing wild on the Mediterranean coast and on the Atlantic coast

Cited by 92 publications

References 9 publications

Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carotassp.carota)

Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carotassp.carota)

Chemical composition, antibacterial and antifungal activities of seed essential oil of Ferulago angulata

<b><i>Daucus carota</i></b> Pentane/Diethyl Ether Fraction Inhibits Motility and Reduces Invasion of Cancer Cells

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