Chemical characterization and cytotoxic, genotoxic, and mutagenic properties of Baccharis trinervis (Lam, Persoon) from Colombia and Brazil

Jaramillo-Garcia, Victoria P.; Trindade, Cristiano; Lima, Elisiane; Guecheva, Temenouga Nikolova; Villela, Izabel Vianna; Martínez‐López, Wilner; Corrêa, Dione Silva; Ferraz, Alexandre de Barros Falcão; Moura, Sidnei; Quintana-Sosa, Milton; Silva, Juliana da; Henriques, João Antônio Pêgas

doi:10.1016/j.jep.2017.10.027

Cited by 21 publications

(10 citation statements)

References 65 publications

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“…The risk-benefit ratio of any drug substance is an influential criterion for the recommendation as a therapy in human diseases (Jaramillo-García et al, 2018). In the present study, methanolic extract of (Capello, Fischer, & Hungerbühler, 2007).…”

Section: Discussionmentioning

confidence: 89%

“…The results of cytotoxicity assay are in concordance to the results of other species of this genus such as M. oleifera leaf callus, and stem bark extracts on HeLa cell line(Jafarain, Asghari, & Ghassami, 2014;Kumbhare, Guleha, & Sivakumar, 2012;Nair & Varalakshmi, 2011). The cytotoxic potential of the plant might be due to its phenols, flavonoids, alkaloids as reported earlier(Jaramillo-García et al, 2018;Özçelik, Kartal, & Orhan, 2011;…”

mentioning

confidence: 71%

“…These are a robust source of novel drug development. The risk‐benefit ratio of any drug substance is an influential criterion for the recommendation as a therapy in human diseases (Jaramillo‐García et al., 2018). In the present study, methanolic extract of M. oleifera leaves was evaluated at acute and subchronic (90 days repeated dose) levels in Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

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HPLC analysis, cytotoxicity, and safety study ofMoringa oleiferaLam. (wild type) leaf extract

Saleem

Akhtar

et al. 2020

J. Food Biochem.

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The study was planned to evaluate toxicity of M. oleifera leaf methanol extract in Wistar rats, cytotoxic potential and chemically characterize it. Acute toxicity study revealed no mortality at 2,000 mg/kg dose. In subchronic toxicity, 150, 300, and 600 mg/kg extract were administered in both sexes for 90 days. A decrease in body weight, cholesterol, and low-density lipoproteins, as well as an increase in the platelet count were observed. The histology of heart, lung, and kidney was normal. The oxidative stress biomarkers were normal in the liver tissue. In vitro cytotoxicity assay revealed that IC50 of the plant extract was more than 1,000 µg/ml. FTIR explored various functional groups and HPLC analysis indicated the presence of kaempferol and quercetin in the plant extract. These results showed that the plant extract might be safe up to 2,000 mg/kg single dose. The long term use of the plant extract was mostly devoid of major system toxicities. Practical applications M. oleifera is a multipurpose tree. It is a cruciferous plant that has nutritional as well as medicinal properties. It is exhibited a multitude of nutraceutical or pharmacological properties such as anti-inflammatory, lipid-lowering, anticancer, hypoglycemic, and antihypertensive activities. It is widely used by local inhabitants for their health, food, agriculture, and cosmetic purposes. Among other plant parts, its leaves are mostly used as a functional food because of abundant proteins, β-carotene, polyphenol, vitamin C, and vitamin E. The current study was designed to validate its safety in acute and long term use. The data of this study suggested that the plant can be safely used as a nutraceutical as well as a nutritional food.

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Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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HPLC analysis, cytotoxicity, and safety study ofMoringa oleiferaLam. (wild type) leaf extract

Saleem

Akhtar

et al. 2020

J. Food Biochem.

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“…Antimicrobial and antiviral: several in vitro studies showed moderate activity of aqueous extracts of the aerial parts and the essential oil against pathogenic bacteria and fungi as well as against Herpes simplex and HI Virus strains, as reviewed (Jaramillo-Garcıá et al, 2018).…”

Section: Safe and Effective D31mentioning

confidence: 99%

“…Cytotoxic and genotoxic effects of aqueous extract of the aerial parts and different organic solvent fractions were reported in different assays (Jaramillo-Garcıá et al, 2018). Antidiabetic: a number of in vitro and in vivo studies reported significant effects (incl.…”

Section: Safe and Effective D31mentioning

confidence: 99%

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

et al. 2020

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The quality of health care in Mesoamerica is influenced by its rich cultural diversity and characterized by social inequalities. Especially indigenous and rural communities confront diverse barriers to accessing formal health services, leading to often conflicting plurimedical systems. Fostering integrative medicine is a fundamental pillar for achieving universal health coverage (UHC) for marginalized populations. Recent developments toward health sovereignty in the region are concerned with assessing the role of traditional medicines, and particularly herbal medicines, to foster accessible and culturally pertinent healthcare provision models. In Mesoamerica, as in most regions of the world, a wealth of information on traditional and complementary medicine has been recorded. Yet these data are often scattered, making it difficult for policy makers to regulate and integrate traditionally used botanical products into primary health care. This critical review is based on a quantitative analysis of 28 survey papers focusing on the traditional use of botanical drugs in Mesoamerica used for the compilation of the "Mesoamerican Medicinal Plant Database" (MAMPDB), which includes a total of 12,537 use-records for 2188 plant taxa. Our approach presents a fundamental step toward UHC by presenting a pharmacological and toxicological review of the cross-culturally salient plant taxa and associated botanical drugs used in traditional medicine in Mesoamerica. Especially for native herbal drugs, data about safety and effectiveness are limited. Commonly used cross-culturally salient botanical drugs, which are considered safe but for which data on effectiveness is lacking constitute ideal candidates for treatment outcome studies.

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Selective cytotoxicity of ent‐kaurene diterpenoids isolated from Baccharis lateralis and Baccharis retusa (Asteraceae)

Silva

Oliveira

Santos

et al. 2022

Archiv der Pharmazie

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This study presents the cytotoxic activity evaluation of the natural diterpenes ent-kaurenoic acid (1) and its 15β-hydroxy (2), 15β-senecioyloxy (3), and 15βtiglinoyloxy (4) derivatives, isolated from Brazilian native plants, Baccharis retusa and B. lateralis (Asteraceae). Using the MTT (3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) colorimetric assay, it was observed that compound 1 displayed in vitro activity towards the aggressive MDA-MB-231 adenocarcinoma cell line and reduced toxicity against MCF-10A nontumorigenic epithelial cells, indicating expressive selectivity. On the contrary, compounds 2-4 exhibited reduced toxicity and selectivity in both tested cell lines. Based on the chemical structures of compounds 1-4, it is suggested that the presence of additional functional groups at the C-15 position-a hydroxyl group in compound 2 and isomeric isoprene units in compounds 3 and 4-might be responsible for the reduction in the potential/ selectivity. In silico studies show, for compounds 1-4, good predictions regarding bioavailability and ADME (absorption, distribution, metabolism, and excretion) properties as well as no alerts for PAINS (pan-assay structures interference).In conclusion, ent-kaurenoic acid (1), a common diterpenoid isolated in high amounts from different plants belonging to the Baccharis genus, has been shown to be a promising cytotoxic agent against an aggressive adenocarcinoma cell line (MDA-MB-23) and, if well exploited, could be used as a scaffold in the development of molecular prototypes for the treatment of breast cancer.

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Chemical characterization and cytotoxic, genotoxic, and mutagenic properties of Baccharis trinervis (Lam, Persoon) from Colombia and Brazil

Cited by 21 publications

References 65 publications

HPLC analysis, cytotoxicity, and safety study ofMoringa oleiferaLam. (wild type) leaf extract

HPLC analysis, cytotoxicity, and safety study ofMoringa oleiferaLam. (wild type) leaf extract

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

Selective cytotoxicity of ent‐kaurene diterpenoids isolated from Baccharis lateralis and Baccharis retusa (Asteraceae)

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