Chemical characterization and DPP-IV inhibitory activity evaluation of tripeptides from Gynura divaricata (L.) DC.

Natural products from plants targeting key enzymes for the future development of antidiabetic agents

“…The fragmentation patterns associated with molecular networking allowed complete identication, and docking analysis of these peptides revealed their potential DPP-IV inhibitory activity. 95 The IPI fragment is also present in the primary sequence of several peptides obtained from the hydrolysis of food proteins (amaranth, soybean, wheat, maize, and rice). 91 Amaranth is relevant for Latin American countries, where it has been a traditional food in some pre-Columbian (186) 124.0 (1R,2S)-(−)-N-Methylephedrine (187) 27 850.0 (1S,2R)-(+)-Norephedrine (188) 132.0 (1S,2S)-(+)-Pseudoephedrine (189) 4974.0 (1S,2S)-(+)-N-Methylpseudoephedrine (190) 28 890.0 Berberine (191) 16.…”

Hypoglycemic Effects of Gynura divaricata (L.) DC Polysaccharide and Action Mechanisms via Modulation of Gut Microbiota in Diabetic Mice

“…11 It is a popular vegetable with high nutritional value and was approved as a new food source by the Ministry of Health of China in 2010. 12 GD powder can activate insulin signals and improve antioxidant capacity, thereby lowering blood glucose in T2DM mice. 13 At present, studies on the active components of GD mainly focus on small molecules, including flavonoids, alkaloids, terpenes, fatty acids, sterols, etc.…”

“…Gynura divaricata (L.) DC (GD) is a herb widely cultivated in China and Thailand, , which has multiple functions, including hypoglycemic and insulin-sensitizing effects . It is a popular vegetable with high nutritional value and was approved as a new food source by the Ministry of Health of China in 2010 . GD powder can activate insulin signals and improve antioxidant capacity, thereby lowering blood glucose in T2DM mice .…”