Chemical characterization, antioxidant, immune-regulating and anticancer activities of a novel bioactive polysaccharide from Chenopodium quinoa seeds

Hu, Yichen; Zhang, Jinming; Zou, Liang; Fu, Chaomei; Li, Peng; Zhao, Gang

doi:10.1016/j.ijbiomac.2017.03.019

Cited by 148 publications

(92 citation statements)

References 42 publications

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“…Excessive free radicals can induce inflammatory, which is also an important part of carcinogenesis (Hu et al., 2017). Therefore, antioxidants and anti‐inflammatory agents would contribute to the treatment of cancer.…”

Section: Resultsmentioning

confidence: 99%

“…The NO release in RAW 264.7 cells induced by phenolic extracts was determined by Griess reagent (Hu et al., 2017). In brief, RAW 246.7 cells were seeded in 96‐well plates (1.5 × 10 5 cells/well) and treated by several concentrations of phenolic extracts.…”

Section: Methodsmentioning

confidence: 99%

“…The human breast cancer (MCF‐7) cell was used to analyze the antitumor effect of phenolic extracts with MTT assay (Hu et al., 2017). The MCF‐7 cells were seeded at a density of 1 × 10 5 cells per well and cultured with phenolic extracts for 48 hr in a humidified incubator with 5% CO 2 at 37°C.…”

Section: Methodsmentioning

confidence: 99%

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Antioxidant, anti‐inflammatory, and antitumor activities of phenolic compounds from white, red, and black Chenopodium quinoa seed

et al. 2020

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Background and objectives: Quinoa (Chenopodium quinoa Willd.) is a promising nutritious cereal known for its rich nutrition and diverse physiological activities.In order to further investigate the profiles and physiological activities of phenolic compounds from quinoa, the composition of free and bound phenolic extracts from white, red, and black quinoa were analyzed, as well as their antioxidant, anti-inflammatory, and antitumor activities. Findings: Total phenolic content (TPC) and total flavonoid content (TFC) ranged from 514.03 to 1,409.54 mg gallic acid equivalent (GAE)/100g and 177.49 to 407.75 mg rutin equivalent (RE)/100 g, respectively. TPC existed mainly in bound form in red and black quinoa, but free form in white quinoa. Eight individual phenolic acids were detected, with the total acids amount ranging from 86.21 to 188.76 µg/g. Protocatechuic acid was the dominant phenolic acid both in red and black quinoa.Red quinoa showed the highest TPC and TFC, while black quinoa had the highest phenolic acids concentration. Red quinoa also showed the best ABTS and DPPH radical scavenging activities. Positive correlations were found among antioxidant activity and phenolic components. Besides, phenolics from red and black quinoa showed better anti-inflammatory and antitumor activity by down-regulating the NO production and inhibiting the proliferation of MCF-7 cells. Conclusions: Quinoa seed is rich in phenolic components, especially the red and black one. Higher phenolic contents in red and black quinoa can be responsible for their superior antioxidant, anti-inflammatory, and antitumor activities. With potential health benefits, quinoa phenolics may be used as ingredients for functional food. Significance and novelty: Findings of this study revealed useful information on phenolics and bioactivity of quinoa for its cultivation and breeding with functional oriented purpose. The results could be also applied in health food industry for quinoa material selection and processing. K E Y W O R D Santi-inflammatory, antioxidant, antitumor, phenolic compounds, quinoa 704 |

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Antioxidant, anti‐inflammatory, and antitumor activities of phenolic compounds from white, red, and black Chenopodium quinoa seed

et al. 2020

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“…The nutritional values of quinoa are the result of high content of minerals, vitamins, proteins, and essential amino acids, high‐quality fatty acids, antioxidants, and other important multiple bioactive compounds (Vilcacundo & Hernández‐Ledesma, 2017). In addition to excellent nutritive characteristics, quinoa is defined as a “natural functional food” because its antioxidant and anti‐inflammatory compounds provide a beneficial effect for human health and prevent the risks of different various serious diseases, including cancer and cardiovascular diseases, and they also provide a hypocholesterolemic effect (Hu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…This approach is of special interest because colorectal cancer is one of the most common types which affects both women and men (Jemal et al, 2011). Although there is limited literature on the cytotoxic activity of quinoa, recent results have shown that the extracts from quinoa leaves or seeds can have a cytotoxic effect on the cells of various types of cancer in humans, including prostate cancer (Gawlik‐Dziki et al, 2013) and liver, breast (Hu et al, 2017), and cervical carcinoma (Paśko et al, 2019). Therefore, it is expected that the results from the present study will further contribute to the knowledge about the health‐promoting role of quinoa seeds as well as facilitate the selection of suitable quinoa cultivars for growing in the area of Southeast Europe.…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars

et al. 2020

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Background and objectives Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health‐promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time‐dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT‐116, as well as the presence of 7 new phenolic and flavonoid compounds.

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Syed³

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Whole Grains and Their Bioactives

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Chemical characterization, antioxidant, immune-regulating and anticancer activities of a novel bioactive polysaccharide from Chenopodium quinoa seeds

Cited by 148 publications

References 42 publications

Antioxidant, anti‐inflammatory, and antitumor activities of phenolic compounds from white, red, and black Chenopodium quinoa seed

Antioxidant, anti‐inflammatory, and antitumor activities of phenolic compounds from white, red, and black Chenopodium quinoa seed

Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars

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