Chemical characterization of extracts of leaves of Kadsua coccinea (Lem.) A.C. Sm. by UHPLC-Q-Exactive Orbitrap Mass spectrometry and assessment of their antioxidant and anti-inflammatory activities

Shi, Silin; Li, Kailin; Peng, J.; Li, Jian; Luo, Lilan; Liu, Mingjuan; Chen, Yuqi; Xiang, Ziye; Xiong, Pei; Liu, Lianghong; Cai, Wei

doi:10.1016/j.biopha.2022.112828

Cited by 24 publications

(4 citation statements)

References 22 publications

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“…Thus, they were tentatively identified as seneciphylline isomers. Similarly, 9-O-angelylretronecine(87), 7-angeloylretronecine(77), 7-angeloylretronecine N-oxide(16, 32), creatonotine(73), seneciphylline(96, 97, 111), Senecionine(135), Riddelline(60), Integerrimine N-oxide(58), Jacobine(81), usaramine(93), retrorsine(95), bisline(99, 101, 104), riddelline N-oxide(38), retrorsine N-oxide(35), jacoline(20, 98), and jaconine(66) were identified [ [16] , [17] , [18] , [19] , [20] , [21] , [22] ]. Conversely, compounds 106, 27, 121, and 124 showed the quasi-molecular ion at m / z 240.1594 (0.41 ppm, C 13 H 21 NO 3 ), 254.1386 (0 ppm, C 13 H 19 NO 4 ), 338.1961 (0.73 ppm, C 18 H 27 NO 5 ), and 338.1961 (1.09 ppm, C 18 H 27 NO 5 ), respectively, and generated the fragment ions at m / z 122.09 and 140.10, which were the diagnostic ions for platynecine-type pyrrolizidine alkaloids.…”

Section: Resultsmentioning

confidence: 99%

“…Compounds 18, 21, 30, 47, 56, 71, 80, 110, 120, 150, and 161 were tentatively identified as tetrahydro-jacaranone acid, tetrahydroxyxanthone, 2-(3,4-dihydroxyphenyl)ethyl alcoho, cannabiside C, esculin hydrate, coumaroylhexos [ 23 ], esculetin [ 13 ], (E,4R)-4-hydroxy-4,5,5-trimethyl-3-(3-oxobut-1-enyl)cyclohex-2-enone, Nor-seco-glutinosone, mairetolide F or its isomers. and procyanidin, respectively [ 17 ]. Compounds 1, 2, 9, 118, and 159 were identified as mannitol, lactose, uridine, cantharidin, and rubiadin, respectively, by comparing them with the databases.…”

Section: Resultsmentioning

confidence: 99%

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Rapid chemical characterization and pharmacological mechanism of Fining Granules in the treatment of chronic bronchitis based on UHPLC–Q-exactive orbitrap mass spectrometer and network pharmacology

Li,

Chen,

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Rapid chemical characterization and pharmacological mechanism of Fining Granules in the treatment of chronic bronchitis based on UHPLC–Q-exactive orbitrap mass spectrometer and network pharmacology

Li,

Chen,

et al. 2024

Heliyon

Self Cite

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“…T A B L E 3 Identification of chemical composition of A. absinthium. (10), 443 (10), 393 (10), 383 (50), 353 (80), 297 (60), 283 (10), 244 (10), 202 (10), 159 (10), 117 (10) Apigenin (isochlorogenic acid A), P6 (isochlorogenic acid C), and P7 (tricaffeoylquinic acid) were found to be significantly higher than the other common peaks. However, these relative peak areas varied in each sample.…”

Section: Methods Validation and Uplc Fingerprint Analysismentioning

confidence: 99%

Exploring anti‐inflammatory and antioxidant‐related quality markers of Artemisia absinthium L. based on spectrum–effect relationship

Wubuli,

Abdulla,

Zhao

et al. 2024

Phytochemical Analysis

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IntroductionArtemisia absinthium L. is a well‐known medicinal, aromatic, and edible plant with important medicinal and economic properties and a long history of use in treating liver inflammation and other diseases; however, there has been insufficient progress in quality control.ObjectiveThis study aimed to investigate the quality markers for the anti‐inflammatory and antioxidant activities of A. absinthium based on spectrum–effect relationship analysis.Materials and methodsEighteen batches of A. absinthium from different origins were used. Chemical fingerprints were obtained by ultra‐performance liquid chromatography (UPLC). The chemical compositions were identified by quadrupole‐Orbitrap high‐resolution mass spectrometry. Anti‐inflammatory activity was assessed by inhibition of cyclooxygenase‐2 and 15‐lipoxygenase in vitro and inhibition of nitric oxide release in lipopolysaccharide‐induced BV‐2 cells. Antioxidant activity was assessed by DPPH and ABTS radical scavenging assays. The relationship between bioactivity and chemical fingerprints was then analyzed using chemometrics including gray relational analysis, bivariate correlation analysis, and orthogonal partial least squares analysis.ResultsDifferent batches of A. absinthium extracts possessed significant anti‐inflammatory and antioxidant activities to varying degrees. Eighty compounds were identified from A. absinthium, and 12 main common peaks were obtained from the UPLC fingerprints. P3 (chlorogenic acid), P5 (isochlorogenic acid A), and P6 (isochlorogenic acid C) were screened as the most promising active compounds by correlation analysis and further validated for their remarkable anti‐inflammatory effects.ConclusionThis is the first study to screen the quality markers of A. absinthium by establishing the spectrum–effect relationship, which can provide a reference for the development of quality standards and further research on A. absinthium.

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“…Compound 27 (T R = 29.63 min) showed a molecular ion at m/z 425 and was identified as abscisic acid hexoside. The MS 2 mode generated fragment ions at m/z 407 [(M − H)-18] (dehydration), m/z 353 [(M − H)-54] (loss of C 3 H 2 O) and a major m/z 219 [(M − H)-90] (loss of a sugar moiety) [31].…”

Section: Lc-ms-msmentioning

confidence: 99%

Effect of the Harvest Season of Anthyllis henoniana Stems on Antioxidant and Antimicrobial Activities: Phytochemical Profiling of Their Ethyl Acetate Extracts

et al. 2023

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Anthyllis henoniana stems were harvested in two seasons: winter and spring (February and May 2021). In this study, we investigated the antioxidant (DPPH, ABTS, FRAP and TAC) and antimicrobial activities, total phenolic contents and total flavonoid contents of the obtained extracts (hexane, ethyl acetate and methanol). The results showed that ethyl acetate extract from stems harvested in winter exhibited the highest antioxidant activity, while ethyl acetate extract from the stems harvested in spring showed the most potent antibacterial and antifungal activities. To explain these differences, we investigated the phytochemical composition of these two extracts using liquid chromatography coupled with mass spectrometry. Therefore, 45 compounds were detected, from which we identified 20 compounds (flavonoids, triterpenoids, chalcones and phenolic acids); some were specific to the harvest month while others were common for both periods. Some of the major compounds detected in ethyl acetate (spring) were dihydrochalcone (Kanzonol Y, 8.2%) and flavanone (sophoraflavanone G, 5.9%), previously recognized for their antimicrobial effects. We therefore concluded that the difference in activities observed for the two harvest periods depends on the chemical composition of the extracts and the relative abundance of each compound.

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Chemical characterization of extracts of leaves of Kadsua coccinea (Lem.) A.C. Sm. by UHPLC-Q-Exactive Orbitrap Mass spectrometry and assessment of their antioxidant and anti-inflammatory activities

Cited by 24 publications

References 22 publications

Rapid chemical characterization and pharmacological mechanism of Fining Granules in the treatment of chronic bronchitis based on UHPLC–Q-exactive orbitrap mass spectrometer and network pharmacology

Rapid chemical characterization and pharmacological mechanism of Fining Granules in the treatment of chronic bronchitis based on UHPLC–Q-exactive orbitrap mass spectrometer and network pharmacology

Exploring anti‐inflammatory and antioxidant‐related quality markers of Artemisia absinthium L. based on spectrum–effect relationship

Effect of the Harvest Season of Anthyllis henoniana Stems on Antioxidant and Antimicrobial Activities: Phytochemical Profiling of Their Ethyl Acetate Extracts

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