Chemical characterization of heteropolysaccharides from green and black teas ( Camellia sinensis ) and their anti-ulcer effect

Scoparo, Camila T.; Souza, Lauro Mera de; Dartora, Nessana; Sassaki, Guilherme L.; Santana-Filho, Arquimedes Paixão; Werner, Maria Fernanda de Paula; Borato, Débora G.; Baggio, Cristiane Hatsuko; Iacomini, Marcello

doi:10.1016/j.ijbiomac.2016.02.017

Cited by 31 publications

(27 citation statements)

References 52 publications

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“…The latter two were acidic heteropolysaccharide. Our results are similar to the studies in the literature showing that tea polysaccharides have arabinogalactan structures (Chen et al, 2009;Scoparo et al, 2016). Total phenolic content and antioxidant activities, using two different assays, were also determined ( Table 2).…”

Section: Compositional Characteristics and Antioxidant Activities Of supporting

confidence: 89%

α-Glucosidase inhibitory activities, functional properties, and safety of green tea polysaccharides as a potential source of dietary supplement

Karadağ¹,

Doğan²,

Pelvan³

et al. 2018

Journal of Food Bioactives

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Procuring valuable bioactive compounds from low quality green tea is of great interest. Green tea polysaccharides (GTPS), obtained from low quality tea leaves, were examined for their yield, monosaccharide composition, total phenolic content, antioxidant potential, and structures as well as molecular weight distribution and in vitro anti-diabetic activities. GTPS were also evaluated for their toxicity by performing cytotoxicity and genotoxicity. Additionally, 50% lethal dose (LD50) for GTPS was determined using an acute toxicity test to assess the safe use of it as a dietary supplement. Monosaccharides of GTPS were mainly composed of xylose, glucose, ribose, galactose, arabinose, and glucuronic acid. GTPS exhibited 91.86% α-glucosidase inhibition at 0.5 mg/mL concentration. The α-glucosidase inhibitory activity of GTPS was higher than that of pharmacological glucosidase inhibitor, acarbose, which exhibited only 47.86% inhibition at 2.5 mg/mL concentration. Neither cytotoxic nor no mutagenic effects were found for GTPS. The acute toxicity also showed that LD50 of GTPS was greater than 5,000 mg/kg. The present work suggests that GTPS can be considered as an anti-diabetic dietary supplement without posing any potential health risk.

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Section: Compositional Characteristics and Antioxidant Activities Of supporting

confidence: 89%

α-Glucosidase inhibitory activities, functional properties, and safety of green tea polysaccharides as a potential source of dietary supplement

Karadağ¹,

Doğan²,

Pelvan³

et al. 2018

Journal of Food Bioactives

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“…Furthermore, the pretreatment with Pu-erh tea extracts at moderate and high-dose caused significant reduction in the UI and inhibition of gastric mucosal injury. A study by Scoparo et al ( 43 ) demonstrated that the fraction of green and black tea containing heteropolysaccharides reduced gastric lesions induced with ethanol and protected gastric mucosa tissue. In the current study, it was identified that Pu-erh tea extracts clearly suppressed the formation of the gastric ulcer, and exhibited a higher inhibitory rate on gastric ulcer formation than green tea.…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, it was identified that Pu-erh tea extracts clearly suppressed the formation of the gastric ulcer, and exhibited a higher inhibitory rate on gastric ulcer formation than green tea. This observed effect is probably associated with the high content of polysaccharides present in Pu-erh tea extracts ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats

Yang

Zhou

et al. 2018

biom rep

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Pu-erh tea has become a focus of research due to its reported biological activities, including anti-oxidation, anti-inflammation and anti-immunosenescence. The present study was performed to evaluate the potential gastroprotective function of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats. Sprague Dawley rats were randomly divided into seven groups: A normal control, a model control, a cimetidine (0.08 g/kg) group, three Pu-erh tea extracts groups (low, moderate and high-dose; 0.50, 1.00 and 1.50 g/kg, respectively, and a green tea powder (1.00 g/kg) group. The normal and model groups were pre-treated with distilled water while the other groups were respectively administered cimetidine, Pu-erh tea extracts and green tea powder for 14 days. Then, absolute ethanol was orally administered to the rats of all groups excluding the normal controls. The effects of the pretreatments on gastric mucosal injury were evaluated by gross assessment of gastric lesions, examination of histopathology and determination of myeloperoxidase (MPO) activity and asymmetric arginine (ADMA) concentration in gastric mucosal homogenate. Pre-treatment with cimetidine or Pu-erh tea extracts markedly suppressed the formation of ethanol-induced gastric lesions. Furthermore, clear decreases in MPO activity and ADMA concentration in the gastric mucosal homogenate were observed following pretreatment with cimetidine or Pu-erh tea extracts. The anti-gastric ulcer activity of green tea was less than that of Pu-erh tea. Overall, these effects of Pu-erh tea extracts may be due to potential functions in protecting the gastric mucus layer and suppressing inflammation.

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“…In addition, tea has exhibited the neuro-protective effect, in terms of protecting against age-related neuro-degenerative disorders, depression and regulating the circadian clock [184][185][186][187][188][189][190]. Moreover, tea could inhibit gastric ulcer and improve gastrointestinal function [191][192][193][194][195]. Besides, tea could modulate gut microbiota composition (increase beneficial microorganisms and decrease harmful microorganisms), which might be beneficial to those in the risk of obesity, metabolic syndrome, hyperlipidemia, and cardiovascular diseases [196][197][198][199][200][201][202].…”

Section: Other Health Functionsmentioning

confidence: 99%

“…Wistar rats Gastrointestinal-protection Ameliorate gastric ulcer, by protecting gastric mucosa, reducing gastric lesions, and maintaining gastric mucus. [192] Polyphenols from dragon pearl tea 50, 100, or 200 mg/kg BW, 4 w Mice Gastrointestinal-protection Ameliorate gastric ulcer, by improving stomach acidity conditions, altering serum levels of SOD, GPX, CAT, MDA, and lipid peroxidation, increasing the mRNA expression levels of epidermal growth factor, epidermal growth factor receptor, vascular endothelial growth factor, and vascular endothelial growth factor receptor 1, and reducing gastrin expression levels. [195] Fuzhuan brick-tea 200 mg/kg BW, 8 w Rats Gastrointestinal-protection Improve the intestinal function of high-fat diet-fed to rats, by increasing two Lactobacillus spp in intestinal microbiota.…”

Section: Potential Safety Issuesmentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

270

150

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Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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Chemical characterization of heteropolysaccharides from green and black teas ( Camellia sinensis ) and their anti-ulcer effect

Cited by 31 publications

References 52 publications

α-Glucosidase inhibitory activities, functional properties, and safety of green tea polysaccharides as a potential source of dietary supplement

α-Glucosidase inhibitory activities, functional properties, and safety of green tea polysaccharides as a potential source of dietary supplement

Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

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