Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.

Silver, Jack; Russell, William A.; Reis, Brenda L.; Frelinger, Jeffrey A.

doi:10.1073/pnas.74.11.5131

Cited by 40 publications

(11 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both react with B lymphoid cells (15,22,23) and are potent inhibitors of mixed lymphocyte reactions (10,11,15,24). Also, incubation of target cells with F(ab)2 fragments of xenoantisera (12,25) (6,7,26) as well as shifts in molecular weights of presumedly HLA-D locus gene products p29 and p34 have been observed previously (20). The …”

Section: Methodsmentioning

confidence: 76%

“…The methods used for the isolation, purification, and sequence analysis of Ia alloantigens from murine spleen cells are identical to those previously published (6). The serological properties of the alloantisera (B10 X HTI)F1 anti-B1O.A (5R) and (A.TH X B1O.HTT)F1 anti-A.TL, used to isolate I-C subregion and I-A subregion molecules from B10.D2 and B10.A (4R) mice, respectively, have also been described (16).…”

Section: Methodsmentioning

confidence: 99%

“…By using specific alloantisera produced by cross-immunization of I region incompatible murine strains, two sets of la alloantigens have been identified. One, determined by the I-A subregion, consists of two chains of approximately 26,000 and 35,000 daltons (4,5); the other, determined by the I-C region, also consists of two chains with similar sizes (6,7). 1 1 Based on partial NH2-terminal sequence analysis, these two sets of molecules appear to be unrelated (6)(7)(8).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Murine Ia and human DR antigens: homology of amino-terminal sequences.

Allison¹,

Walker²,

Russell³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

110

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 76%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Murine Ia and human DR antigens: homology of amino-terminal sequences.

Allison¹,

Walker²,

Russell³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

110

View full text Add to dashboard Cite

show abstract

“…trols the cell surface expression of an Ia molecule whose polymorphic determinants are largely controlled by the I-A subregion. Cook, Vitetta, Uhr, and Capra (81) and later Silver et al (82) confirmed these findings and demonstrated that the I-E subregion controls the synthesis of the Ia Ea chain which on the cell surface is noncovalently associated with the p chain determined in the I-A subregion (Figs. 2 and 6).…”

Section: Function Of Ir Genesmentioning

confidence: 78%

Role of MHC Gene Products in Immune Regulation

Benacerraf

1981

Science

645

214

View full text Add to dashboard Cite

show abstract

“…Cook, Vitetta, Uhr and Capra (81) and later Silver et al (82) confirmed these findings and demonstrated that the 1-E subregion controls the synthesis of the Ia Ea chain which on the cell surface is noncovalently associated with the β chain determined in the I-A subregion (Figs. 2 and 6).…”

Section: The La Molecules Are the Ir Gene Productsmentioning

confidence: 77%

The Role of MHC Gene Products in Immune Regulation and its Relevance to Alloreactivity

Benacerraf¹

1992

Scand J Immunol

View full text Add to dashboard Cite

The immune system has evolved the capacity to react specifically with a very large number of foreign molecules with which it had no previous contact, while avoiding reactivity for autologous molecules, naturallyantigenic in other species or in other individuals of the same species.Immunological research has been directed to the elucidation of this phenomenon ever since Ehrlich (1) proposed that immunocompetent cells bear receptors for antigen identical with the antibodies to be produced. Gowans (2) identified lymphocytes as the cells responsible for immune phenomena. Burnet (3) proposed the clonal selection theory of immunity which postulated that: 1) lymphocytes differentiate as clones bearing antibody receptors of unique specificity, 2) antibody responses reflect the selective expansion of specific lymphocytes, following the binding of antigen, and their differentiation as secretors of antibody, identical in specificity with the antigen binding receptors on the original clones. The Burnet hypothesis was verified experimentally (4,5,6) and was accepted as a major advance, concerned primarily with the response of antibody producing cells, later identified as B lymphocytes (7) and plasma cells. Accordingly, studies on the specificity of antibodies and on the structure of immunoglobulins revealed that these molecules (8,9) and their structural genes (10,ll) evolved in a way that ensures the enormous diversity of antibody combining sites observed.The discovery by Miller (12) and by Good (13) that lymphocytes differentiate into two separate classes of cells (T and B) with distinct functions, the identification of cellular immune phenomena mediated by T cells (14) and the demonstration that immune responses are regulated by helper (15,16,17) and suppressor (18,19) cells and by macrophages (20) emphasized the complexity of the immune system and the critical role played by T lymphocytes in the regulation of immunity.It became increasingly apparent that the clonal selection theory, although correct, did not take into account the complex cellular and molecular interactions essential to immune phenomena or the restrictions these interactions dictate in the specificity of T cells. An additional system, beside specific immunoglobulins, involving the products of the major histocompatibility complex (MHC) was shown to be critically involved in the manner by which T cells 597

show abstract

Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.

Cited by 40 publications

References 34 publications

Murine Ia and human DR antigens: homology of amino-terminal sequences.

Murine Ia and human DR antigens: homology of amino-terminal sequences.

Role of MHC Gene Products in Immune Regulation

The Role of MHC Gene Products in Immune Regulation and its Relevance to Alloreactivity

Contact Info

Product

Resources

About