Chemical characterization of the oligosaccharides in Bactrian camel (Camelus bactrianus) milk and colostrum

Fukuda, Kenji; Yamamoto, Aiko; Ganzorig, Khuukhenbaatar; Khuukhenbaatar, J.; Senda, Akitsugu; Saito, Tadao; Urashima, Tadasu

doi:10.3168/jds.2010-3151

Cited by 57 publications

(39 citation statements)

References 26 publications

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“…along with lacto-N-neotetraose (LNnT, Gal(1-4)GlcNAc(1-3)Gal(1-4)Glc) and lacto-N-neohexaose (LNnH, Gal(1-4)GlcNAc(1-3)[Gal(1-4)GlcNAc(1-6)]Gal(1-4)Glc). [16][17][18] Subsequently to these studies, no structural investigation of acidic and neutral oligosaccharides of bovine milk/colostrum were performed …”

Section: Historical Aspects Of Bmo Studiesmentioning

confidence: 99%

“…17) A highly negatively charged fraction contained oligosaccharides which were assumed to be phophorylated sialyl oligosaccharides, as well as DSL and disialyllactosamine. Neu5Gc-containing oligosaccharides constituted less than 5% of the acidic oligosaccharide fraction, and very small amounts of O-acetylated sialyllactose and sialyllactosamine were detected.…”

Section: Recent Studies Of Bovine Milk Oligosaccharidesmentioning

confidence: 99%

“…The oligosaccharides in Bactrian camel milk and colostrum were characterized by Fukuda et al (2010). 17) They were separated and purified by extraction of carbohydrate with chloroform/methanol, gel filtration, anion exchange chromatography, and normal phase HPLC with an Amide-80 column, and were characterized by 0 -GL, sialyl lacto-N-novopentaose a, and sialyl LNnH.…”

Section: Milk Oligosaccharides Of Domestic Farm Animals Other Thamentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances in Studies on Milk Oligosaccharides of Cows and Other Domestic Farm Animals

Urashima

Taufik

Fukuda

et al. 2013

Bioscience, Biotechnology, and Biochemistry

197

142

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Section: Historical Aspects Of Bmo Studiesmentioning

confidence: 99%

Section: Recent Studies Of Bovine Milk Oligosaccharidesmentioning

confidence: 99%

Section: Milk Oligosaccharides Of Domestic Farm Animals Other Thamentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Studies on Milk Oligosaccharides of Cows and Other Domestic Farm Animals

Urashima

Taufik

Fukuda

et al. 2013

Bioscience, Biotechnology, and Biochemistry

197

142

View full text Add to dashboard Cite

“…Increased concentrations of HMOs in breast milk have been associated with decreased HIV transmission during breastfeeding (11). In addition, in comparison to the milks of the other species evaluated here, including RM, the oligosaccharides present in human breast milk are more abundant and diverse (32,36,40,41). Furthermore, HMOs are not affected by Holder pasteurization and are present in the skim fraction of breast milk (38).…”

Section: Resultsmentioning

confidence: 85%

Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity

Wahl

Baker

Spagnuolo

et al. 2015

J Virol

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Despite the nutritional and health benefits of breast milk, breast milk can serve as a vector for mother-to-child HIV transmission. Most HIV-infected infants acquire HIV through breastfeeding. Paradoxically, most infants breastfed by HIV-positive women do not become infected. This is potentially attributed to anti-HIV factors in breast milk. Breast milk of HIV-negative women can inhibit HIV infection. However, the HIV-inhibitory activity of breast milk from HIV-positive mothers has not been evaluated. In addition, while significant differences in breast milk composition between transmitting and nontransmitting HIVpositive mothers have been correlated with transmission risk, the HIV-inhibitory activity of their breast milk has not been compared. This knowledge may significantly impact the design of prevention approaches in resource-limited settings that do not deny infants of HIV-positive women the health benefits of breast milk. Here, we utilized bone marrow/liver/thymus humanized mice to evaluate the in vivo HIV-inhibitory activity of breast milk obtained from HIV-positive transmitting and nontransmitting mothers. We also assessed the species specificity and biochemical characteristics of milk's in vivo HIV-inhibitory activity and its ability to inhibit other modes of HIV infection. Our results demonstrate that breast milk of HIV-positive mothers has potent HIV-inhibitory activity and indicate that breast milk can prevent multiple routes of infection. Most importantly, this activity is unique to human milk. Our results also suggest multiple factors in breast milk may contribute to its HIV-inhibitory activity. Collectively, our results support current recommendations that HIV-positive mothers in resource-limited settings exclusively breastfeed in combination with antiretroviral therapy. IMPORTANCEApproximately 240,000 children become infected with HIV annually, the majority via breastfeeding. Despite daily exposure to virus in breast milk, most infants breastfed by HIV-positive women do not acquire HIV. The low risk of breastfeeding-associated HIV transmission is likely due to antiviral factors in breast milk. It is well documented that breast milk of HIV-negative women can inhibit HIV infection. Here, we demonstrate, for the first time, that breast milk of HIV-positive mothers (nontransmitters and transmitters) inhibits HIV transmission. We also demonstrate that breast milk can prevent multiple routes of HIV acquisition and that this activity is unique to human milk. Collectively, our results support current guidelines which recommend that HIV-positive women in resource-limited settings exclusively breastfeed in combination with infant or maternal antiretroviral therapy. Breast milk provides newborn infants with all of their daily nutritional and fluid requirements. It is also a rich source of hormones, antimicrobial factors, and immune components that decrease the susceptibility of breastfed infants to infectious diseases (1). For these reasons, the World Health Organization (WHO) recommends that mothe...

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“…Milk oligosaccharides of many mammals have been studied (13,14,(75)(76)(77)(78)(79)(80)(81). However, studies from non-primate mammals are difficult to compare in quantitative terms because comprehensive profiling have not been performed.…”

Section: Classification Of Primates Based On Milk Oligosaccharide Strmentioning

confidence: 99%

Analysis and role of oligosaccharides in milk

Ruhaak

Lebrilla

2012

BMB Reports

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Chemical characterization of the oligosaccharides in Bactrian camel (Camelus bactrianus) milk and colostrum

Cited by 57 publications

References 26 publications

Recent Advances in Studies on Milk Oligosaccharides of Cows and Other Domestic Farm Animals

Recent Advances in Studies on Milk Oligosaccharides of Cows and Other Domestic Farm Animals

Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity

Analysis and role of oligosaccharides in milk

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