Chemical Characterization of Volatile Extract of Artemisia Herba-Alba and Study of Its Antioxidant, Antimicrobial and Antifungal Activities and Its Inhibitionory Effect on Corrosion of Aluminum in Hydrogen Chloride Solution

Ouchelli, Yamen; Dahmani, Nacera; Addi, Yassine; Hechiche, Nacer; Baaliouamer, Aoumar

doi:10.55251/jmbfs.4889

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…As a member of the Asteraceae family, Artemisia is among several genera known for its richness in secondary metabolites and essential oils, which possess valuable therapeutic applications. In this aspect, AHA extracts have been shown a broad antibacterial action ( Daoudi et al , 2022 ; Ouchelli et al , 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-MRSA and cytotoxic activities of different solvent extracts from Artemisia herba-alba grown in Shubak, Jordan

Alghonmeen,

Dmour,

Saghir

et al. 2024

Open Vet J

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Background: Globally, resistance to antimicrobial drugs is a major hazard to public health. Infections that were once easily treatable with antibiotics are becoming harder to control, leading to prolonged illnesses, increased mortality rates, and higher healthcare costs. Aim: This study intended to assess the antimicrobial, specifically the anti- Methicillin-resistant Staphylococcus aureus (MRSA) , and anticancer properties of different extracts obtained from A. herba-alba (AHA). Methods: The antibacterial tests of AHA were performed on two Gram-negative bacterial strains (Escherichia coli and Klebsiella pneumonia), two Gram-positive bacterial strains (Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus). Initial screening for antibacterial activities was conducted using the agar-disc diffusion technique. Subsequently, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined through the broth-dilution assay. The anticancer test was carried out in vitro on a human colorectal carcinoma cell line (HCT-116) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) )MTT( method. Results: Among all extracts, n-hexane extract of AHA was the most effective against S. aureus with the highest inhibition zone (24.67 mm) comparing to standard antibiotic (erythromycin, 24.00 mm) followed by the methanolic extract against MRSA (24.00 mm). The methanol extract of AHA showed the highest antibacterial activity against MRSA. The results of MIC and MBC of the AHA methanol extract against MRSA were 1.17±1.09 mg/mL and 9.375±0.0 mg/mL, respectively demonstrated therapeutically significant antibacterial activity. Ethyl acetate extract has no antibacterial activity against E. coli and K. pneumonia. The findings indicated that the methanol extract of AHA exhibited the highest efficacy against the colorectal carcinoma cell line (HCT-116), with an IC50 value of 126.61±13.35 µg/mL. Conclusion: These findings suggest that methanol extract of AHA could be considered as a potential agent to serve as a source of antibacterial and anticancer compounds.

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Section: Discussionmentioning

confidence: 99%

Anti-MRSA and cytotoxic activities of different solvent extracts from Artemisia herba-alba grown in Shubak, Jordan

Alghonmeen,

Dmour,

Saghir

et al. 2024

Open Vet J

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Phytochemical analysis, in vitro antioxidant and antifungal activities of extracts and essential oil derived from Artemisia herba-alba Asso

EL Hajli,

Kachmar,

Assouguem

et al. 2024

Open Chemistry

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Artemisia herba-alba Asso is an endemic plant from North-East Morocco offering a diverse range of pharmacological, cosmetic, and agro-ecological uses. However, Artemisia herba-alba has not been well exploited in the field of plant protection (post-harvest diseases). This is why the main objective of the present study is to evaluate the antifungal and antioxidant activities of extracts or the essential oil of this plant. Antifungal activity was assessed against Botrytis cinerea, Penicillium expansum, and Penicillium digitatum using the agar dilution method for the aqueous extracts and fumigation for the essential oil. Antioxidant activity was assessed using the DPPH scavenging test and the FRAP ferric ion reduction capacity. The chemical composition of the extracts was determined by HPLC and that of the essential oil by GC-MS/MS. In addition, the polyphenol, flavonoid, and tannin content was determined using colorimetric methods. The results of this study showed that the total content of polyphenols (217.60 mg GAE/g E), flavonoids (43.59 mg QE/g E), and tannins (32.58 mg GAE/g E) was significantly higher (p ≤ 0.05) in the ethanolic extract than in the aqueous and hexanoic extracts. Moreover, the HPLC analysis of the aqueous extract revealed the presence of six compounds, namely, catechin, gallic acid, hydroxybenzoic acid, syringic acid, caffeic acid, and rutin. In addition, the ethanolic extract was found to contain seven phenolic compounds. On the one hand, 35 compounds were identified in the essential oil of Artemisia herba-alba, representing 99.7% of the total. According to this study, the dominant compounds in the essential oil of Artemisia herba-alba Asso are camphor (46.57%), endo-borneol (5.65%), eucalyptol (5.64%), and thymol (3.85%). Furthermore, the biological evaluation showed that the extracts and essential oil of Artemisia herba-alba have significant antioxidant and antibacterial activities. The findings show that Artemisia herba-alba is a plant that can be used as a source of antifungal chemicals to prevent putrefaction of foodstuffs and, more specifically, postharvest diseases.

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Variability of the component composition of the essential oil of <i>Artemisia salsoloides</i> Willd. from natural populations of the flora of Dagestan

Vagabova,

Aliev,

Radzhabov

et al. 2024

Ûg Ross.: èkol. razvit.

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To study the variability of the gathering locality and componen t composition of essential oil from the aerial part of a little‐studied species – Artemisia salsoloides Willd. depending on abiotic environmental factors, such as height above the level of the place of growth. Aerial parts of A. salsoloides were collected during the flowering phase in four Dagestan natural populations to obtain essential oil using the Clevenger method. To determine the component composition of the samples obtained of essential oils of A. salsoloides, chromatography‐mass spectrometric analysis was used. The components were identified using the NIST08 and FFNSC mass spectral libraries. In total, 55 compounds were identified in the essential oil samples, where monoterpenoids account for 59.92 % – 75.98 % and sesquiterpenoids – for 23.24 % to 37.81 %. At the same time, 15 major compounds were identified. Thus, it should be noted that there was found to be a wide range of values for monoterpenoids: β‐pinene, trans‐β‐ocimene, cis‐alloocimene, benzene, 2,4‐pentadinyl, and among sesquiterpenoids – α‐copaene, β‐sesquiphilandrene, spathulenol. The quantitative yield of essential oil in the studied samples varied from 0.68 % to 1.36 % of airdried raw materials, depending on the growth location of the species. Four separate populations of A. salsoloides were identified by means of cluster analysis based on the component composition of the studied essential oils. For the first time, the composition of the essential oil of the aerial part of wild Dagestan samples of A. salsoloides was studied as depending on an abiotic factor (height above sea level) of the environment. The results obtained of the component composition of the essential oil of A. salsoloides samples showed the presence of a number of valuable compounds, which allow the use of essential oils as their sources.

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Chemical Characterization of Volatile Extract of Artemisia Herba-Alba and Study of Its Antioxidant, Antimicrobial and Antifungal Activities and Its Inhibitionory Effect on Corrosion of Aluminum in Hydrogen Chloride Solution

Cited by 3 publications

References 28 publications

Anti-MRSA and cytotoxic activities of different solvent extracts from Artemisia herba-alba grown in Shubak, Jordan

Anti-MRSA and cytotoxic activities of different solvent extracts from Artemisia herba-alba grown in Shubak, Jordan

Phytochemical analysis, in vitro antioxidant and antifungal activities of extracts and essential oil derived from Artemisia herba-alba Asso

Variability of the component composition of the essential oil of <i>Artemisia salsoloides</i> Willd. from natural populations of the flora of Dagestan

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