Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Viii. Clinical Use of Concentrated Human Serum Albumin in Shock, and Comparison With Whole Blood and With Rapid Saline Infusion 12

Cournand, André; Noble, Robert P.; Breed, Ernest S.; Lauson, Henry D.; Baldwin, E. De F.; Pinchot, G. B.; Richards, Dickinson W.

doi:10.1172/jci101515

Cited by 41 publications

(13 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, small amounts of albumin subsequently have been allocated to two groups of investigators, whose detailed studies of selected shock cases might contribute information of value to the armed forces. The results of these investigations are presented in subsequent papers in this series (7,8). The results in the original group of 200 cases have been previously reported (9).…”

Section: Introductionmentioning

confidence: 75%

Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Vii. Concentrated Human Serum Albumin 123

Janeway¹,

Gibson²,

Woodruff³

et al. 1944

J. Clin. Invest.

106

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 75%

Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Vii. Concentrated Human Serum Albumin 123

Janeway¹,

Gibson²,

Woodruff³

et al. 1944

J. Clin. Invest.

106

View full text Add to dashboard Cite

“…Varying degrees of shock were encountered. Additional information regarding the criteria used in evaluating the degree of shock, the general procedures followed, and other results have been reported by Cournand et al (8,12), by Lauson et al (13), and by Richards (14).…”

Section: Methodsmentioning

confidence: 86%

Blood Volume in Clinical Shock. Ii. The Extent and Cause of Blood Volume Reduction in Traumatic, Hemorrhagic, and Burn Shock12

Noble¹,

Gregersen²,

Porter³

et al. 1946

J. Clin. Invest.

View full text Add to dashboard Cite

found evidence of a direct relation between the severity of shock and the extent of the reduction in blood volume. This has been clearly demonstrated in recent experimental studies on traumatic and hemorrhagic shock in dogs (4, 5) in which blood volume was determined with more dependable methods. Within the past two years, there have also been reports of similar observations on cases of shock among civilians (6, 7, 8, and others).The aim of the present investigation was: (1) to determine more precisely the relation between the loss in blood volume and the severity of shock in man, in order to provide a sound basis for estimating the amount of blood needed for replacement after various types and degrees of injury; (2) to determine the cause of blood volume reduction in traumatic shock; and, (3) to test the view, held until recently by some investigators, that hemoconcentration is a criterion of shock. MATERIAL AND METHODSThe plasma volume was measured with T-1824 by extrapolation of a corrected time log-concentration curve as described in the preceding report (9) ; the total blood volume was calculated from the plasma volume and the arterial hematocrit. The serum protein concentration was determined by the falling drop (10) and refractometric.

show abstract

“…One occurred one week after the last previous albumin infusion, one five days after, and the third patient had hematemesis six hours after an infusion which was pyrogenic. Although in cirrhosis with varices hemorrhage may occur at any time, albumin may have been a precipitating factor by increasing the plasma volume (9).…”

Section: Resultsmentioning

confidence: 99%

An Evaluation of Human Serum Albumin in the Treatment of Cirrhosis of the Liver 12

Ww¹,

Rd²,

Tl³

et al. 1949

J. Clin. Invest.

View full text Add to dashboard Cite

Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Viii. Clinical Use of Concentrated Human Serum Albumin in Shock, and Comparison With Whole Blood and With Rapid Saline Infusion 12

Cited by 41 publications

References 4 publications

Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Vii. Concentrated Human Serum Albumin 123

Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Vii. Concentrated Human Serum Albumin 123

Blood Volume in Clinical Shock. Ii. The Extent and Cause of Blood Volume Reduction in Traumatic, Hemorrhagic, and Burn Shock12

An Evaluation of Human Serum Albumin in the Treatment of Cirrhosis of the Liver 12

Contact Info

Product

Resources

About