Chemical Components from <i>Phaeanthus vietnamensis</i> and Their Inhibitory <scp>NO</scp> Production in <scp>BV</scp>2 Cells

Nhiệm, Nguyễn Xuân; Tuong, Nguyen Trung; Kỳ, Phạm Thanh; Subedi, Lalita; Park, Seon Ju; Ngoc, Tran Minh; Yến, Phạm Hải; Tài, Bùi Hữu; Quang, Trần Hồng; Kiệm, Phan Văn; Kim, Sun Yeou; Kim, Seung Hyun

doi:10.1002/cbdv.201700013

Cited by 18 publications

(12 citation statements)

References 13 publications

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“…The NOE correlation between H‐7 and H‐7′ in conjunction with the orientation of the A1 ring deduced above revealed the relative configuration of C‐7 as ( R ). Moreover, the CD spectrum of 1 showed a positive peak at 208 nm, which is similarly to that of (7 S ,8 R ,8′ R )‐3,3′,5,5′‐tetramethoxy‐9,9′‐epoxylignan‐4,4′,7‐triol, further indicating that the configuration at C‐7 is ( R ) [13] . The absolute configurations of 1 were confirmed by comparing its experimental ECD spectrum with calculated data.…”

Section: Resultsmentioning

confidence: 60%

“…Moreover, the CD spectrum of 1 showed a positive peak at 208 nm, which is similarly to that of (7S,8R,8'R)-3,3',5,5'-tetramethoxy-9,9'-epoxylignan-4,4',7-triol, further indicating that the configuration at C-7 is (R). [13] The absolute configurations of 1 were confirmed by comparing its experimental ECD spectrum with calculated data. The ECD spectra of the two enantiomers calculated by time-dependent density-functional theory (TDDFT) of 1a (7R,8S,7'R,8'S) and 1b (7S,8R,7'S,8'R) are shown in Figure 4.…”

Section: Resultsmentioning

confidence: 87%

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Neuraminidase Inhibitors from the Roots of Caragana sinica

Park

Kim

Nhiệm

et al. 2020

Chemistry & Biodiversity

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Two new oligostilbenes, caragasinins D and E, along with four known compounds, kobophenol A, α-viniferin, wistin, and 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid, were isolated from the roots of Caragana sinica. These compounds were spectroscopically analyzed for their structures and configurations and compared with existing data. The configurations of caragasinins D and E were elucidated by 1 H-NMR spectroscopy, CD spectroscopy, and time-dependent density-functional theory simulated ECD spectral data. All six compounds were evaluated for their inhibitory activity against neuraminidase (NA) from Clostridium perfringens. Among the tested compounds, 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid demonstrated statistically significant NA inhibitory activity, which was comparable to the positive control, mangiferin.

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Section: Resultsmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 87%

Neuraminidase Inhibitors from the Roots of Caragana sinica

Park

Kim

Nhiệm

et al. 2020

Chemistry & Biodiversity

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“…13,14 In this work, the anti-inflammatory activity of compounds 1-8 was evaluated by their inhibiting effect on NO production in LPS-stimulated BV2 cells. 15 At a high concentration up to 80 µM, compounds 1-8 did not show any cytotoxic effect on the BV2 cells (cell viability in range from 96.2% ± 2.0% to 113.2% ± 4.3%, Table 2). Thus, the NO inhibitory activity of the compounds was not affected by cytotoxic activity.…”

Section: Resultsmentioning

confidence: 86%

New Neolignan and Dihydrostilbene Derivatives from Pouzolzia sanguinea Inhibit NO Production in LPS-Activated BV2 Cells

Nhung

Phan

Thủy

et al. 2020

Natural Product Communications

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Three dihydrostilbene derivatives (1-3) and 5 neolignans (4-8) were isolated from the ethyl acetate-soluble fraction of Pouzolzia sanguinea. Two new compounds (1 and 4) were obtained. Their structures, as well as their absolute configuration, were elucidated by means of high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance, and circular dichroism spectral data. Compounds 1-8 inhibited NO production in lipopolysaccharide-activated BV2 cells with half-maximal inhibitory concentration (IC50) values ranging from 22.7 ± 1.5 to 61.2 ± 3.1 µM. Of these, compounds 1 and 2 exhibited the most NO inhibitory activity with IC50 values of 22.7 ± 1.5 and 25.1 ± 2.1 µM, respectively, in comparison with the positive control, NG-monomethyl-L-arginine, IC50 value 22.1 ± 1.2 µM.

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“…This plant is considered important as it is used to season different food products. Spathulenol, a bioactive constituent isolated from this plant, showed considerable activity against NO production upon LPS stimulation, suggesting the potential value of this compound for treating neurodegenerative diseases [ 94 ].…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy

Subedi

Gaire

Parveen

et al. 2021

IJMS

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Nitric oxide (NO) is a neurotransmitter that mediates the activation and inhibition of inflammatory cascades. Even though physiological NO is required for defense against various pathogens, excessive NO can trigger inflammatory signaling and cell death through reactive nitrogen species-induced oxidative stress. Excessive NO production by activated microglial cells is specifically associated with neuroinflammatory and neurodegenerative conditions, such as Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis, ischemia, hypoxia, multiple sclerosis, and other afflictions of the central nervous system (CNS). Therefore, controlling excessive NO production is a desirable therapeutic strategy for managing various neuroinflammatory disorders. Recently, phytochemicals have attracted considerable attention because of their potential to counteract excessive NO production in CNS disorders. Moreover, phytochemicals and nutraceuticals are typically safe and effective. In this review, we discuss the mechanisms of NO production and its involvement in various neurological disorders, and we revisit a number of recently identified phytochemicals which may act as NO inhibitors. This review may help identify novel potent anti-inflammatory agents that can downregulate NO, specifically during neuroinflammation and neurodegeneration.

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Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells

Cited by 18 publications

References 13 publications

Neuraminidase Inhibitors from the Roots of Caragana sinica

Neuraminidase Inhibitors from the Roots of Caragana sinica

New Neolignan and Dihydrostilbene Derivatives from Pouzolzia sanguinea Inhibit NO Production in LPS-Activated BV2 Cells

Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy

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