Chemical composite of indigenous whole grain scented joha rice varietal prevents type 2 diabetes in rats through ameliorating insulin sensitization by the IRS-1/AKT/PI3K signalling cascade

Abstract

Preventive measures of prevalence type-2 diabetes development by dietary phytochemicals is more realistic. Whole grain scented joha rice- (indigenous to NER, India) derived phytochemicals composite (PCKJ) was investigated to understand...

The Associations between Healthy Eating Patterns and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Case–Control Study

“…Healthy eating patterns were characterized by richness in high-quality carbohydrates, fresh fruits and vegetables, and legumes and nuts [ 34 ]. The nutrients abundant in healthy eating patterns like fiber, phytochemicals, and magnesium were effective in alleviating insulin resistance [ 35 , 36 , 37 ]. For instance, 8-week treatment with alginate and β-glucan in obese C57BL/6J mice improved glucose metabolism and insulin sensitivity by inactivating the c-Jun- N -terminal kinases signaling [ 35 ], and a 24-week intervention with phytochemicals in rats reduced blood glucose levels and enhanced insulin sensitization by upregulating Phosphoinositide 3-kinase, Phosphorylated Protein Kinase B, and Glucose transporter type 4 levels in the skeletal tissue [ 36 ].…”

“…The nutrients abundant in healthy eating patterns like fiber, phytochemicals, and magnesium were effective in alleviating insulin resistance [35][36][37]. For instance, 8-week treatment with alginate and β-glucan in obese C57BL/6J mice improved glucose metabolism and insulin sensitivity by inactivating the c-Jun-N-terminal kinases signaling [35], and a 24-week intervention with phytochemicals in rats reduced blood glucose levels and enhanced insulin sensitization by upregulating Phosphoinositide 3-kinase, Phosphorylated Protein Kinase B, and Glucose transporter type 4 levels in the skeletal tissue [36]. Evidence from RCTs also demonstrated that inter-ventions promoting a high-quality dietary pattern could improve insulin resistance [28].…”

Effects and mechanisms of anti-diabetic dietary natural products: an updated review

“…60 Another study showed that whole grain scented joha rice decreased blood glucose and interferon gamma (IFN-γ) in the skeletal tissue of STZ-induced diabetic male albino Wistar rats. 61 On the whole, certain dietary natural products, such as the date palm fruit and whole grain scented joha rice, can decrease blood glucose and restore β cell functions via normalizing the levels of inflammatory factors, such as IL-1β, IL-6 and TNF-α. In the future, the impacts of more anti-inflammatory dietary natural products on diabetes need to be studied.…”

“…67 Additionally, scented joha rice increased glucose uptake by promoting the translocation of the glucose transporter class 4 (GLUT-4) into the cell plasma membrane, which was activated by the IRS/PI3K/AKT pathway. 61 Moreover, polyphenols from the fruit of Rosa roxburghii promoted glycogen storage by down-regulating the PI3K/AKT downstream effector GSK3β, as well as by inhibiting gluconeogenesis by reducing the expression of FOXO1. 68 Apart from the details mentioned above, the PI3K/AKT pathway could be also activated by some dietary natural products.…”

“…60 Another study showed that whole grain scented joha rice decreased blood glucose and interferon gamma (IFN-γ) in the skeletal tissue of STZ-induced diabetic male albino Wistar rats. 61…”