Chemical composition and antibacterial activity of the essential oils of Ferula vesceritensis Coss et Dur. leaves, endemic in Algeria

Abstract

BackgroundThe biological importance of members of genus Ferula promoted us to investigate the leaves of Ferula vesceritensis Coss et Dur. (endemic plant) previously not investigated. This study presents the chemical composition and antibacterial activities of the hydrodistilled oils.ResultsVolatile components of the leaves of F. vesceritensis have been studied by gas chromatography–mass spectrometry to afford 23 compounds. The major components were found to be 5,9-tetradecadiyne (24.72%), germacrene D (24.51%), farnesene (8.57%), and α-bisabolene (8.57%). The antimicrobial activities of the essential oils were evaluated by disk diffusion method and tested against Gram-positive and Gram-negative bacteria. The volatile oil showed a strong antibacterial activity against Staphylococcus aureus, Escherichia coli, and Klebsiella pneumonia.ConclusionsThese results reinforce the previous studies showing that the genus Ferula is considered as a good source of essential oils. The results presented here can be considered as the first information on the antimicrobial properties of F. vesceritensis.

Untitled

“…In the SC-CO 2 extract at 40°C, 100 bar ( Table 3), compounds with antimicrobial potency such as acetophenone 13 , alpha-farnesene and betabisabolene 14 , eugenol 15 and methyl eugenol 16 have been identified. For the extract obtained at 60°C, 200 bar, in addition to eugenol, styrene was also detected which is known to be an antimicrobial agent 17 , shown in Table 4.…”

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

“…However, elemene sesquiterpenoids are not common secondary metabolites of Ferula species. There are five published essential oil analyses of F. vesceritensis in the literature and just one of them reports elemene sesquiterpene (i.e., shyobunol) as its major component (i.e., 18.1%) [162][163][164][165][166]. Furthermore, comparisons of essential oil analyses of Ferula species from Turkey and Iran indicate that out of 35 Ferula species analyzed by GC-MS, only one species, F. drudeana, contains a high level of elemenetype sesquiterpenoids [54,167,168].…”

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

“…Essential oils are plant extracts that contain mixtures of terpenes and have a wide range of pharmacological activities [8]. For example, essential oils extracted from various Ferula species have been reported to exhibit antioxidant, antiinflammatory, anti-mutagenic, antimicrobial, and antifungal activities [9][10][11][12][13][14][15]. Although essential oils from various Ferula species have been shown to contain monoterpenes, sesquiterpenes, and polysulfides [14,[16][17][18][19][20][21][22], the chemical composition of essential oils isolated from many native Ferula spp.…”