Chemical composition and antibacterial activity of essential oils from various parts of Gladiolus  candidus, Ranunculus multifidus, Artemisia abyssinica and Crinum abyscinicum

Tesfay, Dawit; Endale, Milkyas; Getaneh, Emebet; Abdisa, Eticha; Guta, Leta; Melaku, Yadessa

doi:10.4314/bcse.v36i4.12

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…According to the literature, no studies on the identification of C. mildbraedii bark essential oil components have been published. The components of the essential oil were identified by comparing their MS patterns and retention index (RI) with those of known chemicals published in the literature [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. The chemical composition of the essential oil of C. mildbraedii bark was quantified using GC-FID and identified via GC-MS. Table 5 shows 30 compounds identified, representing 65% of all compounds detected in the GC-MS investigation of the essential oil, with 9 sesquiterpene hydrocarbons (26%), 7 oxygenated sesquiterpenes (22%) and 14 other compounds (17%).…”

Section: Resultsmentioning

confidence: 99%

Copaifera mildbraedii Desf.: Phytochemical Composition of Extracts, Essential Oil, and In Vitro Biological Activities of Bark

Namkona,

Rahmani,

Worowounga

et al. 2024

Plants

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Copaifera mildbraedii Desf. is an evergreen tree with an umbrella-like crown. It is distributed from south-eastern Nigeria eastward to the Central African Republic (CAR). The aim of this study was to assess the chemical composition and biological activities of C. mildbraedii bark, as well as the chemical composition of the essential oil. Ethyl acetate (EtOAc) and methanol (MeOH) extracts showed a high total phenolic content (TPC) (149.9 and 148.8 mg GAE/g dry residue (dr), respectively), which was related to good antioxidant activity (DPPH) with an IC50 of 21.2 and 12.9 µg/mL, respectively. High-performance liquid chromatography coupled with diode array detector (HPLC-DAD) analysis revealed seven phenolic compounds with myricitrin (13.3 mg/g dr) and 2,4-dihydroxy-3,6-dimethyl benzoic acid (30.7 mg/g dr) as major compounds, while gas chromatography-mass spectrometry (GC-MS) analysis enabled detection of 13 volatile compounds (3 before and 10 after derivatization). Thirty compounds were identified in the essential oil, which corresponds to 65% of all identified compounds. Among the latter, E,E-farnesylacetone and γ-gurjunene were considered as major compounds (8.08 and 10.43%, respectively). The EtOAc extract showed a potent potential, simultaneously, against anti-acetylcholinesterase (AChE), anti-15-lipoxygenase (15-LOX), anti-xanthine oxidase (XOD), and cytotoxic (OVCAR) activities, whereas cyclohexane (CYHA) and dichloromethane (DCM) extracts showed a cytotoxic effect with high percentages of inhibition (95.2%).

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Section: Resultsmentioning

confidence: 99%

Copaifera mildbraedii Desf.: Phytochemical Composition of Extracts, Essential Oil, and In Vitro Biological Activities of Bark

Namkona,

Rahmani,

Worowounga

et al. 2024

Plants

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“…176,177 Of the medicinal plants employed to treat human health problems, Justicia schimperiana, Embelia schimperi, Olinia rochetiana and Euclea schimperi which were used to treat liver disorders, tapeworm infection, general gastrointestinal complaints, and skin diseases, respectively, scored the highest FL and ROP values, which are measures of therapeutic potential. 35 Justicia schimperiana was reported to have shown antioxidant, 178 lousicidal and acaricidal, 179 anticancer 180 and antimalarial 181 activities. Crude extracts of Embelia schimperi exhibited anthelmintic 182 and antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

Medicinal Plants Used by Oromo Community in Kofale District, West-Arsi Zone, Oromia Regional State, Ethiopia

Nuro,

Tolossa,

Giday

2024

JEP

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Purpose The purpose of this study was to record the utilization of medicinal plants by the Oromo people in the Kofale District, Oromia Regional State, Ethiopia, to control human and animal health problems. Methods Data regarding the use of medicinal plants were collected using ethnobotanical methods from 84 traditional medicine practitioners and 304 general informants sampled employing purposive and systematic random sampling methods, respectively, in the Kofale District. Data were analyzed using different indices, including a preference ranking exercise, informant consensus factor (ICF), fidelity level (FL) and relative popularity level (RPL). Results In the district, 106 medicinal plants were claimed to be used for the treatment of 43 human and 18 livestock illnesses, of which 75 (71%) were used to manage human health problems, 23 (21.5%) were used to treat both human and livestock ailments and eight (7.5%) were utilized to treat manage livestock health problems. Most (76.4%) plants were harvested from the wild. Leaves were the most commonly used plant part (55.6%) in remedy preparations. Skin diseases scored the highest ICF value (0.97), followed by gastrointestinal disorders (ICF = 0.95), cancer (ICF = 0.93), and hemorrhoids (ICF = 0.91). Medicinal plants that record the highest fidelity level (FL) (100%) and rank order priority (ROP) (100%) values included Justicia schimperiana, Embelia schimperi, Ekebergia capensis and Datura stramonium , which have been used to treat liver disorders, tapeworm infections, babesiosis, and rabies, respectively. There were significant differences ( p <0.05) in the mean numbers of medicinal plants claimed by different social groups: older, illiterate, and traditional medicine practitioners reported higher mean numbers of medicinal plants than younger, literate, and general informants, respectively. Conclusion This study indicated the richness of medicinal plant species in Kofale District. Medicinal plants with the highest FL and ROP values and those used to treat disease categories with the highest ICF values should be prioritized in future phytochemical and pharmacological investigations.

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“… 57 Likewise, another study performed in Adama, Ethiopia, reported that the aerial part of R. multifidus displayed impressive activity against S. aureus and S. pyogenes . 58 …”

Section: Discussionmentioning

confidence: 99%

“…57 Likewise, another study performed in Adama, Ethiopia, reported that the aerial part of R. multifidus displayed impressive activity against S. aureus and S. pyogenes. 58 Based upon the results of antibacterial activities, only two plants, such as C. asiatica and S. marianum, were selected for further advanced assays, such as the mechanism of antibiosis and cytotoxicity. Our findings revealed some differences in the MIC and MBC values corresponding to the ATCC and MDR isolates of bacteria tested.…”

Section: Dovepressmentioning

confidence: 99%

Antibacterial Activity Against Multidrug-Resistant Clinical Isolates of Nine Plants from Chencha, Southern Ethiopia

Manilal¹,

Sabu²,

Abebe³

et al. 2023

IDR

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Background:The diminishing efficacy of antibiotics currently in use and the emergence of multidrug-resistant bacteria pose a grave threat to public health worldwide. Hence, new classes of antimicrobials are urgently required, and the search is continuing. Methods: Nine plants were chosen for the current work, which are collected from the highlands of Chencha, Ethiopia. Plant extracts containing secondary metabolites in various organic solvents were checked for antibacterial activity against type culture bacterial pathogens and MDR clinical isolates. The broth dilution technique was used to evaluate the minimum inhibitory and minimum bactericidal concentrations of highly active plant extracts, and time-kill kinetic and cytotoxic assays were performed using the most active plant extract. Results: Two plants (C. asiatica and S. marianum) were highly active against ATCC isolates. The EtOAc extract of C. asiatica produced the highest zone of inhibition ranging between 18.2±0.8-20.7±0.7 and 16.1±0.4-19.2±1.4 mm against Gram-positive and Gram-negative bacteria, respectively. The EtOH extract of S. marianum displayed zones of inhibition in the range of 19.9±1.4-20.5 ±0.7 mm against the type culture bacteria. The EtOAc extract of C. asiatica effectively curbed the growth of six MDR clinical isolates. The MIC values of C. asiatica against the Gram-negative bacteria tested were 2.5 mg/mL, whereas the corresponding MBC values were 5 mg/mL in each case. The MIC and MBC values were the lowest in the case of Gram-positive bacteria, ie, 0.65 and 1.25 mg/ mL, respectively. A time-kill assay showed the inhibition of MRSA at 4 × MIC and 8 × MIC within 2 hours of incubation. The 24 h LD 50 values of C. asiatica and S. marianum corresponding to Artemia salina were 3.05 and 2.75 mg/mL, respectively. Conclusion: Overall results substantiate the inclusion of C. asiatica and S. marianum as antibacterial agents in traditional medicines.

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Chemical composition and antibacterial activity of essential oils from various parts of Gladiolus candidus, Ranunculus multifidus, Artemisia abyssinica and Crinum abyscinicum

Cited by 6 publications

References 22 publications

Copaifera mildbraedii Desf.: Phytochemical Composition of Extracts, Essential Oil, and In Vitro Biological Activities of Bark

Copaifera mildbraedii Desf.: Phytochemical Composition of Extracts, Essential Oil, and In Vitro Biological Activities of Bark

Medicinal Plants Used by Oromo Community in Kofale District, West-Arsi Zone, Oromia Regional State, Ethiopia

Antibacterial Activity Against Multidrug-Resistant Clinical Isolates of Nine Plants from Chencha, Southern Ethiopia

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