Chemical Composition and Antibacterial and Cytotoxic Activities ofAllium hirtifoliumBoiss

Abstract

Allium hirtifolium Boiss. known as Persian shallot, is a spice used as a traditional medicine in Iran and, Mediterranean region. In this study, the chemical composition of the hydromethanolic extract of this plant was analyzed using GC/MS. The result showed that 9-hexadecenoic acid, 11,14-eicosadienoic acid, and n-hexadecanoic acid are the main constituents. The antibacterial activity of the shallot extract was also examined by disk diffusion and microdilution broth assays. It was demonstrated that Persian shallot hydromethanolic extract was effective against 10 different species of pathogenic bacteria including methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Escherichia coli, Escherichia coli O157:H7, Salmonella typhimurium, Proteus mirabilis, and Klebsiella pneumoniae. Specifically, the minimum concentration of the extract which inhibited bacterial growth (MIC values) was 1.88 mg/mL for most of the gram-positive bacteria. This concentration was not much different from the concentration that was safe for mammalian cells (1.50 mg/mL) suggesting that the hydromethanolic extract of Persian shallot may be a safe and strong antibacterial agent.

Characterization of Active Compounds of Different Garlic (Allium sativum L.) Cultivars

“…Moreover, an earlier study showed that garlic and onion, which both belong to the Allium hirtifolium genus, exhibited signifi cant cytoprotective effects on normal cells [Shrivastava & Ganesh, 2010]. Ismail et al [2013] demonstrated that 1.50 mg/mL extract from Allium hirtifolium was safe for mammalian cells. Our results showed that some of the studied garlic extracts did not suppress normal cell proliferation.…”

Antibiofilm, Antioxidant, Antimutagenic Activities and Phenolic Compounds of Allium orientale BOISS.

“…The relatively higher antimicrobial activity of the aerial parts extract could be indicative for the presence of some phenolic compounds such as (+)-catechin, apigenin and caffeic acid. Although antimicrobial activities of some Allium species have already been reported (Hannan et al 2010;Najjaa et al 2011;Ismail et al 2013;Bakht et al 2014), little attention was paid to their antibiofilm potential (Nidadavolu et al 2012;Ceylan 2014). In the antibiofilm quantification assay, a concentration dependent decrease in biofilm formation was observed in the test microorganisms when treated with the ethanol extracts of A. orientale.…”

The anti-dermatophyte activity of Allium hirtifolium Boiss aqueous extract

“…Many investigations have been performed on antimicrobial activities of Allium species, for example, the antimicrobial activity of A. ascalonicum [2,25] and A. hirtifolium [9,13,19,27]. However, there is no information about the anti-dermatophyte activity of A. hirtifolium aqueous extract.…”

“…Many authors have examined the antimicrobial [9,13,19,27], antioxidant [28], anti-parasitic activities [31,32] and immunomodulatory effects [10,14] of A. hirtifolium extracts or essential oil.…”